scholarly journals A Biocompatible, Stimuli-Responsive, and Injectable Hydrogel with Triple Dynamic Bonds

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3050
Author(s):  
Yujie Chen ◽  
Runjing Zhang ◽  
Baiqin Zheng ◽  
Chao Cai ◽  
Zhen Chen ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Clinical Applications ◽  
Carboxymethyl Chitosan ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Covalent Bonds ◽  
Injectable Hydrogels ◽  
Handling Performance ◽  
Natural Polysaccharide

Injectable hydrogels have attracted growing interests as promising biomaterials for clinical applications, due to their minimum invasive implanting approach and easy-handling performance. Nevertheless, natural biomaterials-based injectable hydrogels with desirable nontoxicity are suffering from limited functions, failing to fulfill the requirements of clinical biomaterials. The development of novel injectable biomaterials with a combination of biocompatibility and adequate functional properties is a growing urgency toward biomedical applications. In this contribution, we report a simple and effective approach to fabricate multi-functional CMC-OSA-DTP hydrogels. Two kinds of natural polysaccharide derived polymers, carboxymethyl chitosan (CMC) and oxidized alginate (OSA) along with 3,3′-dithiopropionic acid dihydrazide (DTP) were utilized to introduce three dynamic covalent bonds. Owing to the existence of triple dynamic bonds, this unique CMC-OSA-DTP hydrogel possessed smart redox and pH stimuli-responsive property, injectability as well as self-healing ability. In addition, the CCK-8 and live/dead assays demonstrated satisfying cytocompatibility of the CMC-OSA-DTP hydrogel in vitro. Based on its attractive properties, this easy-fabricated and multi-functional hydrogel demonstrated the great potential as an injectable biomaterial in a variety of biomedical applications.

Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

2019 ◽  
Vol 7 (41) ◽  
pp. 6362-6369 ◽  
Author(s):  
Tomoki Nishimura ◽  
Naoki Sumi ◽  
Sada-atsu Mukai ◽  
Yoshihiro Sasaki ◽  
Kazunari Akiyoshi
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Self Healing ◽  
Injectable Hydrogels

An approach for the fabrication of self-healing injectable hydrogels based on the crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s is demonstrated.

Nanofibrous Substrate For Tissue Engineering Applications—A Review

2021 ◽  
Vol 8 (6) ◽  
pp. 13-21
Author(s):  
Odia Osemwegie ◽  
Lihua Lou ◽  
Ernest Smith ◽  
Seshadri Ramkumar
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Culture ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
High Volume ◽  
Clinical Applications ◽  
Critical Factors ◽  
Engineering Applications

Nanofiber substrates have been used for various biomedical applications, including tissue regeneration, drug delivery, and in-vitro cell culture. However, despite the high volume of studies in this field, current clinical applications remain minimal. Innovations for their applications continuously generate exciting prospects. In this review, we discuss some of these novel innovations and identify critical factors to consider before their adoption for biomedical applications.

scholarly journals Phenol–Hyaluronic Acid Conjugates: Correlation of Oxidative Crosslinking Pathway and Adhesiveness

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3130
Author(s):  
Jungwoo Kim ◽  
Sumin Kim ◽  
Donghee Son ◽  
Mikyung Shin
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Stability Limit ◽  
Polymeric Chain ◽  
Covalent Bonds ◽  
Adhesion Properties ◽  
Covalent Crosslinking ◽  
Natural Polysaccharide ◽  
Chemical Oxidants

Hyaluronic acid (HA) is a natural polysaccharide with great biocompatibility for a variety of biomedical applications, such as tissue scaffolds, dermal fillers, and drug-delivery carriers. Despite the medical impact of HA, its poor adhesiveness and short-term in vivo stability limit its therapeutic efficacy. To overcome these shortcomings, a versatile modification strategy for the HA backbone has been developed. This strategy involves tethering phenol moieties on HA to provide both robust adhesiveness and intermolecular cohesion and can be used for oxidative crosslinking of the polymeric chain. However, a lack of knowledge still exists regarding the interchangeable phenolic adhesion and cohesion depending on the type of oxidizing agent used. Here, we reveal the correlation between phenolic adhesion and cohesion upon gelation of two different HA–phenol conjugates, HA–tyramine and HA–catechol, depending on the oxidant. For covalent/non-covalent crosslinking of HA, oxidizing agents, horseradish peroxidase/hydrogen peroxide, chemical oxidants (e.g., base, sodium periodate), and metal ions, were utilized. As a result, HA–catechol showed stronger adhesion properties, whereas HA–tyramine showed higher cohesion properties. In addition, covalent bonds allowed better adhesion compared to that of non-covalent bonds. Our findings are promising for designing adhesive and mechanically robust biomaterials based on phenol chemistry.

Phenylboronic Acid-polymers for Biomedical Applications

2019 ◽  
Vol 26 (37) ◽  
pp. 6797-6816 ◽  
Author(s):  
Ji Hyun Ryu ◽  
Gyeong Jin Lee ◽  
Yu-Ru V. Shih ◽  
Tae-il Kim ◽  
Shyni Varghese
Keyword(s):  
Biomedical Applications ◽  
Phenylboronic Acid ◽  
Covalent Bond ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Dynamic Nature ◽  
Responsive Materials ◽  
Boronate Ester ◽  
Reversible Bonding ◽  
Reversible Covalent

