Polyethylene glycol (PEG)–Poly(N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications

2014 ◽  
Vol 88 (3) ◽  
pp. 575-585 ◽  
Author(s):  
Amit Alexander ◽  
Ajazuddin ◽  
Junaid Khan ◽  
Swarnlata Saraf ◽  
Shailendra Saraf
Keyword(s):  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Injectable Hydrogels

Injectable keratin hydrogels as hemostatic and wound dressing materials

2021 ◽  
Author(s):  
Ao Tang ◽  
Ying Li ◽  
Yiqian Yao ◽  
Xuexia Yang ◽  
Zhangjun Cao ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Good Biocompatibility ◽  
Dressing Materials ◽  
Administration Procedure ◽  
Wound Dressing Materials

Injectable hydrogels hold promise in biomedical applications due to their noninvasive administration procedure, and capacity enabling the filling of irregularly shaped defects. Protein-based hydrogels provide features including good biocompatibility and...

scholarly journals In silico study of PEI-PEG-squalene-dsDNA polyplex formation: The delicate role of PEG length to the binding of PEI to DNA

2021 ◽  
Author(s):  
Tudor Vasiliu ◽  
Bogdan Florin Florin Craciun ◽  
Andrei Neamtu ◽  
Lilia Clima ◽  
Dragos Lucian Isac ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polyethylene Glycol ◽  
Gene Delivery ◽  
In Silico ◽  
Biomedical Applications ◽  
Experimental Studies ◽  
Biomedical Devices ◽  
In Silico Study ◽  
Or Gene

The biocompatible hydrophilic polyethylene glycol (PEG) is widely used in biomedical applications, such as drug or gene delivery, tissue engineering or as antifouling in biomedical devices. Experimental studies have shown...

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

Self-assembled injectable biomolecular hydrogels towards phototherapy

Nanoscale ◽  
2019 ◽  
Vol 11 (46) ◽  
pp. 22182-22195 ◽  
Author(s):  
Ruirui Xing ◽  
Yamei Liu ◽  
Qianli Zou ◽  
Xuehai Yan
Keyword(s):  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Self Assembled

Supramolecular injectable hydrogels assembled from biomolecules, such as proteins, peptides, and polysaccharides, are promising candidates for facilitating biomedical applications towards antitumor and antibacterial phototherapies.

Polyethylene glycol-containing polyurethanes for biomedical applications

1998 ◽  
Vol 46 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Siska Corneillie ◽  
Pham Ngoc Lan ◽  
Etienne Schacht ◽  
Martyn Davies ◽  
Alex Shard ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Biomedical Applications

scholarly journals A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3050
Author(s):  
Yujie Chen ◽  
Runjing Zhang ◽  
Baiqin Zheng ◽  
Chao Cai ◽  
Zhen Chen ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Clinical Applications ◽  
Carboxymethyl Chitosan ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Covalent Bonds ◽  
Injectable Hydrogels ◽  
Handling Performance ◽  
Natural Polysaccharide

Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.

Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

2019 ◽  
Vol 7 (41) ◽  
pp. 6362-6369 ◽  
Author(s):  
Tomoki Nishimura ◽  
Naoki Sumi ◽  
Sada-atsu Mukai ◽  
Yoshihiro Sasaki ◽  
Kazunari Akiyoshi
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Self Healing ◽  
Injectable Hydrogels

An approach for the fabrication of self-healing injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is demonstrated.

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