Teratogenic effects of direct injection of aqueous and protein-bound trypan blue into the bloodstream of 3-day chick embryos

Teratology ◽  
1970 ◽  
Vol 3 (3) ◽  
pp. 269-272 ◽  
Author(s):  
Stanley Kaplan ◽  
E. Marshall Johnson
Keyword(s):  
Trypan Blue ◽  
Direct Injection ◽  
Chick Embryos ◽  
Teratogenic Effects

Teratogenic Effects of Herpes Simplex, Vaccinia, Influenza - A (NWS), and Distemper Virus Infections on Early Chick Embryos.

1956 ◽  
Vol 92 (4) ◽  
pp. 675-682 ◽  
Author(s):  
H. D. Heath ◽  
H. H. Shear ◽  
D. T. Imagawa ◽  
M. H. Jones ◽  
J. M. Adams
Keyword(s):  
Herpes Simplex ◽  
Influenza A ◽  
Chick Embryos ◽  
Virus Infections ◽  
Teratogenic Effects

Early changes in limb buds of chick embryos after thalidomide treatment

Development ◽  
1966 ◽  
Vol 16 (2) ◽  
pp. 289-300
Author(s):  
A. Jurand
Keyword(s):  
Embryonic Development ◽  
Experimental Investigations ◽  
Experimental Production ◽  
Chick Embryos ◽  
Teratogenic Effects ◽  
Limb Buds ◽  
Experimental Animals ◽  
Almost All ◽  
Thalidomide Treatment

Since the first observations of hypoplastic and aplastic thalidomide deformities in infants (McBride, 1961; Lenz, 1962), the literature on this subject has grown to many hundreds of communications. Experimental investigations in almost all cases have been undertaken to show whether thalidomide and its metabolites have any teratogenic effects in experimental animals. Numerous review papers are available on this subject, e.g. Giroud, Tuchmann-Duplessis & Mercier-Parot (1962), Somers (1963), and Salzgeber & Wolff (1964). Chick embryos did not seem for some time to be suitable for experimental production of typical thalidomide deformities. However, Kemper (1962a, b), Yang, Yang & Liang (1962). Boylen, Home & Johnson (1963) and Leone (1963) have shown that thalidomide can produce a whole range of ectromelian deformities provided that it is introduced into the egg at a particular period of embryonic development.

Analysis of trypan blue-induced rumplessness in chick embryos

1967 ◽  
Vol 165 (3) ◽  
pp. 325-335 ◽  
Author(s):  
Stanley Kaplan ◽  
Casimer T. Grabowski
Keyword(s):  
Trypan Blue ◽  
Chick Embryos

Teratogenic Effects of Trypan Blue on Amphibian Embryos

Development ◽  
1956 ◽  
Vol 4 (2) ◽  
pp. 110-118
Author(s):  
C. H. Waddington ◽  
M. M. Perry
Keyword(s):  
Trypan Blue ◽  
Teratogenic Effects ◽  
Pregnant Rat ◽  
Vital Dye ◽  
Amphibian Embryos ◽  
Mammalian Embryos

Considerable interest has been aroused by the report of Gillman, Gilbert, Gillman, & Spence (1948) that the vital dye trypan blue when injected into the pregnant rat brings about the appearance of various abnormalities in the offspring. The mammal embryo is notoriously difficult to attack experimentally, and trypan blue therefore seems to provide a valuable tool which, moreover, might throw light on the mechanisms of the important effects which are known in some cases to be produced on the foetus by pathological states in the mother. Further studies on the effects of injected trypan blue on mammalian embryos have therefore been made by Hamburgh (1952, 1954), Waddington & Carter (1952, 1953), and Murakami and his collaborators (1952, 1954), all of whom worked on the mouse, and by Harm (1954) who studied the rabbit. All these authors agree, on the whole, in the type of results which they have obtained, although there are some minor differences between their reports which will be considered later.

Oxygen consumption in normal and trypan blue-treated chick embryos

Teratology ◽  
1968 ◽  
Vol 1 (4) ◽  
pp. 369-373 ◽  
Author(s):  
Stanley Kaplan ◽  
E. Marshall Johnson
Keyword(s):  
Oxygen Consumption ◽  
Trypan Blue ◽  
Chick Embryos

The teratogenic effects of 6-mercaptopurine on chick embryos in ovo

Teratology ◽  
1975 ◽  
Vol 11 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Randall B. Grubb ◽  
Ethel C. Montiegel
Keyword(s):  
Chick Embryos ◽  
In Ovo ◽  
Teratogenic Effects

The teratogenic effects of sugars on the chick embryo

Development ◽  
1974 ◽  
Vol 32 (3) ◽  
pp. 661-674
Author(s):  
A. F. Hughes ◽  
R. B. Freeman ◽  
T. Fadem
Keyword(s):  
Chick Embryo ◽  
Chick Embryos ◽  
Teratogenic Effects ◽  
Other Substances ◽  
Insoluble Form ◽  
Effect Of Treatment

The effect of treatment of chick embryos during the first day of incubation with a number of sugars is described. To some embryos solid sugars were applied in opened eggs; forothers the substances were injected in solution. By both methods, all sugars tested were found to be teratogenic, but no apparent general differences between mono-, di-, and trisaccharides were found. Nor were there any correlations between those which can be metabolised at these stages and their teratogenicity. The range of defects produced is similar to those found when embryos of this age are treated with other substances. In embryos treated with [14C] sucrose, some of the label is retained within the tissues in a bound, insoluble form. Possible implications of this finding are suggested.

Embryotoxic and Teratogenic Effects of Flocoumafen in Chick Embryos and White Rats

1992 ◽  
Vol 2 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Bouthaina A. A. Khalifa ◽  
Fatma M. S. Salem ◽  
M. A. Menha
Keyword(s):  
Chick Embryos ◽  
Teratogenic Effects ◽  
White Rats

scholarly journals Ex Ovo Model for Directly Visualizing Chick Embryo Development

2012 ◽  
Vol 74 (9) ◽  
pp. 628-634 ◽  
Author(s):  
Michael I. Dorrell ◽  
Michael Marcacci ◽  
Stephen Bravo ◽  
Troy Kurz ◽  
Jacob Tremblay ◽  
...  
Keyword(s):  
High School ◽  
Developmental Biology ◽  
Chick Embryo ◽  
Embryonic Development ◽  
Embryo Development ◽  
Grade Level ◽  
Chick Embryos ◽  
Teratogenic Effects ◽  
Junior High Students ◽  
Chick Development

We describe a technique for removing and growing chick embryos in culture that utilizes relatively inexpensive materials and requires little space. It can be readily performed in class by university, high school, or junior high students, and teachers of any grade level should be able to set it up for their students. Students will be able to directly observe the chick’s development from 3 days post-fertilization to the point at which it would normally hatch. Observing embryonic development first hand, including the chick embryos’ natural movements, gives students a full appreciation for the complexity and wonder of development. Students can make detailed observations and drawings, and gain understanding of important principles in developmental biology. Finally, we suggest various ways in which this project can be adapted to allow students in advanced classes to design and implement their own projects for investigating teratogenic effects on development using the ex ovo model of chick development.

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