Synthesis of gadolinium/iron–bimetal–phenolic coordination polymer nanoparticles for theranostic applications

Nanoscale ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 6096-6103 ◽  
Author(s):  
Jing Qin ◽  
Guohai Liang ◽  
Youyou Feng ◽  
Bingxi Feng ◽  
Gen Wang ◽  
...  

Gd/Fe–bimetal–phenolic coordination polymer nanoparticles are successfully synthesized and used for enhanced T1-weighted magnetic resonance imaging and photothermal therapy.

2018 ◽  
Vol 6 (40) ◽  
pp. 6391-6398 ◽  
Author(s):  
Yiming Yu ◽  
Bin Chi ◽  
Leping Lin ◽  
Zhe Yang ◽  
Qianyuan He ◽  
...  

Magnetic resonance imaging (MRI)-guided photothermal therapy (PTT) has recently attracted tremendous attention.


2020 ◽  
Vol 8 (36) ◽  
pp. 8356-8367
Author(s):  
Gohar Ijaz Dar ◽  
M. Zubair Iqbal ◽  
Ozioma Udochukwu Akakuru ◽  
Chenyang Yao ◽  
Gul Awiaz ◽  
...  

The integration of advanced diagnostic contrast agents with versatile therapeutic nanoparticles presents an effective method for cancer treatment.


2017 ◽  
Vol 5 (43) ◽  
pp. 8554-8562 ◽  
Author(s):  
Jiaxin Liu ◽  
Hongda Chen ◽  
Yu Fu ◽  
Xiaodong Li ◽  
Yixin Chen ◽  
...  

Fe2O3@PDA-affibody integrates T2-weighted magnetic resonance imaging (MRI), tumor-targeting, and magnetic field (MF)-enhanced photothermal therapy (PTT) functionalities into an all-in-one system.


Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2107
Author(s):  
Jing Qu ◽  
Devin Guillory ◽  
Pohlee Cheah ◽  
Bin Tian ◽  
Jie Zheng ◽  
...  

The design and development of multifunctional nanoparticles have attracted great interest in biomedical research. This study aims to prepare pH-responsive melanin-like nanoparticles for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy. The new multifunctional nanoparticles (amino-Fe-PDANPs) are synthesized by copolymerization of dopamine and its derivative amino-N-[2-(diethylamino) ethyl]-3,4-dihydroxy-benzenepropanamide (N-Dopa) at room temperature. The size of nanoparticles can be controlled by NaOH concentration. The incorporation of N-Dopa is characterized by NMR and FT-IR. From transmission electron microscopy (TEM), the nanoparticles exhibit excellent dispersion stability in water and are spherical in shape. The MRI measurement has demonstrated that amino-Fe-PDANPs have a significant signal enhancement in responding to the acidic solution. Confirmed by the photothermal study, the nanoparticles exhibit a high photothermal conversion efficiency. The melanin-like multifunctional nanoparticles integrate both diagnosis and therapeutic functionalities, indicating the potential for theranostic application.


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