scholarly journals Maternal iron status during early pregnancy and school‐age, lung function, asthma, and allergy: The Generation R Study

2021 ◽  
Author(s):  
Hugo G. Quezada‐Pinedo ◽  
Sara M. Mensink‐Bout ◽  
Irwin K. Reiss ◽  
Vincent W. V. Jaddoe ◽  
Marijn J. Vermeulen ◽  
...  
Keyword(s):  
Lung Function ◽  
Early Pregnancy ◽  
Iron Status ◽  
School Age ◽  
Asthma And Allergy ◽  
Maternal Iron

scholarly journals Preschool Asthma Symptoms in Children Born Preterm: The Relevance of Lung Function in Infancy

2020 ◽  
Vol 9 (10) ◽  
pp. 3345
Author(s):  
Manuel Sanchez-Solis ◽  
Maria Soledad Parra-Carrillo ◽  
Pedro Mondejar-Lopez ◽  
Patricia W Garcia-Marcos ◽  
Luis Garcia-Marcos
Keyword(s):  
Lung Function ◽  
Hospital Admissions ◽  
International Study ◽  
School Age ◽  
Lung Function Tests ◽  
The Core ◽  
The Past ◽  
Asthma Symptoms ◽  
Asthma And Allergy ◽  
Preterm Newborns

Background: The aim of the study is to assess whether lung function of infants born preterm predicts wheezing in pre-school age. Methods: A survey of the core wheezing questionnaire of the International Study on Asthma and Allergy in Children was administered to parents of preterm newborns, to whom lung function tests were performed at a corrected age of six months, and who, at the time of the survey, were between three and nine years of age. Results: Low values of all lung function parameters measured, except FVC, were predictors of wheezing at some time in life, (FEV0.5 OR: 0.62 (95%CI 0.39; 0.995); FEV0.5/FVC OR: 0.73 (0.54; 0.99)) FEF75 OR: 0.60 [0.37; 0.93]; FEF25-75 OR: 0.57 (0.37; 0.89)); and of wheezing in the past year (FEV0.5 OR: 0.36 (0.17; 0.76); FEV0.5/FVC OR: 0.59 (0.38; 0.93); FEF75 OR: 0.38 [0.19; 0.76]; FEF25-75 OR: 0.35 (0.17; 0.70). In addition, FEV0.5/FVC values lower than the lowest limit of normality, were predictive of hospital admissions due to wheezing (OR: 3.07; (1.02; 9.25)). Conclusions: Limited lung function in infancy is predictive of both future wheezing and hospitalization for a wheezing episode.

scholarly journals The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2418 ◽  
Author(s):  
Lucía Iglesias Vázquez ◽  
Victoria Arija ◽  
Núria Aranda ◽  
Estefanía Aparicio ◽  
Núria Serrat ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Early Pregnancy ◽  
Iron Supplementation ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Hfe Gene ◽  
Excess Iron ◽  
Spanish Women ◽  
Maternal Iron ◽  
Different Doses

Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal–fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110–130g/L, received 40 or 80mg iron daily) and Stratum 2 (Hb > 130g/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg/d instead of 40 mg/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg/d instead of 40 mg/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) ≥ 15 μg/L, while 40 mg/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy.

scholarly journals Maternal and neonatal 25‐hydroxyvitamin D concentrations and school‐age lung function, asthma and allergy. The Generation R Study

2019 ◽  
Vol 49 (6) ◽  
pp. 900-910 ◽  
Author(s):  
Sara M. Mensink‐Bout ◽  
Evelien R. Meel ◽  
Johan C. Jongste ◽  
Trudy Voortman ◽  
Irwin K. Reiss ◽  
...  
Keyword(s):  
Lung Function ◽  
School Age ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Asthma And Allergy

scholarly journals Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2221
Author(s):  
Hugo G. Quezada-Pinedo ◽  
Florian Cassel ◽  
Liesbeth Duijts ◽  
Martina U. Muckenthaler ◽  
Max Gassmann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Child Health ◽  
Methodological Quality ◽  
Iron Status ◽  
Meta Analysis ◽  
Child Health Outcomes ◽  
Maternal Iron ◽  
In Pregnancy

