The effect of anti-inflammatory compounds on the biochemical changes in the Arthus reaction

1976 ◽  
Vol 119 (3) ◽  
pp. 175-182 ◽  
Author(s):  
K. Butler ◽  
G. P. Lewis
Keyword(s):  
Biochemical Changes ◽  
Arthus Reaction ◽  
Anti Inflammatory

Use of the reversed passive arthus reaction as a test for anti-inflammatory agents

1975 ◽  
Vol 5 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Marvin B. Goldlust ◽  
William F. Schreiber
Keyword(s):  
Arthus Reaction ◽  
Anti Inflammatory

scholarly journals Biochemical Changes of Myocardial Necrosis induced by Isoproterenol and Protective Effects of β-Blocker and Anti-inflammatory Drugs

1974 ◽  
Vol 22 (3) ◽  
pp. 669-675 ◽  
Author(s):  
TOSHIMICHI TSUBOI ◽  
KOHSAKU ISHIKAWA ◽  
YOSHIKO OHSAWA ◽  
KOUICHI YOSHIDA ◽  
MASANAO SHIMIZU
Keyword(s):  
Myocardial Necrosis ◽  
Biochemical Changes ◽  
Protective Effects ◽  
Β Blocker ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Anti-allergic and anti-inflammatory properties of Zizyphus mauritiana root bark

2015 ◽  
Vol 6 (9) ◽  
pp. 2975-2983 ◽  
Author(s):  
Suhas Talmale ◽  
Arti Bhujade ◽  
Mandakini Patil
Keyword(s):  
Complement System ◽  
Anaphylactic Shock ◽  
Root Bark ◽  
Arthus Reaction ◽  
Zizyphus Mauritiana ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
The Complement System ◽  
Cox 1

The MAF, a fraction with potent anti-allergic and anti-inflammatory compounds, is isolated fromZizyphus mauritianaroot bark. The MAF has an excellent ability to inhibit the complement system, COX-1, COX-2 and 5-LOX and has the potential to prevent anaphylactic shock and the Arthus reaction.

scholarly journals Clinical evaluation of postoperative analgesia and serum biochemical changes of paracetamol compared to meloxicam and carprofen in bitches undergoing ovariohysterectomy

2019 ◽  
Author(s):  
Ismael Hernández-Avalos ◽  
Alexander Valverde ◽  
José Antonio Ibancovichi-Camarillo ◽  
Pedro Sánchez-Aparicio ◽  
Sergio Recillas-Morales ◽  
...  
Keyword(s):  
Scoring Systems ◽  
Pain Scale ◽  
Biochemical Changes ◽  
Treatment Groups ◽  
Analgesic Effects ◽  
Group 4 ◽  
Surgical Pain ◽  
Serum Biochemical ◽  
Anti Inflammatory ◽  
The University

AbstractBackgroundIn veterinary medicine, the administration of nonsteroidal anti-inflammatory analgesics (NSAIDs) for the control of postsurgical pain in dogs and cats is common given the anti-inflammatory, analgesic, and antipyretic effects of these drugs. This study compared the serum biochemical changes and postoperative analgesic effects of paracetamol, meloxicam, and carprofen in bitches submitted to an ovariohysterectomy using the Dynamic Interactive Visual Analog Scale (DIVAS) and Pain Scale of the University of Melbourne (UMPS) scoring systems.MethodsThirty bitches of different breeds underwent elective ovariohysterectomies and were randomly assigned to one of three treatment groups: a paracetamol group [15 mg kg-1 intravenous (IV)], a carprofen group (4 mg kg-1 IV), and a meloxicam group (0.2 mg kg-1 IV). All treatments were administered 30 minutes prior to surgery. Paracetamol was administered every 8 hours postoperatively for 48 hours total, while carprofen and meloxicam were intravenously administered every 24 hours. An evaluation of post-surgical pain was done with the DIVAS and the UMPS. The first post-surgical pain measurement was performed 1 hour after surgery and then 2, 4, 6, 8, 12, 16, 20, 24, 36, and 48 hours after surgery.ResultsAll groups exhibited a gradual reduction in pain throughout the postoperative period in both scales; however, neither scale significantly differed between the three treatment groups (P > 0.05) during the 48 postoperative hours.ConclusionsParacetamol was as effective as meloxicam and carprofen for post-surgical analgesia in bitches subjected to elective ovariohysterectomy. The present study demonstrates that paracetamol may be considered a tool for the effective treatment of acute perioperative pain in dogs. Furthermore, this drug led to no adverse reactions or changes in the parameters assessed in the present study, indicating its safety.

