Use of the reversed passive arthus reaction as a test for anti-inflammatory agents

1975 ◽  
Vol 5 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Marvin B. Goldlust ◽  
William F. Schreiber
Keyword(s):  
Arthus Reaction ◽  
Anti Inflammatory

Anti-allergic and anti-inflammatory properties of Zizyphus mauritiana root bark

2015 ◽  
Vol 6 (9) ◽  
pp. 2975-2983 ◽  
Author(s):  
Suhas Talmale ◽  
Arti Bhujade ◽  
Mandakini Patil
Keyword(s):  
Complement System ◽  
Anaphylactic Shock ◽  
Root Bark ◽  
Arthus Reaction ◽  
Zizyphus Mauritiana ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
The Complement System ◽  
Cox 1

The MAF, a fraction with potent anti-allergic and anti-inflammatory compounds, is isolated fromZizyphus mauritianaroot bark. The MAF has an excellent ability to inhibit the complement system, COX-1, COX-2 and 5-LOX and has the potential to prevent anaphylactic shock and the Arthus reaction.

The Arthus reaction in guinea-pig knee joints. A test for anti-inflammatory drugs

1975 ◽  
Vol 5 (5) ◽  
pp. 519-527 ◽  
Author(s):  
Alan Blackham ◽  
Henryk Radziwonik ◽  
Ian H. Shaw
Keyword(s):  
Guinea Pig ◽  
Knee Joints ◽  
Arthus Reaction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS

1954 ◽  
Vol 99 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Alvin F. Coburn ◽  
Joan Haninger
Keyword(s):  
Guinea Pig ◽  
Rheumatic Fever ◽  
Experimental Model ◽  
Inflammatory Process ◽  
Sodium Salicylate ◽  
Tissue Injury ◽  
Experimental Arthritis ◽  
Arthus Reaction ◽  
Inflammatory Agent ◽  
Anti Inflammatory

The passive Arthus arthritis in the guinea pig provides an experimental model for studying reactions comparable to those which occur in rheumatic fever. The joint swelling in the Arthus reaction is followed by tissue injury which is reflected 24 hours later by a rise in the DPA level. The height of this rise is determined by the degree of injury, which in turn is determined both by the strength of the antibody injected and also by the number of antigen depots created. The swelling reaction and the DPA rise can be suppressed by sodium salicylate, cortisone, or splenin A. The amount of drug required to block a DPA rise (DPA unit) is approximately tenfold the amount required to inhibit the joint swelling by 50 per cent (Arthus unit). Even when the Arthus arthritis has completed the swelling phase, treatment with appropriate amounts of these drugs suppress a rise in DPA. It was pointed out that the DPA rise appears to be associated with the tissue injury that follows joint swelling; that the degree of a DPA rise is determined by the severity of the inflammatory process; and that the amount of an anti-inflammatory agent required to suppress a DPA rise depends on the intensity of the reaction.

Sign in / Sign up

Export Citation Format

Share Document