Tough, In-Situ Thermogelling, Injectable Hydrogels for Biomedical Applications

2015 ◽  
Vol 15 (4) ◽  
pp. 473-480 ◽  
Author(s):  
Ghulam Jalani ◽  
Derek H. Rosenzweig ◽  
Georges Makhoul ◽  
Sherif Abdalla ◽  
Renzo Cecere ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Injectable Hydrogels

scholarly journals Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications

2019 ◽  
Author(s):  
Amir Mellati ◽  
Javad Akhtari
Keyword(s):  
Extracellular Matrix ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Therapeutic Agent ◽  
Therapeutic Agents ◽  
Injectable Hydrogels ◽  
In Situ Gelling ◽  
Defect Filling ◽  
Injectable Gels

Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneous mixing with cells and therapeutic agents, minimally invasive administration, and perfect defect filling. In this review, we discuss various mechanisms which facilitate injectability of hydrogels, including in situ gelling liquids, injectable gels, and injectable particles. Then, we explore the biomedical applications of injectable hydrogels, including tissue engineering, therapeutic agent delivery, and medical devices.

Anodic synthesis of TiO2 nanotubes by step-up voltages

2021 ◽  
pp. 002199832110237
Author(s):  
V Sivaprakash ◽  
R Narayanan
Keyword(s):  
Corrosion Resistance ◽  
Tio2 Nanotubes ◽  
Biomedical Applications ◽  
Phase Changes ◽  
Electrochemical Anodization ◽  
Corrosion Resistant ◽  
Anodization Process ◽  
Anodic Synthesis ◽  
Input Potential

Fabrication of TiO2 nanotubes (NTs) has extensive application properties due to their high corrosion resistant and compatibility with biomedical applications, the synthesis of TiO2 nanotubes over titanium has drawn interest in various fields. The synthesis of TiO2 NTs using novel in-situ step-up voltage conditions in the electrochemical anodization process is recorded in this work. For manufacturing the NTs at 1 hour of anodization, the input potential of 30, 40 and 50 V was selected. With increasing step-up voltage during the anodization process, an improvement in the NTs was observed, favoring corrosion resistance properties. The surface of NTs enhances the structure of the ribs, raising the potential for feedback over time. XRD was used to analyze phase changes, and HR-SEM analyzed surface topography. Impedance tests found that longer NTs improved the corrosion resistance.

Injectable keratin hydrogels as hemostatic and wound dressing materials

2021 ◽  
Author(s):  
Ao Tang ◽  
Ying Li ◽  
Yiqian Yao ◽  
Xuexia Yang ◽  
Zhangjun Cao ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Biomedical Applications ◽  
Injectable Hydrogels ◽  
Good Biocompatibility ◽  
Dressing Materials ◽  
Administration Procedure ◽  
Wound Dressing Materials

Injectable hydrogels hold promise in biomedical applications due to their noninvasive administration procedure, and capacity enabling the filling of irregularly shaped defects. Protein-based hydrogels provide features including good biocompatibility and...

scholarly journals Fabrication of injectable hydrogels based on poly(l-glutamic acid) and chitosan

RSC Advances ◽  
2017 ◽  
Vol 7 (28) ◽  
pp. 17005-17019 ◽  
Author(s):  
Shifeng Yan ◽  
Taotao Wang ◽  
Xing Li ◽  
Yuhang Jian ◽  
Kunxi Zhang ◽  
...  
Keyword(s):  
Schiff Base ◽  
Glutamic Acid ◽  
Crosslinking Reaction ◽  
Injectable Hydrogels ◽  
Oppositely Charged

The in situ forming hydrogels based on oppositely charged poly(l-glutamic acid) (PLGA) and chitosan (CS) were prepared via a Schiff base crosslinking reaction.

scholarly journals Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

2021 ◽  
Vol 7 (23) ◽  
pp. eabe8739
Author(s):  
Xin Peng ◽  
Xianfeng Xia ◽  
Xiayi Xu ◽  
Xuefeng Yang ◽  
Boguang Yang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Gastric Perforation ◽  
Interfacial Water ◽  
Wet Adhesion ◽  
Tissue Interactions ◽  
Tissue Surface ◽  
Strong Adhesion ◽  
Surface Irregularities ◽  
Physical Interactions

Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications.

CLINICAL APPLICATIONS OF ELECTROCHEMOTHERAPY

2019 ◽  
Author(s):  
Gregor Serša
Keyword(s):  
Biomedical Applications ◽  
Liver Tumors ◽  
Checkpoint Inhibitors ◽  
Combined Treatment ◽  
Local Treatment ◽  
Industrial Applications ◽  
Interleukin 12 ◽  
Nice Guidelines ◽  
Or Gene

Electroporation has several biomedical and industrial applications. The biomedical applications are in the field of drug or gene delivery. Electrochemotherapy utilizes electroporation for the increased delivery of cytotoxic drugs like bleomycin or cisplatin into tumors. The use of electrochemotherapy has spread throughout Europe for the treatment of cutaneous tumors or metastases. It is in the NICE guidelines and is becoming standard ablative technique in treatment of cancer. The technological advancements have also enabled the use of electrochemotherapy for the treatment of deep seated tumors, such as soft tissue or liver tumors. Clinical studies demonstrate good effectiveness on fibrosarcomas, colorectal liver metastases and hepatocellular carcinoma. However, electrochemotherapy is a local treatment that also induces moderate local immune response. This so called “in situ vaccination” induced by electrochemotherapy can be exploited in combined treatment with immune checkpoint inhibitors or electrogene therapy with immunostimulating effect. Therefore, gene electrotransfer of plasmid coding for interleukin 12 (IL-12), in combination with electrochemotherapy could result in transformation of electrochemotherapy from local into systemic treatment. This is also of our current interest, and we are undertaking steps to bring this idea from preclinical into clinical testing.

3-D and electrically conducting functional skin mapping for biomedical applications

2018 ◽  
Vol 54 (8) ◽  
pp. 980-983 ◽  
Author(s):  
Xiaoxu Fu ◽  
Wenqiu Zeng ◽  
Ana C. Ramírez-Pérez ◽  
Grzegorz Lisak
Keyword(s):  
Conducting Polymer ◽  
Biomedical Applications ◽  
Human Subject ◽  
Ex Situ ◽  
Electrically Conducting

Ex situ and in situ 3-D and electrically conducting mapping of the skin topography via electropolymerization of a conducting polymer on a previously sampled skin stamp or directly on the skin of a live human subject were performed here with the intention to be further used in biomedical applications.

Preparation and Biomedical Application of Injectable Hydrogels

2021 ◽  
Author(s):  
Fengyuan Gao ◽  
Caicai Jiao ◽  
Bing Yu ◽  
Hailin Cong ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Biomedical Application ◽  
Injectable Hydrogels ◽  
Therapeutic Molecules

Injectable hydrogels are increasingly popular among researchers because of their in situ formability, in situ drug delivery, high targeting, and the ability to allow uniform incorporation of therapeutic molecules and/or...

Biodegradable poly(propylene) carbonate using in-situ generated CuNPs coated Tamarindus indica filler for biomedical applications

2019 ◽  
Vol 19 ◽  
pp. 106-113 ◽  
Author(s):  
M.P. Indira Devi ◽  
N. Nallamuthu ◽  
N. Rajini ◽  
T. Senthil Muthu Kumar ◽  
Suchart Siengchin ◽  
...  
Keyword(s):  
Propylene Carbonate ◽  
Biomedical Applications ◽  
Tamarindus Indica ◽  
Biodegradable Poly ◽  
Poly Propylene
Sign in / Sign up

Export Citation Format

Share Document