scholarly journals Laboratory Indicators of Aggrecan Turnover in Juvenile Idiopathic Arthritis

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Katarzyna Winsz-Szczotka ◽  
Kornelia Kuźnik-Trocha ◽  
Katarzyna Komosińska-Vassev ◽  
Agnieszka Jura-Półtorak ◽  
Krystyna Olczyk
Keyword(s):  
Superoxide Dismutase ◽  
Juvenile Idiopathic Arthritis ◽  
Serum Level ◽  
Glutathione Peroxidase ◽  
Chondroitin Sulfate ◽  
Serum Levels ◽  
Biochemical Changes ◽  
Early Marker ◽  
Before And After ◽  
Anti Inflammatory

Objectives. Evaluation of chondroitin sulfate (CS), as an early marker of aggrecan degradation, and chondroitin sulfate 846 epitope (CS846), as a biomarker of CS synthesis, is an attempt at answering the question whether the therapy used in juvenile idiopathic arthritis (JIA) patients contributes to the normalization of biochemical changes in aggrecan.Methods and Results. Serum levels of CS and CS846 as well as catalase (CT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in erythrocyte were assessed in patients before and after treatment. In the course of JIA, aggrecan metabolism is disturbed, which is reflected by a decrease (p<0.001) in CS serum level and an increase (p<0.05) in CS846 concentration. Furthermore, increased (p<0.001) activities of CT, SOD, and GPx in untreated JIA patients were recorded. The anti-inflammatory treatment resulted in the normalization of CS846 level and SOD and GPx activities. In untreated patients, we have revealed a significant correlation between serum CS and CS846, CT, CRP, ESR, MMP-3, and ADAMTS-4, respectively, as well as between CS846 and CT, GPx, CRP, ESR, and TGF-β1, respectively.Conclusion. The observed changes of CS and CS846 in JIA patients indicate a further need of the therapy continuation aimed at protecting a patient from a possible disability.

The Arthus reaction in guinea-pig knee joints. A test for anti-inflammatory drugs

1975 ◽  
Vol 5 (5) ◽  
pp. 519-527 ◽  
Author(s):  
Alan Blackham ◽  
Henryk Radziwonik ◽  
Ian H. Shaw
Keyword(s):  
Guinea Pig ◽  
Knee Joints ◽  
Arthus Reaction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS

1954 ◽  
Vol 99 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Alvin F. Coburn ◽  
Joan Haninger
Keyword(s):  
Guinea Pig ◽  
Rheumatic Fever ◽  
Experimental Model ◽  
Inflammatory Process ◽  
Sodium Salicylate ◽  
Tissue Injury ◽  
Experimental Arthritis ◽  
Arthus Reaction ◽  
Inflammatory Agent ◽  
Anti Inflammatory

The passive Arthus arthritis in the guinea pig provides an experimental model for studying reactions comparable to those which occur in rheumatic fever. The joint swelling in the Arthus reaction is followed by tissue injury which is reflected 24 hours later by a rise in the DPA level. The height of this rise is determined by the degree of injury, which in turn is determined both by the strength of the antibody injected and also by the number of antigen depots created. The swelling reaction and the DPA rise can be suppressed by sodium salicylate, cortisone, or splenin A. The amount of drug required to block a DPA rise (DPA unit) is approximately tenfold the amount required to inhibit the joint swelling by 50 per cent (Arthus unit). Even when the Arthus arthritis has completed the swelling phase, treatment with appropriate amounts of these drugs suppress a rise in DPA. It was pointed out that the DPA rise appears to be associated with the tissue injury that follows joint swelling; that the degree of a DPA rise is determined by the severity of the inflammatory process; and that the amount of an anti-inflammatory agent required to suppress a DPA rise depends on the intensity of the reaction.

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