Hypoxic hypoxia induces different biochemical changes in the cortex of the right and left hemispheres of rat brain

1995 ◽  
Vol 25 (2-3) ◽  
pp. 255-263 ◽  
Author(s):  
N. Nalivaeva ◽  
A. Plesneva ◽  
U. Chekulaeva ◽  
I. Zhuravin ◽  
N. Dubrovskaya ◽  
...  
Keyword(s):  
Rat Brain ◽  
Biochemical Changes ◽  
Hypoxic Hypoxia ◽  
The Right

Oxygen insufficiency during hypoxic hypoxia in rat brain cortex

1984 ◽  
Vol 293 (2) ◽  
pp. 313-318 ◽  
Author(s):  
Joseph C. LaManna ◽  
Andrew I. Light ◽  
Samuel J. Peretsman ◽  
Myron Rosenthal
Keyword(s):  
Rat Brain ◽  
Brain Cortex ◽  
Hypoxic Hypoxia ◽  
Rat Brain Cortex

scholarly journals Rat brain microsomal gangliosides. Accessibility to a neuraminidase preparation and the possible existence of different pools in relation to their biosynthesis

1974 ◽  
Vol 138 (2) ◽  
pp. 291-298 ◽  
Author(s):  
H. J. F. Maccioni ◽  
A. Arce ◽  
C. Landa ◽  
R. Caputto
Keyword(s):  
Rat Brain ◽  
Chemical Structure ◽  
Proper Position ◽  
Neuraminidase Treatment ◽  
Acetylneuraminic Acid ◽  
Microsomal Membranes ◽  
Labelling Experiment ◽  
Labile N ◽  
The Right

1. Treatment of rat brain microsomal membranes with a neuraminidase preparation from Clostridium perfringens resulted in an almost complete conversion of polysialogangliosides into monosialogangliosides. 2. Neuraminidase treatment of the membranes did not increase the incorporation of N-[3H]acetylneuraminic acid from CMP-N-[3H]acetylneuraminic acid into the gangliosidic fraction, indicating that a monosialoganglioside is an acceptor of N-acetylneuraminic acid in these membranes only if, in addition to having the right chemical structure, it is in a proper position, probably in relation to the endogenous sialyltransferases. 3. These experiments also indicated that no independent turnover of the neuraminidase-labile N-acetylneuraminyl groups of gangliosides occurred in vitro. 4. N-[3H]Acetylneuraminic acid from endogenous polysialogangliosides labelled in vitro was released by neuraminidase at a slower rate than N-acetylneuraminic acid from unlabelled gangliosides of the same membranes. From this it was concluded that recently synthesized polysialogangliosides (completed in vitro) are in the membranes in a position less accessible to neuraminidase than are those synthesized earlier which were present in the membranes at the start of the labelling experiment.

1-Methyl-1,2,3,4-tetrahydroisoquinoline protects against rotenone-induced mortality and biochemical changes in rat brain

2003 ◽  
Vol 466 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Lucyna Antkiewicz-Michaluk ◽  
Beata Karolewicz ◽  
Irena Romańska ◽  
Jerzy Michaluk ◽  
Andrzej J. Bojarski ◽  
...  
Keyword(s):  
Rat Brain ◽  
Biochemical Changes

scholarly journals Biochemical Changes in Experimental Rat Brain Tumors Induced by Ethylnitrosourea and Human Gliomas after Dibutyryl Cyclic AMP Treatment

1982 ◽  
Vol 22 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Iekado SHIBATA ◽  
Mikiro MATSUMOTO ◽  
Sadatsugu NAGASAWA ◽  
Yoshikatsu SEIKI ◽  
Junichi TAKEZAWA
Keyword(s):  
Cyclic Amp ◽  
Brain Tumors ◽  
Rat Brain ◽  
Biochemical Changes ◽  
Dibutyryl Cyclic Amp ◽  
Human Gliomas

scholarly journals Effect of Astrocytic Energy Metabolism Depressant on 14C-Acetate Uptake in Intact Rat Brain

