Cerebral blood oxygenation in rat brain during hypoxic hypoxia. Quantitative MRI of effective transverse relaxation rates

1994 ◽  
Vol 31 (6) ◽  
pp. 678-681 ◽  
Author(s):  
Franz Prielmeier ◽  
Yasushi Nagatomo ◽  
Jens Frahm
Keyword(s):  
Rat Brain ◽  
Blood Oxygenation ◽  
Quantitative Mri ◽  
Hypoxic Hypoxia ◽  
Relaxation Rates ◽  
Transverse Relaxation ◽  
Cerebral Blood Oxygenation

Hypoxic hypoxia induces different biochemical changes in the cortex of the right and left hemispheres of rat brain

1995 ◽  
Vol 25 (2-3) ◽  
pp. 255-263 ◽  
Author(s):  
N. Nalivaeva ◽  
A. Plesneva ◽  
U. Chekulaeva ◽  
I. Zhuravin ◽  
N. Dubrovskaya ◽  
...  
Keyword(s):  
Rat Brain ◽  
Biochemical Changes ◽  
Hypoxic Hypoxia ◽  
The Right

Magnetic Resonance Imaging of Regional Cerebral Blood Oxygenation Changes Under Acetazolamide in Carotid Occlusive Disease

Stroke ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 106-110 ◽  
Author(s):  
Andreas Kleinschmidt ◽  
Helmuth Steinmetz ◽  
Matthias Sitzer ◽  
Klaus-Dietmar Merboldt ◽  
Jens Frahm
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Blood Oxygenation ◽  
Occlusive Disease ◽  
Resonance Imaging ◽  
Regional Cerebral Blood ◽  
Carotid Occlusive Disease ◽  
Cerebral Blood Oxygenation

scholarly journals Transverse relaxation rates of pulmonary dissolved‐phase Hyperpolarized 129 Xe as a biomarker of lung injury in idiopathic pulmonary fibrosis

2020 ◽  
Vol 84 (4) ◽  
pp. 1857-1867
Author(s):  
Jeff Kammerman ◽  
Andrew D. Hahn ◽  
Robert V. Cadman ◽  
Annelise Malkus ◽  
David Mummy ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Injury ◽  
Relaxation Rates ◽  
Transverse Relaxation ◽  
Dissolved Phase

scholarly journals In Vivo Quantification of Cerebral R2*-Response to Graded Hyperoxia at 3 Tesla

2015 ◽  
Vol 5 ◽  
pp. 1 ◽  
Author(s):  
Grigorios Gotzamanis ◽  
Roman Kocian ◽  
Pinar S. Özbay ◽  
Manuel Redle ◽  
Spyridon Kollias ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Relaxation Rate ◽  
Tumor Therapy ◽  
Cerebrovascular Reactivity ◽  
Oxygen Intake ◽  
Transverse Relaxation Rate ◽  
Dependent Manner ◽  
Relaxation Rates ◽  
Transverse Relaxation ◽  
Arterial Blood

Objectives: This study aims to quantify the response of the transverse relaxation rate of the magnetic resonance (MR) signal of the cerebral tissue in healthy volunteers to the administration of air with step-wise increasing percentage of oxygen. Materials and Methods: The transverse relaxation rate (R2*) of the MR signal was quantified in seven volunteers under respiratory intake of normobaric gas mixtures containing 21, 50, 75, and 100% oxygen, respectively. End-tidal breath composition, arterial blood saturation (SaO2), and heart pulse rate were monitored during the challenge. R2* maps were computed from multi-echo, gradient-echo magnetic resonance imaging (MRI) data, acquired at 3.0T. The average values in the segmented white matter (WM) and gray matter (GM) were tested by the analysis of variance (ANOVA), with Bonferroni post-hoc correction. The GM R2*-reactivity to hyperoxia was modeled using the Hill's equation. Results: Graded hyperoxia resulted in a progressive and significant (P < 0.05) decrease of the R2* in GM. Under normoxia the GM-R2* was 17.2 ± 1.1 s-1. At 75% O2 supply, the R2* had reached a saturation level, with 16.4 ± 0.7 s-1 (P = 0.02), without a significant further decrease for 100% O2. The R2*-response of GM correlated positively with CO2 partial pressure (R = 0.69 ± 0.19) and negatively with SaO2 (R = -0.74 ± 0.17). The WM showed a similar progressive, but non-significant, decrease in the relaxation rates, with an increase in oxygen intake (P = 0.055). The Hill's model predicted a maximum R2* response of the GM, of 3.5%, with half the maximum at 68% oxygen concentration. Conclusions: The GM-R2* responds to hyperoxia in a concentration-dependent manner, suggesting that monitoring and modeling of the R2*-response may provide new oxygenation biomarkers for tumor therapy or assessment of cerebrovascular reactivity in patients.

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