scholarly journals Biochemical Changes of Myocardial Necrosis induced by Isoproterenol and Protective Effects of β-Blocker and Anti-inflammatory Drugs

1974 ◽  
Vol 22 (3) ◽  
pp. 669-675 ◽  
Author(s):  
TOSHIMICHI TSUBOI ◽  
KOHSAKU ISHIKAWA ◽  
YOSHIKO OHSAWA ◽  
KOUICHI YOSHIDA ◽  
MASANAO SHIMIZU
Keyword(s):  
Myocardial Necrosis ◽  
Biochemical Changes ◽  
Protective Effects ◽  
Β Blocker ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals A Review on the Effects of Melatonin on Fetal Protection during Pregnancy with Intrauterine Inflammation

2020 ◽  
Vol 24 (4) ◽  
pp. 196-203
Author(s):  
Jang Mee Kim ◽  
Ji Yeon Lee
Keyword(s):  
Oxidative Stress ◽  
Pregnant Women ◽  
Animal Studies ◽  
Protective Effects ◽  
Fetal Protection ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Brain ◽  
Fetal Inflammatory Response

Intrauterine inflammation is defined as the inflammation of the chorion, amnion, and placenta. Untreated inflammation increases the risk of fetal inflammatory response syndrome, which may result in multiorgan diseases involving the brain, cardiovascular system, lung, eye, and intestine. Therefore, controlling inflammation is critical in pregnant women to reduce the risk of diseases. However, there are no safe and effective anti-inflammatory drugs for administration during pregnancy. Although the primary function of melatonin is to control circadian rhythms, it has protective effects against cellular insults occurring from hypoxia, oxidative stress, and inflammation. While animal studies support the effective and safe role of melatonin in improving pregnancy-related morbidities, it leaves plenty of opportunities for clinical studies investigating its anti-inflammatory, antioxidant, and protective effects against insults induced by intrauterine inflammation. Therefore, it will be worthwhile to investigate antenatal supplementation of melatonin in pregnant women with intrauterine inflammation to reduce the incidence of associated comorbidities.

Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review

Oral Oncology ◽  
2018 ◽  
Vol 85 ◽  
pp. 68-81 ◽  
Author(s):  
Constanza Saka Herrán ◽  
Enric Jané-Salas ◽  
Albert Estrugo Devesa ◽  
José López-López
Keyword(s):  
Systematic Review ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Protective Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Protective Effects of Garlic Extract, PMK-S005, Against Nonsteroidal Anti-inflammatory Drugs–Induced Acute Gastric Damage in Rats

2014 ◽  
Vol 59 (12) ◽  
pp. 2927-2934 ◽  
Author(s):  
Yoon Jeong Choi ◽  
Nayoung Kim ◽  
Ju Yup Lee ◽  
Ryoung Hee Nam ◽  
Hyun Chang ◽  
...  
Keyword(s):  
Garlic Extract ◽  
Gastric Damage ◽  
Protective Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Basic mechanisms of the cellular alterations in T-2 toxin poisoning: Influence on the choice and result of the therapy

2007 ◽  
pp. 45-53 ◽  
Author(s):  
Vesna Jacevic ◽  
Aleksandra Bocarov-Stancic ◽  
Radmila Resanovic ◽  
Snezana Djordjevic ◽  
Dubravko Bokonjic ◽  
...  
Keyword(s):  
Protective Effect ◽  
Protective Efficacy ◽  
Protective Effects ◽  
Trichothecene Mycotoxin ◽  
Dividing Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Significant Protective Effect ◽  
Cellular Alterations ◽  
Fusarium Fungi

