scholarly journals Exploring the relationship between maternal iron status and offspring’s blood pressure and adiposity: a Mendelian randomization study

2012 ◽  
pp. 193 ◽  
Author(s):  
Nisreen Alwan ◽  
Lawlor ◽  
McArdle ◽  
Greenwood ◽  
Cade
Keyword(s):  
Blood Pressure ◽  
Mendelian Randomization ◽  
Iron Status ◽  
The Relationship ◽  
Maternal Iron

scholarly journals Blood Pressure and Risk of Atrial Fibrillation: A Mendelian Randomization Study

2020 ◽  
Author(s):  
Matthew Craig Hyman ◽  
Michael Craig Levin ◽  
Dipender Gill ◽  
Venexia Walker ◽  
Marios K Georgakis ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Calcium Channel ◽  
Mendelian Randomization ◽  
European Ancestry ◽  
Summary Statistics ◽  
Uk Biobank ◽  
International Consortium ◽  
The Impact ◽  
The Relationship

Abstract Importance: Observational studies have shown an association between hypertension and atrial fibrillation (AF). Aggressive blood pressure management in patients with known AF reduces overall arrhythmia burden, but it remains unclear whether hypertension is causative for AF. Objective: The primary objective of this study was to investigate the relationship between blood pressure and risk of AF using genetic proxies for blood pressure within a Mendelian randomization (MR) framework. We secondarily explored the relationship between genetically proxied use of anti-hypertensive drugs and risk of AF. Design: Two-sample MR was performed using an inverse-variance weighted meta-analysis with weighted median MR and Egger intercept tests performed as sensitivity analyses. Genetic proxies for the anti-hypertensive drug classes were used to investigate the impact of these therapies on the risk of AF. Setting: International Consortium of Blood Pressure, UK Biobank and Atrial Fibrillation Genetics Consortium. Participants: Summary statistics for systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) were obtained from the International Consortium of Blood Pressure and the UK Biobank discovery analysis (>750,000 individuals of European ancestry). Summary statistics for AF were obtained from the 2018 Atrial Fibrillation Genetics Consortium multi-ethnic GWAS (>65,000 AF cases and >522,000 referents). Exposure: Genetically predicted SBP, DBP and PP as quantified by risk scores. Main Outcome: Odds ratio for AF per 10 mmHg increase in genetically proxied blood pressure. Results: Ten mmHg increases in genetically proxied SBP, DBP or PP were associated with increased odds of AF (SBP: OR 1.17, 95% CI 1.11-1.22, p=1x10-11; DBP: OR 1.25, 95% CI 1.16-1.35, p=3x10-8; PP: OR 1.1, 95% CI 1.0-1.2, p=0.05). Ten mmHg decreases in SBP estimated by genetic proxies of anti-hypertensive medications showed calcium channel blockers (OR 0.66, 95% CI 0.57-0.76, p=8x10-9) and beta-blockers (OR 0.61, 95% CI 0.46-0.81, p=6x10-4) decreased the risk of AF. Conclusions and Relevance: Blood pressure-increasing genetic variants were associated with increased risk of AF, consistent with a causal relationship between blood pressure and AF. These data support the concept that blood pressure reduction through pharmacologic intervention, and specifically calcium channel blockade or beta blockade could reduce the risk of AF.

scholarly journals Genetically Predicted Blood Pressure and Risk of Atrial Fibrillation

Hypertension ◽  
2021 ◽  
Author(s):  
Matthew C. Hyman ◽  
Michael G. Levin ◽  
Dipender Gill ◽  
Venexia M. Walker ◽  
Marios K. Georgakis ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Calcium Channel ◽  
Diastolic Blood Pressure ◽  
Pulse Pressure ◽  
Mendelian Randomization ◽  
Genome Wide Association Studies ◽  
Increased Risk ◽  
The Relationship

