Hybridization of Bioelectrochemically Functional Infinite Coordination Polymer Nanoparticles with Carbon Nanotubes for Highly Sensitive and Selective In Vivo Electrochemical Monitoring

2013 ◽  
Vol 85 (8) ◽  
pp. 4007-4013 ◽  
Author(s):  
Xulin Lu ◽  
Hanjun Cheng ◽  
Pengcheng Huang ◽  
Lifen Yang ◽  
Ping Yu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Coordination Polymer ◽  
Polymer Nanoparticles ◽  
Highly Sensitive ◽  
Electrochemical Monitoring

scholarly journals Electrochemical Detection of Adrenaline and Hydrogen Peroxide on Carbon Nanotube Electrodes

2021 ◽  
Author(s):  
Gaurang Khot ◽  
Mohsin Kaboli ◽  
Tansu Celikel ◽  
Neil Shirtcliffe
Keyword(s):  
Carbon Nanotubes ◽  
Hydrogen Peroxide ◽  
Carbon Nanotube ◽  
Electrochemical Detection ◽  
Electrochemical Sensors ◽  
Carbon Electrodes ◽  
Cyclic Voltammetric ◽  
Highly Sensitive

Adrenaline and hydrogen peroxide have neuromodulatory functions in the brain.Considerable interest exists in developing electrochemical sensors that can detect their levels in vivo due to their important biochemical roles. Challenges associated with electrochemical detection of hydrogen peroxide and adrenaline are that the oxidation of these molecules usually requires highly oxidising potentials (beyond 1.4V vs Ag/AgCl) where electrode damage and biofouling are likely and the signals of adrenaline, hydrogen peroxide and adenosine overlap. To address these issues we fabricated pyrolysed carbon electrodes coated with oxidised carbon nanotubes (CNTs). Using these electrodes for fast-scan cyclic voltammetric (FSCV) measurements showed that the electrode offers reduced overpotentials compared with graphite and improved resistance to biofouling. The Adrenaline peak is reached at 0.75 V and reduced back at -0.2 V while hydrogen peroxide is detected at 0.85V on this electrode. The electrodes are highly sensitive with a sensitivity of16nA microM-1 for Adrenaline and 11nA microM-1 for hydrogen peroxide on an 80 micro m2 electrode. They are also suitable to distinguish between adrenaline, hydrogen peroxide and adenosine thus these probes can be used for multimodal detection of analytes.

Fluorescence Turn-On Detection of Ascorbic Acid Using a Self-Assembled Lanthanide Polymer Nanoparticle

2019 ◽  
Vol 74 (3) ◽  
pp. 275-284
Author(s):  
Hui-Hui Zeng ◽  
Fang Liu ◽  
Long-Ke Hu ◽  
Jie Deng ◽  
Yue-Ping Xie ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Coordination Polymer ◽  
Fluorescence Probe ◽  
Signal To Noise Ratio ◽  
Polymer Nanoparticles ◽  
Sensing Systems ◽  
Sensing Platforms ◽  
Lanthanide Coordination Polymer ◽  
Fluorescence Turn On

Ascorbic acid (AA), or vitamin C, is an important reactive biological molecule in vivo, and an abnormal level of AA is associated with many diseases. Therefore, the rapid, sensitive, and selective detection of AA levels is of significance in cases of medical assay and diagnosis. Compared with other nanoparticles, lanthanide coordination polymer nanoparticles (Ln-CPs) have been demonstrated as the excellent biomolecule sensing platforms due to their unique optical properties and intrinsic porosities. In this work, the cerium coordination polymer nanoparticles ATP-Ce-Tris were synthesized in a simple and quick way. The synthesized ATP-Ce-Tris nanoparticle shows the characteristic peak of Ce3+ located at 365 nm, which is corresponding to the 4f→5d transition of Ce3+. In the presence of Fe3+, the fluorescence of ATP-Ce-Tris quenched, and the following added ascorbic acid (AA) makes it restoring effectively. Based on this, we constructed a fluorescence probe with excellent sensitivity for AA sensing in a wide linear relationship from 0.05 to 500 μM. The detection limit was as low as 18 nM (signal-to-noise ratio of three), which is one or two orders of magnitude lower than those of reported sensors. The proposed sensing systems also exhibits excellent sensitivity for AA detection in human serum sample, exploiting a valuable platform for AA analysis in clinic diagnostic and drug screening.

Synthesis and 31 P NMR characterization of new low toxic highly sensitive pH probes designed for in vivo acidic pH studies

2002 ◽  
Vol 10 (5) ◽  
pp. 1451-1458 ◽  
Author(s):  
Sophie Martel ◽  
Jean-Louis Clément ◽  
Agnès Muller ◽  
Marcel Culcasi ◽  
Sylvia Pietri
Keyword(s):  
Acidic Ph ◽  
Highly Sensitive ◽  
Nmr Characterization ◽  
Low Toxic ◽  
Ph Probes

scholarly journals Occupational Exposure to Carbon Nanotubes and Carbon Nanofibres: More Than a Cobweb

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 745
Author(s):  
Enrico Bergamaschi ◽  
Giacomo Garzaro ◽  
Georgia Wilson Jones ◽  
Martina Buglisi ◽  
Michele Caniglia ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Animal Studies ◽  
Chemical Properties ◽  
Biological Behavior ◽  
Cross Sectional ◽  
Carbon Nanofibres ◽  
Material Entity ◽  
Cross Sectional Design

Carbon nanotubes (CNTs) and carbon nanofibers (CNFs) are erroneously considered as singular material entities. Instead, they should be regarded as a heterogeneous class of materials bearing different properties eliciting peculiar biological outcomes both in vitro and in vivo. Given the pace at which the industrial production of CNTs/CNFs is increasing, it is becoming of utmost importance to acquire comprehensive knowledge regarding their biological activity and their hazardous effects in humans. Animal studies carried out by inhalation showed that some CNTs/CNFs species can cause deleterious effects such as inflammation and lung tissue remodeling. Their physico-chemical properties, biological behavior and biopersistence make them similar to asbestos fibers. Human studies suggest some mild effects in workers handling CNT/CNF. However, owing to their cross-sectional design, researchers have been as yet unable to firmly demonstrate a causal relationship between such an exposure and the observed effects. Estimation of acceptable exposure levels should warrant a proper risk management. The aim of this review is to challenge the conception of CNTs/CNFs as a single, unified material entity and prompt the establishment of standardized hazard and exposure assessment methodologies able to properly feeding risk assessment and management frameworks.

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