T-2 mycotoxin, secondary metabolite of Fusarium fungi, is one of the most potent cytotoxic representatives of trichothecene mycotoxin type A. After ingestion, T-2 toxin affects actively dividing cells and irreversible post-mitotic cells. In our experiments, the best protective effects were produced by dexametasone (PI = 3.37) and different methylprednisolone formulations (PI = 2.43-2.64). Significant protective efficacy was shown by nimesulide (PI = 1.44) and N-acethyilcistein (PI = 1.29), but their values were higher in a combination with methylprednisolone (PI = 2.16-2.34). Radioprotector amifostine (WR-2721) expressed good protective effects (PI = 1.26) or/and different absorbent formulations, such as: activated charcoal (PI = 1.13) and various Min-a-zel? powder compounds, which are a well known zeolite clinoptilolite absorbents. Among the five zeolite regimens investigated, only Min-a-zel Plus? showed a significant protective effect (PI = 1.77). In summary, the steroidal anti-inflammatory drugs could be recommended as a regimen of choice for treatment of acute T-2 toxicosis while nonsteroidal anti-inflammatory compounds, different absorbent formulations and their combinations with antioxidants or radioprotectors could be important for the treatment of subacute and chronic T-2 toxin poisonings.

scholarly journals A review on therapeutic effect of non bio-fermented and bio-fermented product of various herbal drugs in the treatment of gastric ulcer

2020 ◽  
Vol 9 (2) ◽  
pp. 1042-1048
Keyword(s):  
Fast Food ◽  
Herbal Medicines ◽  
Streptococcus Thermophilus ◽  
Gastric Ulcers ◽  
Protective Effects ◽  
Herbal Drugs ◽  
Fermented Product ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fermented Products

The plan of this study is to find out the effect of several non Bio-fermented and Bio-fermented product of the various herbal drugs in health promotion. Many traditional medicines were shown to have anti-ulcer activity by using aqueous and non–aqueous solvents and probiotics. Micro-organisms such as Weissella cibaria, Saccharomyces cerevisiae, Bifidobacterium, lactobacillus and Streptococcus thermophilus which are already use in bio-fermentation of herbal medicines. Non-steroidal anti-inflammatory drugs have painkiller, anti-inflammatory as well as anti-pyretic properties. These drugs have a side effect of gastric ulcers by inhibition of COX enzymes and reduce the prostaglandin secretion resulting in luminal aggression that induces stomach ulcers. Various Non- steroidal anti-inflammatory drugs inhibit both enzymes COX-1 and COX-2 further categorized as non-selective inhibitors. Stress, eating fast food, consuming more alcohol and busy lifestyles are common causes of gastric ulcers. Probiotics are good for the intestine and stomach because they increase the secretion of prostaglandin (PGE-2) in the mucus membrane, changes the pH of intestine and improve the digestion in the gastro intestinal tract. This study focuses the bio-fermentation of herbal medicines through various microbes. It also suggests that anti-ulcer activity of bio-fermented products is more dynamic than for non bio-fermented products. Here, we suggest that bio-fermented product of herbals shows protective effects in gastric ulcers.

Ankylosing Spondylitis: A Risk Factor for Parkinsonism—A Nationwide Population-Based Study

2021 ◽  
pp. 1-8
Author(s):  
Seo Yeon Yoon ◽  
Seok-Jae Heo ◽  
Yong Wook Kim ◽  
Seung Nam Yang ◽  
Hyun-Im Moon
Keyword(s):  
Ankylosing Spondylitis ◽  
Population Based ◽  
Atypical Parkinsonism ◽  
Protective Effects ◽  
Subdistribution Hazard ◽  
Neurodegenerative Process ◽  
Immune Mediated ◽  
Increased Risk ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Ankylosing spondylitis (AS) is an immune-mediated, chronic inflammatory rheumatic disorder. The etiology of Parkinson’s disease (PD) is multifactorial; however, inflammation is receiving an increasing amount of attention as an underlying cause of the neurodegenerative process of PD. Objective: We performed a nationwide longitudinal, population-based matched cohort study to assess the association with the later development of parkinsonism in Korea. Methods: This study was conducted using records from the Health Insurance Review and Assessment Service database. The cumulative incidence rate of PD was estimated. Fine–Gray subdistribution hazard models were used to identify hazards associated with PD development based on the presence of AS. Exposure to anti-inflammatory drugs was measured and analyzed to determine the protective effect of these medications. Additionally, the hazard ratio (HR) for atypical parkinsonism was estimated. Results: The results of the Fine–Gray subdistribution hazard model revealed that the HR for PD development in the AS group was 1.82 (95%confidence interval [CI], 1.38–2.39, p <  0.001). A significant decrease in PD development was observed in patients with AS taking non-steroidal anti-inflammatory drugs (NSAIDs). The HR for atypical parkinsonism in the AS group was 3.86 (95%CI, 1.08–13.78, p <  0.05). Conclusion: We found that AS was associated with an increased risk of PD and atypical parkinsonism. NSAIDs used for AS control have some protective effects against PD. Further studies assessing whether biological treatment mitigates PD risk in patients with high activity are warranted.

