Polyhedral Oligomeric Silsesquioxane Hybrid Polymers: Well‐Defined Architectural Design and Potential Functional Applications

2019 ◽  
Vol 40 (17) ◽  
pp. 1900101 ◽  
Author(s):  
Fang Chen ◽  
Feng Lin ◽  
Qi Zhang ◽  
Rong Cai ◽  
Yadong Wu ◽  
...  
Keyword(s):  
Architectural Design ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Hybrid Polymers ◽  
Functional Applications ◽  
Oligomeric Silsesquioxane

Water soluble polyhedral oligomeric silsesquioxane based amphiphilic hybrid polymers: Synthesis, self-assembly, and applications

2016 ◽  
Vol 75 ◽  
pp. 67-92 ◽  
Author(s):  
Asad Ullah ◽  
Shakir Ullah ◽  
Gul Shehzada Khan ◽  
Syed Mujtaba Shah ◽  
Zakir Hussain ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Water Soluble ◽  
Hybrid Polymers ◽  
Oligomeric Silsesquioxane

Model Polyhedral Oligomeric Silsesquioxane Thin Films for Coating Applications

2002 ◽  
Author(s):  
Brent Viers ◽  
Shawn Phillips ◽  
Timothy Haddad ◽  
Alan Esker ◽  
Joe Polidan
Keyword(s):  
Thin Films ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Oligomeric Silsesquioxane

Polyhedral Oligomeric Silsesquioxane /Platelets Rich Plasma/Gelrite-Based Hydrogel Scaffold for Bone Tissue Engineering

2020 ◽  
Vol 26 (26) ◽  
pp. 3147-3160
Author(s):  
Saeedeh Ahmadipour ◽  
Jaleh Varshosaz ◽  
Batool Hashemibeni ◽  
Leila Safaeian ◽  
Maziar Manshaei
Keyword(s):  
Bone Fractures ◽  
Compressive Strain ◽  
Gelation Time ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Local Drug Delivery ◽  
Gelling Agent ◽  
Control Group ◽  
Hydrogel Scaffold ◽  
Alizarin Red ◽  
Oligomeric Silsesquioxane

Background: Polyhedral oligomeric silsesquioxane (POSS) is a monomer with silicon structure and an internal nanometric cage. Objective: The purpose of this study was to provide an injectable hydrogel that could be easily located in open or closed bone fractures and injuries, and also to reduce the possible risks of infections caused by bone graft either as an allograft or an autograft. Methods: Various formulations of temperature sensitive hydrogels containing hydroxyapatite, Gelrite, POSS and platelets rich plasma (PRP), such as the co-gelling agent and cell growth enhancer, were prepared. The hydrogels were characterized for their injectability, gelation time, phase transition temperature and viscosity. Other physical properties of the optimized formulation including compressive stress, compressive strain and Young’s modulus as mechanical properties, as well as storage and loss modulus, swelling ratio, biodegradation behavior and cell toxicity as rheometrical parameters were studied on human osteoblast MG-63 cells. Alizarin red tests were conducted to study the qualitative and quantitative osteogenic capability of the designed scaffold, and the cell adhesion to the scaffold was visualized by scanning electron microscopy. Results: The results demonstrated that the hydrogel scaffold mechanical force and injectability were 3.34±0.44 Mpa and 12.57 N, respectively. Moreover, the scaffold showed higher calcium granules production in alizarin red staining compared to the control group. The proliferation of the cells in G4.5H1P0.03PRP10 formulation was significantly higher than in other formulations (p<0.05). Conclusion: The optimized Gelrite/Hydroxyapatite/POSS/PRP hydrogel scaffold has useful impacts on osteoblasts activity, and may be beneficial for local drug delivery in complications including a break or bone loss.

Sign in / Sign up

Export Citation Format

Share Document