Stimuli-Sensitive Injectable Hydrogels Based on Polysaccharides and Their Biomedical Applications

2016 ◽  
Vol 37 (23) ◽  
pp. 1881-1896 ◽  
Author(s):  
Thavasyappan Thambi ◽  
V. H. Giang Phan ◽  
Doo Sung Lee
Keyword(s):  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Stimuli Sensitive

Injectable keratin hydrogels as hemostatic and wound dressing materials

2021 ◽  
Author(s):  
Ao Tang ◽  
Ying Li ◽  
Yiqian Yao ◽  
Xuexia Yang ◽  
Zhangjun Cao ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Good Biocompatibility ◽  
Dressing Materials ◽  
Administration Procedure ◽  
Wound Dressing Materials

Injectable hydrogels hold promise in biomedical applications due to their noninvasive administration procedure, and capacity enabling the filling of irregularly shaped defects. Protein-based hydrogels provide features including good biocompatibility and...

Self-assembled injectable biomolecular hydrogels towards phototherapy

Nanoscale ◽  
2019 ◽  
Vol 11 (46) ◽  
pp. 22182-22195 ◽  
Author(s):  
Ruirui Xing ◽  
Yamei Liu ◽  
Qianli Zou ◽  
Xuehai Yan
Keyword(s):  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Self Assembled

Supramolecular injectable hydrogels assembled from biomolecules, such as proteins, peptides, and polysaccharides, are promising candidates for facilitating biomedical applications towards antitumor and antibacterial phototherapies.

scholarly journals A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3050
Author(s):  
Yujie Chen ◽  
Runjing Zhang ◽  
Baiqin Zheng ◽  
Chao Cai ◽  
Zhen Chen ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Clinical Applications ◽  
Carboxymethyl Chitosan ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Covalent Bonds ◽  
Injectable Hydrogels ◽  
Handling Performance ◽  
Natural Polysaccharide

Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.

Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

2019 ◽  
Vol 7 (41) ◽  
pp. 6362-6369 ◽  
Author(s):  
Tomoki Nishimura ◽  
Naoki Sumi ◽  
Sada-atsu Mukai ◽  
Yoshihiro Sasaki ◽  
Kazunari Akiyoshi
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Self Healing ◽  
Injectable Hydrogels

An approach for the fabrication of self-healing injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is demonstrated.

Chitosan-based injectable hydrogels for biomedical applications

2016 ◽  
pp. 1-9
Author(s):  
K. Wang ◽  
G. Buschle-Diller ◽  
R. D. K. Misra
Keyword(s):  
Biomedical Applications ◽  
Injectable Hydrogels

Tough, In-Situ Thermogelling, Injectable Hydrogels for Biomedical Applications

2015 ◽  
Vol 15 (4) ◽  
pp. 473-480 ◽  
Author(s):  
Ghulam Jalani ◽  
Derek H. Rosenzweig ◽  
Georges Makhoul ◽  
Sherif Abdalla ◽  
Renzo Cecere ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Injectable Hydrogels

scholarly journals Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3383 ◽  
Author(s):  
Jie Zhu ◽  
Hua Han ◽  
Ting-Ting Ye ◽  
Fa-Xue Li ◽  
Xue-Li Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Hybrid Hydrogel ◽  
Antibacterial Studies ◽  
Hybrid Hydrogels ◽  
Stimuli Sensitive

The stimuli-sensitive and biodegradable hydrogels are promising biomaterials as controlled drug delivery systems for diverse biomedical applications. In this study, we construct hybrid hydrogels combined with peptide-based bis-acrylate and acrylic acid (AAc). The peptide-based bis-acrylate/AAc hybrid hydrogel displays an interconnected and porous structure by scanning electron microscopy (SEM) observation and exhibits pH-dependent swelling property. The biodegradation of hybrid hydrogels was characterized by SEM and weight loss, and the results showed the hydrogels have a good enzymatic biodegradation property. The mechanical and cytotoxicity properties of the hydrogels were also tested. Besides, triclosan was preloaded during the hydrogel formation for drug release and antibacterial studies. In summary, the peptide-based bis-acrylate/AAc hydrogel with stimuli sensitivity and biodegradable property may be excellent candidates as drug delivery systems for antibacterial wound dressing application.

Sign in / Sign up

Export Citation Format

Share Document