scholarly journals Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms

2021 ◽  
Vol 23 (5) ◽  
Author(s):  
Zhenjie Huang ◽  
Peng Wei ◽  
Luoman Gan ◽  
Wentao Li ◽  
Tonghua Zeng ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Protective Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Paul-Mihai Boarescu ◽  
Ioana Chirilă ◽  
Adriana E. Bulboacă ◽  
Ioana Corina Bocșan ◽  
Raluca Maria Pop ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Histopathological Examination ◽  
Cardiac Injury ◽  
Myocardial Necrosis ◽  
Neutrophil Infiltration ◽  
Protective Effects ◽  
Curcumin Nanoparticles ◽  
White Rats ◽  
Creatine Kinase Mb ◽  
Anti Inflammatory

Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional curcumin (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats. Fifty-six Wistar-Bratislava white rats were randomly divided into eight groups of seven rats each. Curcumin and curcumin nanoparticles were given by gavage in three different doses (100 mg/kg body weight (bw), 150 mg/kg bw, and 200 mg/kg bw) for 15 days. The MI was induced on day 13 using 100 mg/kg bw ISO administered twice, with the second dose 24 h after the initial dose. The blood samples were taken 24 h after the last dose of ISO. The antioxidant, anti-inflammatory, and cardioprotective effects were evaluated in all groups. All doses of CC and CCNP offered a cardioprotective effect by preventing creatine kinase-MB leakage from cardiomyocytes, with the best result for CCNP. All the oxidative stress parameters were significantly improved after CCNP compared to CC pretreatment. CCNP was more efficient than CC in limiting the increase in inflammatory cytokine levels (such as TNF-α, IL-6, IL-1α, IL-1β, MCP-1, and RANTES) after MI. MMP-2 and MMP-9 levels decreased more after pretreatment with CCNP than with CC. CCNP better prevented myocardial necrosis and reduced interstitial edema and neutrophil infiltration than CC, on histopathological examination. Therefore, improving the bioactivity of curcumin by nanotechnology may help limit cardiac injury after myocardial infarction.

scholarly journals Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing and Osseointegration: the Need for large Scale Human Clinical Trials

2021 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Bone Healing ◽  
Large Scale ◽  
Human Subjects ◽  
Protective Effects ◽  
Quantitative Measurements ◽  
Ensure Patient Safety ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Administration Timing

This article revisits the topic whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) affect bone healing and osseointegration. An understanding on this topic is crucial for clinicians to make evidence-based decisions to ensure patient safety and long-term success of implants. Based on authors’ systematic search, a limited number of articles were found to merit another systematic review. The understanding on the effects of NSAIDs on bone, specifically in human subjects, and the underlying biochemical mechanism, remain limited, owing to design variations in limited published studies. Some studies may suggest NSAIDs have no adverse,if not protective effects. One can suggest that a combination of certain NSAID type, dosage, administration timing and duration may adversely affect bone. Authors would like to raise awareness and highlight the need of collective efforts and further studies with standardised quantitative measurements to help our understanding of the effects of this commonly used line of treatment

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