scholarly journals The Impact of Protein Corona Formation on the Macrophage Cellular Uptake and Biodistribution of Spherical Nucleic Acids

Small ◽  
2017 ◽  
Vol 13 (16) ◽  
pp. 1603847 ◽  
Author(s):  
Alyssa B. Chinen ◽  
Chenxia M. Guan ◽  
Caroline H. Ko ◽  
Chad A. Mirkin
Keyword(s):  
Nucleic Acids ◽  
Cellular Uptake ◽  
Protein Corona ◽  
Corona Formation ◽  
Spherical Nucleic Acids ◽  
The Impact

Protein corona formation and its influence on biomimetic magnetite nanoparticles

2020 ◽  
Vol 8 (22) ◽  
pp. 4870-4882 ◽  
Author(s):  
Ana Peigneux ◽  
Emanuel A. Glitscher ◽  
Rawan Charbaji ◽  
Christoph Weise ◽  
Stefanie Wedepohl ◽  
...  
Keyword(s):  
Human Plasma ◽  
Cellular Uptake ◽  
Magnetite Nanoparticles ◽  
Colloidal Stability ◽  
Protein Corona ◽  
Corona Formation

Colloidal stability and cellular uptake of MamC-biomimetic magnetite nanoparticles (BMNPs) incubated with human plasma (PC-BMNPs).

Surface roughness influences the protein corona formation of glycosylated nanoparticles and alter their cellular uptake

Nanoscale ◽  
2019 ◽  
Vol 11 (48) ◽  
pp. 23259-23267 ◽  
Author(s):  
Alberto Piloni ◽  
Chin Ken Wong ◽  
Fan Chen ◽  
Megan Lord ◽  
Andreas Walther ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Cellular Uptake ◽  
Protein Corona ◽  
Biological Behavior ◽  
Protein Absorption ◽  
Corona Formation

Patterned nanoparticle surfaces can repel protein absorption and prevent the formation of a protein corona, which alters the biological behavior and therefore the fate of the nanoparticle.

scholarly journals Surface Charge-Dependent Cellular Uptake of Polystyrene Nanoparticles

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 1028 ◽  
Author(s):  
Soyeon Jeon ◽  
Jessica Clavadetscher ◽  
Dong-Keun Lee ◽  
Sunay Chankeshwara ◽  
Mark Bradley ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Surface Charge ◽  
Cellular Uptake ◽  
A549 Cells ◽  
Protein Corona ◽  
Polystyrene Nanoparticles ◽  
Biological Impact ◽  
Corona Formation ◽  
Different Types

The evaluation of the role of physicochemical properties in the toxicity of nanoparticles is important for the understanding of toxicity mechanisms and for controlling the behavior of nanoparticles. The surface charge of nanoparticles is suggested as one of the key parameters which decide their biological impact. In this study, we synthesized fluorophore-conjugated polystyrene nanoparticles (F-PLNPs), with seven different types of surface functional groups that were all based on an identical core, to evaluate the role of surface charge in the cellular uptake of nanoparticles. Phagocytic differentiated THP-1 cells or non-phagocytic A549 cells were incubated with F-PLNP for 4 h, and their cellular uptake was quantified by fluorescence intensity and confocal microscopy. The amount of internalized F-PLNPs showed a good positive correlation with the zeta potential of F-PLNPs in both cell lines (Pearson’s r = 0.7021 and 0.7852 for zeta potential vs. cellular uptake in THP-1 cells and nonphagocytic A549 cells, respectively). This result implies that surface charge is the major parameter determining cellular uptake efficiency, although other factors such as aggregation/agglomeration, protein corona formation, and compositional elements can also influence the cellular uptake partly or indirectly.

scholarly journals Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Marianna Barbalinardo ◽  
Jessika Bertacchini ◽  
Linda Bergamini ◽  
Maria Sara Magarò ◽  
Luca Ortolani ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Surface Properties ◽  
Cellular Uptake ◽  
Biomedical Applications ◽  
Protein Corona ◽  
Diagnosis And Treatment ◽  
Corona Formation ◽  
Basic Understanding

Nanoparticles (NPs) have been studied for biomedical applications, ranging from prevention, diagnosis and treatment of diseases. However, the lack of the basic understanding of how NPs interact with the biological...

scholarly journals Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization

2017 ◽  
Vol 18 (2) ◽  
pp. 483-489 ◽  
Author(s):  
Resham J. Banga ◽  
Sai Archana Krovi ◽  
Suguna P. Narayan ◽  
Anthony J. Sprangers ◽  
Guoliang Liu ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
Polymeric Nanoparticles ◽  
Spherical Nucleic Acids

Protein Corona Formation on Colloidal Polymeric Nanoparticles and Polymeric Nanogels: Impact on Cellular Uptake, Toxicity, Immunogenicity, and Drug Release Properties

2017 ◽  
Vol 18 (6) ◽  
pp. 1762-1771 ◽  
Author(s):  
Katja Obst ◽  
Guy Yealland ◽  
Benjamin Balzus ◽  
Enrico Miceli ◽  
Mathias Dimde ◽  
...  
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Polymeric Nanoparticles ◽  
Protein Corona ◽  
Corona Formation

Backbone-modified oligonucleotides for tuning the cellular uptake behaviour of spherical nucleic acids

2017 ◽  
Vol 5 (3) ◽  
pp. 412-416 ◽  
Author(s):  
Woo Chul Song ◽  
Kyoung-Ran Kim ◽  
Miri Park ◽  
Kyung Eun Lee ◽  
Dae-Ro Ahn
Keyword(s):  
Nucleic Acids ◽  
Cellular Uptake ◽  
Modified Oligonucleotides ◽  
Uptake Efficiency ◽  
Spherical Nucleic Acids ◽  
Cellular Uptake Efficiency

Spherical nucleic acids (SNAs) were prepared using sugar backbone-modified oligonucleotides, and the effects of the oligonucleotides on the cellular uptake efficiency of SNAs were investigated.

Insight into the interactions between nanoparticles and cells

2017 ◽  
Vol 5 (2) ◽  
pp. 173-189 ◽  
Author(s):  
Jingchao Li ◽  
Hongli Mao ◽  
Naoki Kawazoe ◽  
Guoping Chen
Keyword(s):  
Cell Proliferation ◽  
Surface Chemistry ◽  
Cellular Uptake ◽  
Shell Structure ◽  
Protein Corona ◽  
Cellular Responses ◽  
Cellular Mechanics ◽  
Corona Formation ◽  
Structure Surface ◽  
Insight Into

This review summarizes the latest advances in nanoparticle (NP)–cell interactions. The influence of NP size, shape, shell structure, surface chemistry and protein corona formation on cellular uptake and cytotoxicity is highlighted in detail. Their impact on other cellular responses such as cell proliferation, differentiation and cellular mechanics is also discussed.

scholarly journals Surface properties modulate protein corona formation and determine cellular uptake and cytotoxicity of silver nanoparticles

2021 ◽  
Author(s):  
Denis Gentili ◽  
Marianna Barbalinardo ◽  
Jessika Bertacchini ◽  
Linda Bergamini ◽  
Maria Sara Magarò ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Surface Properties ◽  
Cellular Uptake ◽  
Protein Corona ◽  
Corona Formation
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