Observational studies have shown an association between hypertension and atrial fibrillation (AF). Aggressive blood pressure management in patients with known AF reduces overall arrhythmia burden, but it remains unclear whether hypertension is causative for AF. To address this question, this study explored the relationship between genetic predictors of blood pressure and risk of AF. We secondarily explored the relationship between genetically proxied use of antihypertensive drugs and risk of AF. Two-sample Mendelian randomization was performed using an inverse-variance weighted meta-analysis with weighted median Mendelian randomization and Egger intercept tests performed as sensitivity analyses. Summary statistics for systolic blood pressure, diastolic blood pressure, and pulse pressure were obtained from the International Consortium of Blood Pressure and the UK Biobank discovery analysis and AF from the 2018 Atrial Fibrillation Genetics Consortium multiethnic genome-wide association studies. Increases in genetically proxied systolic blood pressure, diastolic blood pressure, or pulse pressure by 10 mm Hg were associated with increased odds of AF (systolic blood pressure: odds ratio [OR], 1.17 [95% CI, 1.11–1.22]; P =1×10 −11 ; diastolic blood pressure: OR, 1.25 [95% CI, 1.16–1.35]; P =3×10 −8 ; pulse pressure: OR, 1.1 [95% CI, 1.0–1.2]; P =0.05). Decreases in systolic blood pressure by 10 mm Hg estimated by genetic proxies of antihypertensive medications showed calcium channel blockers (OR, 0.66 [95% CI, 0.57–0.76]; P =8×10 −9 ) and β-blockers (OR, 0.61 [95% CI, 0.46–0.81]; P =6×10 −4 ) decreased the risk of AF. Blood pressure–increasing genetic variants were associated with increased risk of AF, consistent with a causal relationship between blood pressure and AF. These data support the concept that blood pressure reduction with calcium channel blockade or β-blockade could reduce the risk of AF.

scholarly journals Maternal hypertension-related genes affect the fetal growth via placenta

2021 ◽  
Author(s):  
Noriko Sato ◽  
Ayako Fudono ◽  
Chihiro Imai ◽  
Hidemi Takimoto ◽  
Iori Tarui ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Metabolic Diseases ◽  
Mendelian Randomization ◽  
Maternal Blood ◽  
Low Birth Weight Infants ◽  
Maternal Hypertension ◽  
The Relationship ◽  
Maternal Blood Pressure

Abstract Low birth weight is associated with the development of cardio-metabolic diseases later in life1-4. A recent Mendelian Randomization Study concluded that the susceptibility of low-birth-weight infants to develop hypertension during adulthood is due to the inheritance of hypertension genes from the mother, and not to an unfavorable intrauterine environment5. Therein, it has been assumed that low birth weight is caused by maternal hypertension5,6, although there is no evidence to support such a linear relationship. In the present study, we have noted that most of blood pressure SNPs are related to vascular regulation7-9 and found that the relationship between maternal blood pressure-increasing polygenic score and reduction of offspring birth weight is mediated by a reduced growth of the placenta but not by the mother's high blood pressure. This suggests that the risk of hypertension of low-birth-weight infants may result from a poor placental environment.

scholarly journals Maternal iron intake and iron status during pregnancy and child blood pressure at age 3 years

2008 ◽  
Vol 37 (2) ◽  
pp. 301-308 ◽  
Author(s):  
M. B Belfort ◽  
S. L Rifas-Shiman ◽  
J. W Rich-Edwards ◽  
K. P Kleinman ◽  
E. Oken ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Iron Status ◽  
Iron Intake ◽  
Maternal Iron

Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Blood Lipids ◽  
The Other ◽  
The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

Risk assessment of occupational and occupationally conditioned diseases connection to noise when exceeding maximum permissible levels

2019 ◽  
pp. 17-19
Author(s):  
Vladimir A. Fokin ◽  
Dmitrii M. Shlyapnikov ◽  
Svetlana V. Red’ko
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
High Blood Pressure ◽  
Noise Exposure ◽  
Physical Factors ◽  
Autonomic Nervous ◽  
Permissible Levels ◽  
The Relationship ◽  
Perm Region

In accordance with the requirements of paragraph 3.2.6 of sanitary rules and norms «Sanitary and epidemiological requirements for physical factors at workplace», in the event of exceeding noise level at workplace above 80 dBA, an employer is obliged to assess the health risk of workers and confirm an acceptable risk to their health. The connection between the incidence of occupational and occupationally conditioned diseases with noise exposure exceeding the maximum permissible levels (80 dBA) was estimated. The assessment was carried out at a food industry enterprise of Perm Region. Assessing the relationship between morbidity and noise exposure is the first step in evaluation of occupational health risks for workers exposed to noise exceeding MAL. If a reliable relationship between morbidity and noise exposure is established, an assessment of occupational risk is conducted. The odds ratio (OR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1 (confidence interval CI=0.11–1.61 and CI=0.08–2.78, respectively). The relative risk (RR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1. The received data testify absence of connection of morbidity with exposure to industrial noise, calculation of etiological share of responses and levels of risk is not required.

Sign in / Sign up

Export Citation Format

Share Document