scholarly journals Expression of the Shh/Bmp4 signaling pathway during the development of anorectal malformations in a male rat model of prenatal exposure to di(n-butyl) phthalate

2015 ◽  
Vol 4 (2) ◽  
pp. 241-247 ◽  
Author(s):  
En-Hui Li ◽  
Sheng-Jie Liang ◽  
Wen-Lan Sun ◽  
Dong-Liang Xu ◽  
Yan Hong ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Prenatal Exposure ◽  
Rat Model ◽  
Anorectal Malformations ◽  
Male Rat ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein ◽  
Butyl Phthalate

Sonic hedgehog (Shh)/bone morphogenetic protein 4 (Bmp4) is an androgen-regulated signaling pathway that has been shown to be crucial for embryonic development.

The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate

Toxicology ◽  
2012 ◽  
Vol 293 (1-3) ◽  
pp. 53-58 ◽  
Author(s):  
Shi-Bo Liu ◽  
Zheng Ma ◽  
Wen-Lan Sun ◽  
Xiao-Wen Sun ◽  
Yan Hong ◽  
...  
Keyword(s):  
Growth Factor ◽  
Prenatal Exposure ◽  
Rat Model ◽  
Male Rat ◽  
Butyl Phthalate ◽  
Genital Tubercle

Expression of Wnt5a during development of anorectal malformations in a rat model of prenatal exposure to di(n-butyl) phthalate

2014 ◽  
Vol 24 (7) ◽  
pp. 455-460 ◽  
Author(s):  
En-Hui Li ◽  
Bang-Min Han ◽  
Wen-Lan Sun ◽  
Sheng-Jie Liang ◽  
Shu-Jie Xia ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Rat Model ◽  
Anorectal Malformations ◽  
Butyl Phthalate

Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring

Toxicology ◽  
2011 ◽  
Vol 290 (2-3) ◽  
pp. 322-326 ◽  
Author(s):  
Jun-Tao Jiang ◽  
Wen-Lan Sun ◽  
Yi-Feng Jing ◽  
Shi-Bo Liu ◽  
Zheng Ma ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Anorectal Malformations ◽  
Male Rat ◽  
Rat Offspring ◽  
Butyl Phthalate

scholarly journals Baicalin improves the in vitro developmental capacity of pig embryos by inhibiting apoptosis, regulating mitochondrial activity and activating sonic hedgehog signaling

2019 ◽  
Vol 25 (9) ◽  
pp. 538-549 ◽  
Author(s):  
Qing Guo ◽  
Mei-Fu Xuan ◽  
Zhao-Bo Luo ◽  
Jun-Xia Wang ◽  
Sheng-Zhong Han ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Control Group ◽  
Mitochondrial Activity ◽  
Cell Stage ◽  
Shh Signaling ◽  
Developmental Capacity

Abstract Baicalin, a traditional Chinese medicinal monomer whose chemical structure is known, can be used to treat female infertility. However, the effect of baicalin on embryonic development is unknown. This study investigated the effects of baicalin on in vitro development of parthenogenetically activated (PA) and in vitro fertilized (IVF) pig embryos and the underlying mechanisms involved. Treatment with 0.1 μg/ml baicalin significantly improved (P < 0.05) the in vitro developmental capacity of PA pig embryos by reducing the reactive oxygen species (ROS) levels and apoptosis and increasing the mitochondrial membrane potential (ΔΨm) and ATP level. mRNA and protein expression of sonic hedgehog (SHH) and GLI1, which are related to the SHH signaling pathway, in PA pig embryos at the 2-cell stage, were significantly higher in the baicalin-treated group than in the control group. To confirm that the SHH signaling pathway is involved in the mechanism by which baicalin improves embryonic development, we treated embryos with baicalin in the absence or presence of cyclopamine (Cy), an inhibitor of this pathway. Cy abolished the effects of baicalin on in vitro embryonic development. In conclusion, baicalin improves the in vitro developmental capacity of PA and IVF pig embryos by inhibiting ROS production and apoptosis, regulating mitochondrial activity and activating SHH signaling.

scholarly journals Inhibition of MicroRNA-302 (miR-302) by Bone Morphogenetic Protein 4 (BMP4) Facilitates the BMP Signaling Pathway

2012 ◽  
Vol 287 (46) ◽  
pp. 38656-38664 ◽  
Author(s):  
Hara Kang ◽  
Justin Louie ◽  
Alexandra Weisman ◽  
Jessica Sheu-Gruttadauria ◽  
Brandi N. Davis-Dusenbery ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Signaling Pathway ◽  
Bmp Signaling ◽  
Bone Morphogenetic Protein 4 ◽  
Morphogenetic Protein
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