Multifunctional Magnetic Gd3+-Based Coordination Polymer Nanoparticles: Combination of Magnetic Resonance and Multispectral Optoacoustic Detections for Tumor-Targeted Imaging in vivo

Small ◽  
2015 ◽  
Vol 11 (42) ◽  
pp. 5675-5686 ◽  
Author(s):  
Qiao An ◽  
Jing Liu ◽  
Meng Yu ◽  
Jiaxun Wan ◽  
Dian Li ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Polymer Nanoparticles ◽  
Targeted Imaging

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

scholarly journals Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1258
Author(s):  
N. Arias-Ramos ◽  
L. E. Ibarra ◽  
M. Serrano-Torres ◽  
B. Yagüe ◽  
M. D. Caverzán ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Conjugated Polymer ◽  
Colloidal Stability ◽  
Fluorescent Imaging ◽  
Polymer Nanoparticles ◽  
Biodistribution Studies ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.

Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo

2014 ◽  
Vol 136 (6) ◽  
pp. 2413-2419 ◽  
Author(s):  
Barbara E. Rolfe ◽  
Idriss Blakey ◽  
Oliver Squires ◽  
Hui Peng ◽  
Nathan R. B. Boase ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Multimodal Imaging ◽  
Optical Detection ◽  
Polymer Nanoparticles

scholarly journals Accurate Monitoring of Renal Injury State through in Vivo Magnetic Resonance Imaging with Ferric Coordination Polymer Nanodots

ACS Omega ◽  
2018 ◽  
Vol 3 (5) ◽  
pp. 4918-4923 ◽  
Author(s):  
Xiaodong Li ◽  
Hongda Chen ◽  
Fuyao Liu ◽  
Yixin Chen ◽  
Huimao Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Renal Injury ◽  
Resonance Imaging

Fluorescence Turn-On Detection of Ascorbic Acid Using a Self-Assembled Lanthanide Polymer Nanoparticle

2019 ◽  
Vol 74 (3) ◽  
pp. 275-284
Author(s):  
Hui-Hui Zeng ◽  
Fang Liu ◽  
Long-Ke Hu ◽  
Jie Deng ◽  
Yue-Ping Xie ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Coordination Polymer ◽  
Fluorescence Probe ◽  
Signal To Noise Ratio ◽  
Polymer Nanoparticles ◽  
Sensing Systems ◽  
Sensing Platforms ◽  
Lanthanide Coordination Polymer ◽  
Fluorescence Turn On

Ascorbic acid (AA), or vitamin C, is an important reactive biological molecule in vivo, and an abnormal level of AA is associated with many diseases. Therefore, the rapid, sensitive, and selective detection of AA levels is of significance in cases of medical assay and diagnosis. Compared with other nanoparticles, lanthanide coordination polymer nanoparticles (Ln-CPs) have been demonstrated as the excellent biomolecule sensing platforms due to their unique optical properties and intrinsic porosities. In this work, the cerium coordination polymer nanoparticles ATP-Ce-Tris were synthesized in a simple and quick way. The synthesized ATP-Ce-Tris nanoparticle shows the characteristic peak of Ce3+ located at 365 nm, which is corresponding to the 4f→5d transition of Ce3+. In the presence of Fe3+, the fluorescence of ATP-Ce-Tris quenched, and the following added ascorbic acid (AA) makes it restoring effectively. Based on this, we constructed a fluorescence probe with excellent sensitivity for AA sensing in a wide linear relationship from 0.05 to 500 μM. The detection limit was as low as 18 nM (signal-to-noise ratio of three), which is one or two orders of magnitude lower than those of reported sensors. The proposed sensing systems also exhibits excellent sensitivity for AA detection in human serum sample, exploiting a valuable platform for AA analysis in clinic diagnostic and drug screening.

Synthesis of gadolinium/iron–bimetal–phenolic coordination polymer nanoparticles for theranostic applications

Nanoscale ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 6096-6103 ◽  
Author(s):  
Jing Qin ◽  
Guohai Liang ◽  
Youyou Feng ◽  
Bingxi Feng ◽  
Gen Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Photothermal Therapy ◽  
Polymer Nanoparticles ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging ◽  
Theranostic Applications

Gd/Fe–bimetal–phenolic coordination polymer nanoparticles are successfully synthesized and used for enhanced T1-weighted magnetic resonance imaging and photothermal therapy.

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