scholarly journals Magnetic Suspension Array Technology: Controlled Synthesis and Screening in Microfluidic Networks

Small ◽  
2016 ◽  
Vol 12 (33) ◽  
pp. 4553-4562 ◽  
Author(s):  
Gungun Lin ◽  
Dmitriy D. Karnaushenko ◽  
Gilbert Santiago Cañón Bermúdez ◽  
Oliver G. Schmidt ◽  
Denys Makarov
Keyword(s):  
Magnetic Suspension ◽  
Controlled Synthesis ◽  
Suspension Array ◽  
Array Technology ◽  
Microfluidic Networks

scholarly journals Droplet Microfluidics: Magnetic Suspension Array Technology: Controlled Synthesis and Screening in Microfluidic Networks (Small 33/2016)

Small ◽  
2016 ◽  
Vol 12 (33) ◽  
pp. 4580-4580
Author(s):  
Gungun Lin ◽  
Dmitriy D. Karnaushenko ◽  
Gilbert Santiago Cañón Bermúdez ◽  
Oliver G. Schmidt ◽  
Denys Makarov
Keyword(s):  
Droplet Microfluidics ◽  
Magnetic Suspension ◽  
Controlled Synthesis ◽  
Suspension Array ◽  
Array Technology ◽  
Microfluidic Networks

Simultaneous detection of five antibiotics in milk by high-throughput suspension array technology

Talanta ◽  
2011 ◽  
Vol 85 (2) ◽  
pp. 1160-1165 ◽  
Author(s):  
Pu Su ◽  
Nan Liu ◽  
Maoxiang Zhu ◽  
Baoan Ning ◽  
Ming Liu ◽  
...  
Keyword(s):  
High Throughput ◽  
Simultaneous Detection ◽  
Suspension Array ◽  
Array Technology

Microsphere suspension array technology for SNP detection in cattle

2003 ◽  
Vol 22 (4) ◽  
pp. 158-162 ◽  
Author(s):  
S. Dunbar ◽  
R. Godbout ◽  
H. Newkirk ◽  
J. Hetzel
Keyword(s):  
Snp Detection ◽  
Suspension Array ◽  
Array Technology

scholarly journals Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Valérie Briand ◽  
Gilles Cottrell ◽  
Nicaise Tuike Ndam ◽  
Xavier Martiáñez-Vendrell ◽  
Bertin Vianou ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Diagnostic Test ◽  
Rapid Diagnostic Test ◽  
Parasite Density ◽  
Quantitative Polymerase Chain Reaction ◽  
Suspension Array ◽  
Increased Risk ◽  
Array Technology ◽  
Highly Sensitive ◽  
Polymerase Chain

Abstract Background While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for the detection of infections of low parasite density in pregnant women. Methods This was a retrospective study based on samples collected in Benin from 2014 to 2017. A total of 942 whole blood samples collected in 327 women in the 1st and 3rd trimesters and at delivery were tested by uRDT, conventional RDT (cRDT, SD BIOLINE Malaria Ag Pf), microscopy, quantitative polymerase chain-reaction (qPCR) and Luminex-based suspension array technology targeting P. falciparum HRP2. The performance of each RDT was evaluated using qPCR as reference standard. The association between infections detected by uRDT, but not by cRDT, with poor maternal and birth outcomes was assessed using multivariate regression models. Results The overall positivity rate detected by cRDT, uRDT, and qPCR was 11.6% (109/942), 16.2% (153/942) and 18.3% (172/942), respectively. Out of 172 qPCR-positive samples, 68 were uRDT-negative. uRDT had a significantly better sensitivity (60.5% [52.7–67.8]) than cRDT (44.2% [36.6–51.9]) and a marginally decreased specificity (93.6% [91.7–95.3] versus 95.7% [94.0–97.0]). The gain in sensitivity was particularly high (33%) and statistically significant in the 1st trimester. Only 28 (41%) out of the 68 samples which were qPCR-positive, but uRDT-negative had detectable but very low levels of HRP2 (191 ng/mL). Infections that were detected by uRDT but not by cRDT were associated with a 3.4-times (95%CI 1.29–9.19) increased risk of anaemia during pregnancy. Conclusions This study demonstrates the higher performance of uRDT, as compared to cRDTs, to detect low parasite density P. falciparum infections during pregnancy, particularly in the 1st trimester. uRDT allowed the detection of infections associated with maternal anaemia.

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