Background: Phenylboronic acid-polymers (PBA-polymers) have attracted tremendous attention as potential stimuli-responsive materials with applications in drug-delivery depots, scaffolds for tissue engineering, HIV barriers, and biomolecule-detecting/sensing platforms. The unique aspect of PBA-polymers is their interactions with diols, which result in reversible, covalent bond formation. This very nature of reversible bonding between boronic acids and diols has been fundamental to their applications in the biomedical area. Methods: We have searched peer-reviewed articles including reviews from Scopus, PubMed, and Google Scholar with a focus on the 1) chemistry of PBA, 2) synthesis of PBA-polymers, and 3) their biomedical applications. Results: We have summarized approximately 179 papers in this review. Most of the applications described in this review are focused on the unique ability of PBA molecules to interact with diol molecules and the dynamic nature of the resulting boronate esters. The strong sensitivity of boronate ester groups towards the surrounding pH also makes these molecules stimuli-responsive. In addition, we also discuss how the re-arrangement of the dynamic boronate ester bonds renders PBA-based materials with other unique features such as self-healing and shear thinning. Conclusion: The presence of PBA in the polymer chain can render it with diverse functions/ relativities without changing their intrinsic properties. In this review, we discuss the development of PBA polymers with diverse functions and their biomedical applications with a specific focus on the dynamic nature of boronate ester groups.

Polygalacturonic acid hydrogel with short-chain hyaluronate cross-linker to prevent postoperative adhesion

2011 ◽  
Vol 26 (6) ◽  
pp. 552-564 ◽  
Author(s):  
Hsiu-Hui Peng ◽  
Jia-Wei Chen ◽  
Tzi-Peng Yang ◽  
Chung-Fan Kuo ◽  
Ying-Jing Wang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Clinical Applications ◽  
Short Chain ◽  
Postoperative Adhesion ◽  
Polygalacturonic Acid ◽  
Hydrogel Membrane ◽  
Cross Linker ◽  
Vitro Data ◽  
In Vitro Data

The purpose of this study was to develop a poly(galacturonic acid) (PGA)-based hydrogel using a short-chain hyaluronate (sHA) cross-linker for medical applications. PGA was grafted with adipic acid dihydrazide (ADH) to yield PGA–ADH, an amine-containing PGA derivative. This PGA–ADH formed a water-insoluble hydrogel by reacting with 1,1′-carbonyldiimidazole (CDI)–grafted sHA (sHA–CDI) in aqueous solution. The sHA–cross-linked PGA hydrogel has a water content of about 94%–97% and compressive modulus of 10.7–26.9 kPa. The in vitro data indicated that the sHA–cross-linked PGA hydrogel is degradable and noncytotoxic, thus suitable for biomedical applications. Animal implant studies showed that the sHA–cross-linked PGA hydrogel membrane exhibited antiadhesion potency, significantly higher than that found in untreated rats and has great potential for future clinical applications.

Influence of Strontium on In Vitro Bioactivity of Heat-Treated Porous Ca-P Ceramics on Titanium for Biomedical Applications

2011 ◽  
Vol 493-494 ◽  
pp. 453-457
Author(s):  
Kuan Chen Kung ◽  
Tzer Min Lee ◽  
Truan Sheng Lui
Keyword(s):  
Body Fluid ◽  
Biomedical Applications ◽  
Clinical Applications ◽  
Apatite Layer ◽  
X Ray Diffraction ◽  
Apatite Phase ◽  
X Ray ◽  
Heat Treated ◽  
Scanning Electron

The bioactivity of materials was evaluated based on the ability to induce a bond-like apatite layer on the surface in simulated body fluid (SBF). The aim of this study was to investigate the coatings containing strontium on bioactivity after heat treatment. After the materials were soaked in SBF for 1 day, precipitates did not form on the surface of heat-treated MAO coating without strontium. The precipitates were observed on surface of heat-treated MAO coatings containing strontium. After 7 days, the surface of heat-treated MAO coatings containing strontium was completely covered with precipitates. The precipitates were found to be composed of fiber structures using scanning electron microscope (SEM). The phase was identified as the apatite phase using thin film X-ray diffraction (TF-XRD). The results show that heat-treated MAO coatings containing strontium can induce the formation of an apatite layer on their surface. All finding in this study indicated that heat-treated MAO coatings containing strontium have good bioactivity for clinical applications.

Tannic acid-inspired, self-healing and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties

2021 ◽  
Author(s):  
Wen Shi ◽  
Yunfan Kong ◽  
Yajuan Su ◽  
Mitchell A. Kuss ◽  
Xiping Jiang ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Self Healing ◽  
Stimuli Responsive ◽  
Covalent Bonds

Due to their intrinsic injectable and self-healing characteristics, dynamic hydrogels, based on dynamic covalent bonds, have gained a great attention. In this study, a novel dynamic hydrogel based on the...

scholarly journals A Critical Review on Polymeric Biomaterials for Biomedical Applications

Polymers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 3015
Author(s):  
Cheirmadurai Kalirajan ◽  
Amey Dukle ◽  
Arputharaj Joseph Nathanael ◽  
Tae-Hwan Oh ◽  
Geetha Manivasagam
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Self Healing ◽  
Polymeric Biomaterials ◽  
Future Direction ◽  
Hard Tissue Engineering ◽  
In Vivo Effects ◽  
New Strategies

Natural and synthetic polymers have been explored for many years in the field of tissue engineering and regeneration. Researchers have developed many new strategies to design successful advanced polymeric biomaterials. In this review, we summarized the recent notable advancements in the preparation of smart polymeric biomaterials with self-healing and shape memory properties. We also discussed novel approaches used to develop different forms of polymeric biomaterials such as films, hydrogels and 3D printable biomaterials. In each part, the applications of the biomaterials in soft and hard tissue engineering with their in vitro and in vivo effects are underlined. The future direction of the polymeric biomaterials that could pave a path towards successful clinical implications is also underlined in this review.

Sign in / Sign up

Export Citation Format

Share Document