Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats

2012 ◽  
Vol 29 (5) ◽  
pp. 534-544 ◽  
Author(s):  
Nelli Giribabu ◽  
Sri Bhashyam Sainath ◽  
Pamanji Sreenivasula Reddy
Keyword(s):  
Male Rats ◽  
Phthalate Exposure ◽  
Butyl Phthalate

scholarly journals Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Wan-Ru Wang ◽  
Nai-Tzu Chen ◽  
Nai-Yun Hsu ◽  
I-Ying Kuo ◽  
Hsin-Wen Chang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Methylation Level ◽  
Respiratory Symptoms ◽  
Smoking Status ◽  
Phthalate Esters ◽  
Allergic Diseases ◽  
Percentage Increase ◽  
Phthalate Exposure ◽  
Settled Dust ◽  
Butyl Phthalate

Abstract Background Dysregulation of thymic stromal lymphopoietin (TSLP) expressions is linked to asthma and allergic disease. Exposure to phthalate esters, a widely used plasticizer, is associated with respiratory and allergic morbidity. Dibutyl phthalate (DBP) causes TSLP upregulation in the skin. In addition, phthalate exposure is associated with changes in environmentally induced DNA methylation, which might cause phenotypic heterogeneity. This study examined the DNA methylation of the TSLP gene to determine the potential mechanism between phthalate exposure and allergic diseases. Results Among all evaluated, only benzyl butyl phthalate (BBzP) in the settled dusts were negatively correlated with the methylation levels of TSLP and positively associated with children’s respiratory symptoms. The results revealed that every unit increase in BBzP concentration in the settled dust was associated with a 1.75% decrease in the methylation level on upstream 775 bp from the transcription start site (TSS) of TSLP (β =  − 1.75, p = 0.015) after adjustment for child’s sex, age, BMI, parents’ smoking status, allergic history, and education levels, PM2.5, formaldehyde, temperature; and relative humidity. Moreover, every percentage increase in the methylation level was associated with a 20% decrease in the risk of morning respiratory symptoms in the children (OR 0.80, 95% CI 0.65–0.99). Conclusions Exposure to BBzP in settled dust might increase children’s respiratory symptoms in the morning through decreasing TSLP methylation. Therefore, the exposure to BBzP should be reduced especially for the children already having allergic diseases.

scholarly journals Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults

Toxics ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 33
Author(s):  
Po-Ching Chu ◽  
Charlene Wu ◽  
Ta-Chen Su
Keyword(s):  
Young Adults ◽  
Endothelial Dysfunction ◽  
Vascular Diseases ◽  
Adolescents And Young Adults ◽  
Cardiovascular Risks ◽  
Phthalate Exposure ◽  
Butyl Phthalate ◽  
Microparticle Formation

Endothelial function is crucial in the pathogenesis of circulatory and cardiovascular toxicity; epidemiologic research investigating the association between phthalate exposure and endothelial dysfunction remains limited. We examined the associations between exposures to specific phthalates (di-2-ethylhexyl phthalate, DEHP; di-n-butyl phthalate, DnBP) and circulating endothelial and platelet microparticles (EMPs and PMPs) in adolescents and young adults. Of the 697 participants recruited, anthropometric measurements and health-related behaviors relevant to cardiovascular risks were collected and assessed. Urine and serum were collected and analyzed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and flow cytometry. Multiple linear regression indicated that increases in urinary concentrations of ΣDEHP and MnBP (mono-n-butyl phthalate), across quartiles, were positively associated with serum EMPs level (p for trend <0.001 and <0.001; β = 0.798 and 0.007; standard error = 0.189 and 0.001, respectively). Moreover, female and overweight subjects had higher MnBP, and males were more vulnerable to DnBP exposure compared to females. In conclusion, our results demonstrate a dose-response relationship between exposures to phthalates (ΣDEHP and MnBP) and microparticle formation (EMPs and PMPs) in adolescents and young adults. The findings indicate that exposures to phthalates of both low and high-molecular weight are positively associated with microparticle production, and might contribute to endothelial dysfunction; such damage might manifest in the form of atherosclerotic-related vascular diseases. Future in vivo and in vitro studies are warranted to elucidate whether a causal relationship exists between phthalate exposure and EMPs and PMPs.

Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate

2014 ◽  
Vol 31 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Zhi-Hong Liu ◽  
En-Hui Li ◽  
Dong-Liang Xu ◽  
Wen-Lan Sun ◽  
Yan Hong ◽  
...  
Keyword(s):  
Genetic Research ◽  
Anorectal Malformations ◽  
Male Rats ◽  
Butyl Phthalate

Protective effects of Lactobacillus plantarum strain P1 against toxicity of the environmental oestrogen di-n-butyl phthalate in rats

2020 ◽  
Vol 11 (8) ◽  
pp. 803-813
Author(s):  
X. Shi ◽  
C. Hu ◽  
S. Cai ◽  
X. Tao ◽  
Y. Zhou ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactobacillus Plantarum ◽  
Therapeutic Strategy ◽  
Male Rats ◽  
Protective Effects ◽  
Oral Gavage ◽  
Butyl Phthalate ◽  
Maize Oil

Phthalates are contaminants widely distributed in the food-chain, and they are considered as important environmental oestrogens in our lives. In the present study, eight strains of lactic acid bacteria were isolated for their ability to adsorb di-n-butyl-phthalate (DBP), and one of the strains, Lactobacillus plantarum strain P1, was selected for more detailed analyses of its phthalate adsorption capacity in vitro. This study also evaluated the in vivo protective effects of strain P1 against DBP toxicity in rats. Sixteen rats were divided into four groups, and animals received by oral gavage every other day for a period of one month saline with or without strain P1 at 2×1011 cfu/kg followed by maize oil with or without DBP (50 mg/kg). Strain P1 could adsorb more DBP than saline alone, and the concentration of mono-n-butyl phthalate in urine was decreased in animals receiving P1. Furthermore, oestrogenic effects of the different treatments were assessed through counting of sperm and observation of testis, and strain P1 could protect the sexual organs of male rats. Our results suggested that P1 is effective against phthalate toxicity due to its ability to adsorb DBP in vivo and could be considered as a new dietary therapeutic strategy against environmental phtalate toxicity.

scholarly journals Comparative Effects of Di( n -Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts

2015 ◽  
Vol 123 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Sander van den Driesche ◽  
Chris McKinnell ◽  
Ana Calarrão ◽  
Laura Kennedy ◽  
Gary R. Hutchison ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Development ◽  
Germ Cell Development ◽  
Fetal Testis ◽  
Phthalate Exposure ◽  
Butyl Phthalate ◽  
Fetal Germ Cell

scholarly journals Duration-dependent effects of high dose of phthalate exposure on semen quality in adult male rats

2021 ◽  
Author(s):  
Victor Emojevwe ◽  
Alexander O Naiho ◽  
Eze K Nwangwa ◽  
Mega O Oyovwi ◽  
Kenneth K Anachuna ◽  
...  
Keyword(s):  
Adult Male ◽  
Semen Quality ◽  
Male Rats ◽  
High Dose ◽  
Phthalate Exposure

scholarly journals The effects of di-butyl phthalate exposure from medications on human sperm RNA among men

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Molly Estill ◽  
Russ Hauser ◽  
Feiby L. Nassan ◽  
Alan Moss ◽  
Stephen A. Krawetz
Keyword(s):  
Human Sperm ◽  
Phthalate Exposure ◽  
Butyl Phthalate
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