In pregnancy, iron deficiency and iron overload increase the risk for adverse pregnancy outcomes, but the effects of maternal iron status on long-term child health are poorly understood. The aim of the study was to systematically review and analyze the literature on maternal iron status in pregnancy and long-term outcomes in the offspring after birth. We report a systematic review on maternal iron status during pregnancy in relation to child health outcomes after birth, from database inception until 21 January 2021, with methodological quality rating (Newcastle-Ottawa tool) and random-effect meta-analysis. (PROSPERO, CRD42020162202). The search identified 8139 studies, of which 44 were included, describing 12,7849 mother–child pairs. Heterogeneity amongst the studies was strong. Methodological quality was predominantly moderate to high. Iron status was measured usually late in pregnancy. The majority of studies compared categories based on maternal ferritin, however, definitions of iron deficiency differed across studies. The follow-up period was predominantly limited to infancy. Fifteen studies reported outcomes on child iron status or hemoglobin, 20 on neurodevelopmental outcomes, and the remainder on a variety of other outcomes. In half of the studies, low maternal iron status or iron deficiency was associated with adverse outcomes in children. Meta-analyses showed an association of maternal ferritin with child soluble transferrin receptor concentrations, though child ferritin, transferrin saturation, or hemoglobin values showed no consistent association. Studies on maternal iron status above normal, or iron excess, suggest deleterious effects on infant growth, cognition, and childhood Type 1 diabetes. Maternal iron status in pregnancy was not consistently associated with child iron status after birth. The very heterogeneous set of studies suggests detrimental effects of iron deficiency, and possibly also of overload, on other outcomes including child neurodevelopment. Studies are needed to determine clinically meaningful definitions of iron deficiency and overload in pregnancy.

The influence of high-altitude living on body iron

Blood ◽  
2005 ◽  
Vol 106 (4) ◽  
pp. 1441-1446 ◽  
Author(s):  
James D. Cook ◽  
Erick Boy ◽  
Carol Flowers ◽  
Maria del Carmen Daroca
Keyword(s):  
Standard Error ◽  
Transferrin Receptor ◽  
Quantitative Assessment ◽  
Iron Status ◽  
Dietary Iron ◽  
Body Iron ◽  
Iron Stores ◽  
Iron Deficient ◽  
Iron Based ◽  
Maternal Iron

Abstract The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 ± 4.31 mg/kg (mean ± 1 SD) and 1.72 ± 4.53 mg/kg in children. No consistent effect of altitude on body iron was detected in children but body iron stores of 2.77 ± 0.70 mg/kg (mean ± 2 standard error [SE]) in women living above 3000 m was reduced by one-third compared with women living at lower altitudes (P < .001). One half of the children younger than 2 years were iron deficient, but iron stores then increased linearly to approach values in their mothers by 4 years of age. When body iron in mothers was compared with that of their children, a striking correlation was observed over the entire spectrum of maternal iron status (r = 0.61, P < .001). This finding could provide the strongest evidence to date of the importance of dietary iron as a determinant of iron status in vulnerable segments of a population. (Blood. 2005;106:1441-1446)

Most early-treated children with perinatally-acquired HIV have preserved lung function at school age

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Engi F. Attia ◽  
Hellen Moraa ◽  
Elizabeth Maleche-Obimbo ◽  
Dalton Wamalwa ◽  
Laurén A. Gómez ◽  
...  
Keyword(s):  
Lung Function ◽  
School Age ◽  
Perinatally Acquired

scholarly journals Neonatal and maternal iron status, but not serum folate, is related to placental expression of the proton coupled folate transporter (PCFT)

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Chang Cao ◽  
Thomas Bemis ◽  
Melissa Young ◽  
Thomas McNanley ◽  
Elizabeth Cooper ◽  
...  
Keyword(s):  
Iron Status ◽  
Serum Folate ◽  
Maternal Iron

scholarly journals How much Antenatal Supplemental Iron is Required to Preserve Maternal Iron Status? The MINIMat Intervention trial in Bangladesh

2015 ◽  
Vol 5 (5) ◽  
pp. 1167-1168
Author(s):  
Shirin Ziaei ◽  
Anisur Rahman ◽  
Shams Arifeen ◽  
Eva-Charlotte Ekström
Keyword(s):  
Iron Status ◽  
Intervention Trial ◽  
Maternal Iron
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