scholarly journals Dura Mater Stimulates Human Adipose-Derived Stromal Cells to Undergo Bone Formation in Mouse Calvarial Defects

Stem Cells ◽  
2011 ◽  
Vol 29 (8) ◽  
pp. 1241-1255 ◽  
Author(s):  
Benjamin Levi ◽  
Emily R. Nelson ◽  
Shuli Li ◽  
Aaron W. James ◽  
Jeong S. Hyun ◽  
...  
Keyword(s):  
Bone Formation ◽  
Dura Mater ◽  
Stromal Cells ◽  
Adipose Derived Stromal Cells ◽  
Calvarial Defects

In Vivo Bone Formation Following Transplantation of Human Adipose–Derived Stromal Cells That Are Not Differentiated Osteogenically

2008 ◽  
Vol 14 (8) ◽  
pp. 1285-1294 ◽  
Author(s):  
Oju Jeon ◽  
Jong Won Rhie ◽  
Il-Kuen Kwon ◽  
Jae-Hwan Kim ◽  
Byung-Soo Kim ◽  
...  
Keyword(s):  
Bone Formation ◽  
Stromal Cells ◽  
Adipose Derived Stromal Cells ◽  
In Vivo Bone Formation

Adipose-Derived Stromal Cells (ADSCs) Promote Bone Formation In Vivo Not by Transforming to Osteoblasts

2018 ◽  
Vol 8 (5) ◽  
pp. 624-631
Author(s):  
Xiaoyu Li ◽  
Jinfeng Yao ◽  
Xinya Du ◽  
Wei Jing ◽  
Weidong Tian
Keyword(s):  
Bone Formation ◽  
Stromal Cells ◽  
Adipose Derived Stromal Cells

scholarly journals Extracellular matrix and α5β1 integrin signaling control the maintenance of bone formation capacity by human adipose-derived stromal cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nunzia Di Maggio ◽  
Elisa Martella ◽  
Agne Frismantiene ◽  
Therese J. Resink ◽  
Simone Schreiner ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Bone Formation ◽  
Stromal Cells ◽  
Integrin Signaling ◽  
Adipose Derived Stromal Cells ◽  
Α5β1 Integrin

scholarly journals Human Adipose Derived Stromal Cells Heal Critical Size Mouse Calvarial Defects

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e11177 ◽  
Author(s):  
Benjamin Levi ◽  
Aaron W. James ◽  
Emily R. Nelson ◽  
Dean Vistnes ◽  
Benjamin Wu ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Critical Size ◽  
Adipose Derived Stromal Cells ◽  
Calvarial Defects

Osteogenic Induction of Adipose-derived Stromal Cells: Not a Requirement for Bone Formation In Vivo

2010 ◽  
Vol 34 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Xiaoyu Li ◽  
Jinfeng Yao ◽  
Ling Wu ◽  
Wei Jing ◽  
Wei Tang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Stromal Cells ◽  
Adipose Derived Stromal Cells ◽  
Osteogenic Induction

In Vitro Calcium Pretreatment Enhances Bone Formation of Human Adipose Derived Stromal Cells In Vivo

2016 ◽  
Vol 6 (1) ◽  
pp. 20-26
Author(s):  
Shaowen Cheng ◽  
Jingkai Zhao ◽  
Xu Zhang ◽  
Hua Zhang ◽  
Lei Peng ◽  
...  
Keyword(s):  
Bone Formation ◽  
Stromal Cells ◽  
Adipose Derived Stromal Cells

scholarly journals Cell Therapy: Effect of Locally Injected Mesenchymal Stromal Cells Derived from Bone Marrow or Adipose Tissue on Bone Regeneration of Rat Calvarial Defects

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Gileade P. Freitas ◽  
Helena B. Lopes ◽  
Alann T. P. Souza ◽  
Paula G. F. P. Oliveira ◽  
Adriana L. G. Almeida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Cell Therapy ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Local Injection ◽  
Expression Of Genes ◽  
Calvarial Defects

Abstract Treatment of large bone defects is a challenging clinical situation that may be benefited from cell therapies based on regenerative medicine. This study was conducted to evaluate the effect of local injection of bone marrow-derived mesenchymal stromal cells (BM-MSCs) or adipose tissue-derived MSCs (AT-MSCs) on the regeneration of rat calvarial defects. BM-MSCs and AT-MSCs were characterized based on their expression of specific surface markers; cell viability was evaluated after injection with a 21-G needle. Defects measuring 5 mm that were created in rat calvaria were injected with BM-MSCs, AT-MSCs, or vehicle-phosphate-buffered saline (Control) 2 weeks post-defect creation. Cells were tracked by bioluminescence, and 4 weeks post-injection, the newly formed bone was evaluated by µCT, histology, nanoindentation, and gene expression of bone markers. BM-MSCs and AT-MSCs exhibited the characteristics of MSCs and maintained their viability after passing through the 21-G needle. Injection of both BM-MSCs and AT-MSCs resulted in increased bone formation compared to that in Control and with similar mechanical properties as those of native bone. The expression of genes associated with bone formation was higher in the newly formed bone induced by BM-MSCs, whereas the expression of genes involved in bone resorption was higher in the AT-MSC group. Cell therapy based on local injection of BM-MSCs or AT-MSCs is effective in delivering cells that induced a significant improvement in bone healing. Despite differences observed in molecular cues between BM-MSCs and AT-MSCs, both cells had the ability to induce bone tissue formation at comparable amounts and properties. These results may drive new cell therapy approaches toward complete bone regeneration.

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