2004 ◽  
Vol 24 (2) ◽  
pp. 188-190 ◽  
Author(s):  
Rie Hosoi ◽  
Maki Okada ◽  
Jun Hatazawa ◽  
Antony Gee ◽  
Osamu Inoue
Keyword(s):  
Blood Flow ◽  
Energy Metabolism ◽  
Rat Brain ◽  
Regional Blood Flow ◽  
Regional Distribution ◽  
Acetate Uptake ◽  
Minute Period ◽  
Intact Brain ◽  
The Right

Fluorocitrate, a selective astrocytic toxin, was microinjected into the right striatum of rat brain, and the regional distribution of 14C-acetate was measured using autoradiography. A significant reduction (more than 80%) in 14C-acetate uptake over a 5-minute period was observed in the right striatum, compared with that in the left striatum (saline infused), 4 hours after fluorocitrate (1 nmol/μL) infusion. This effect was transient, and 14C-acetate uptake had almost returned to normal at 24 hours after the fluorocitrate infusion. In contrast, the regional blood flow in the striatum, as determined using 14C-iodoamphetamine, was significantly increased by the fluorocitrate infusion. The present observations indicate that 14C-acetate uptake might be a useful characteristic for examining astrocytic energy metabolism in the intact brain.

Application of high field localisedin vivo1H MRS to study biochemical changes in the thiamin deficient rat brain under glucose load

1993 ◽  
Vol 6 (5) ◽  
pp. 324-328 ◽  
Author(s):  
S. E. Rose ◽  
P. F. Nixon ◽  
F. O. Zelaya ◽  
B. T. Wholohan ◽  
C. Zimitat ◽  
...  
Keyword(s):  
Rat Brain ◽  
High Field ◽  
Biochemical Changes ◽  
Glucose Load

scholarly journals Hypoxia—Ischemia Induces a Rapid Elevation of Ubiquitin Conjugate Levels and Ubiquitin Immunoreactivity in the Immature Rat Brain

1998 ◽  
Vol 18 (4) ◽  
pp. 376-385 ◽  
Author(s):  
Susan J. Vannucci ◽  
Rosemary Mummery ◽  
Richard B. Hawkes ◽  
Christopher C. Rider ◽  
Philip W. Beesley
Keyword(s):  
Rat Brain ◽  
Control Level ◽  
Artery Ligation ◽  
Western Blots ◽  
Immature Rat ◽  
Carotid Artery Ligation ◽  
Hypoxia Ischemia ◽  
The Right ◽  
Ubiquitin Conjugate ◽  
Postnatal Rats

Postnatal rats at 7 and 21 days of age were subjected to unilateral hypoxia—ischemia (H/I) by right carotid artery ligation followed by 1.5 to 2 hours of hypoxia (8% oxygen). Brains were frozen at specific intervals of recovery from 0 to 24 hours. Western blots of samples of right and left forebrain were immunodeveloped with a monoclonal antibody specific for ubiquitin, RHUb 1. An elevation of ubiquitin conjugate levels in the right compared with the left forebrain of 7-day-old animals was detectable immediately following H/I and increased by close to 60% of control level within 1 hour of recovery. The conjugate immunoreactivity remained at this level for 6 hours but had declined to control levels by 24 hours of recovery. No such increase was observed in response to hypoxia alone. Similar changes were observed in samples from the 21-day-old rat brain. However, the elevation of ubiquitin conjugate levels was of slower onset and persisted longer than observed for the 7-day-old animals. Immunocytochemical studies of brain fixed by immersion in formaldehyde/acetone/methanol showed that ubiquitin-like immunoreactivity was increased in the right, but not left, cerebral cortex and hippocampus of animals subjected to H/I. The data suggest that elevated ubiquitination may represent a neuroprotective response to H/I.

scholarly journals Role of ethanol on aluminum induced biochemical changes on rat brain

2006 ◽  
Vol 21 (2) ◽  
pp. 53-57 ◽  
Author(s):  
Parsunpriya Nayak ◽  
Subir Kumar Das ◽  
D. M. Vasudevan
Keyword(s):  
Rat Brain ◽  
Biochemical Changes
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