Selective Cell Adhesion and Biosensing Applications of Bio-Active Block Copolymers Prepared by CuAAC/Thiol-ene Double Click Reactions

2015 ◽  
Vol 15 (9) ◽  
pp. 1233-1241 ◽  
Author(s):  
Gizem Oyman Eyrilmez ◽  
Sean Doran ◽  
Eljesa Murtezi ◽  
Bilal Demir ◽  
Dilek Odaci Demirkol ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Block Copolymers ◽  
Click Reactions ◽  
Active Block

An easy way to the preparation of multi-miktoarm star block copolymers via sequential double click reactions

2010 ◽  
Vol 1 (5) ◽  
pp. 621 ◽  
Author(s):  
Aydan Dag ◽  
Hakan Durmaz ◽  
Volkan Kirmizi ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
Click Reactions ◽  
Miktoarm Star ◽  
Star Block Copolymers

scholarly journals Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers

2014 ◽  
Vol 1 (3) ◽  
pp. 134-153
Author(s):  
Omotunde Olubi ◽  
Laurisa London ◽  
Biswajit Sannigrahi ◽  
Peri Nagappan ◽  
Michael Williams ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Surface Active ◽  
Bioactive Surfaces ◽  
Active Block

Photocatalytically active block copolymer hybrid micelles from double hydrophilic block copolymers

2020 ◽  
Vol 140 ◽  
pp. 110037
Author(s):  
Afshin Nabiyan ◽  
Martin Schulz ◽  
Christof Neumann ◽  
Benjamin Dietzek ◽  
Andrey Turchanin ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Double Hydrophilic Block Copolymers ◽  
Active Block

scholarly journals In Vitro and In Vivo Studies of Biodegradability and Biocompatibility of Poly(εCL)-b-Poly(EtOEP)-Based Films

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3039
Author(s):  
Ilya Nifant’ev ◽  
Andrey Shlyakhtin ◽  
Pavel Komarov ◽  
Alexander Tavtorkin ◽  
Evgeniya Kananykhina ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Block Copolymers ◽  
Polymer Films ◽  
Hydrolytic Stability ◽  
Polymer Materials ◽  
In Vivo Studies ◽  
Cytotoxicity Test ◽  
The Impact

The control of surface bioadhesive properties of the subcutaneous implants is essential for the development of biosensors and controlled drug release devices. Poly(alkyl ethylene phosphate)-based (co)polymers are structurally versatile, biocompatible and biodegradable, and may be regarded as an alternative to poly(ethylene glycol) (PEG) copolymers in the creation of antiadhesive materials. The present work reports the synthesis of block copolymers of ε-caprolactone (εCL) and 2-ethoxy-1,3,2-dioxaphospholane-2-oxide (ethyl ethylene phosphate, EtOEP) with different content of EtOEP fragments, preparation of polymer films, and the results of the study of the impact of EtOEP/εCL ratio on the hydrophilicity (contact angle of wetting), hydrolytic stability, cytotoxicity, protein and cell adhesion, and cell proliferation using umbilical cord multipotent stem cells. It was found that the increase of EtOEP/εCL ratio results in increase of hydrophilicity of the polymer films with lowering of the protein and cell adhesion. MTT cytotoxicity test showed no significant deviations in toxicity of poly(εCL) and poly(εCL)-b-poly(EtOEP)-based films. The influence of the length of poly(EtOEP)chain in block-copolymers on fibrotic reactions was analyzed using subcutaneous implantation experiments (Wistar line rats), the increase of the width of the fibrous capsule correlated with higher EtOEP/εCL ratio. However, the copolymer-based film with highest content of polyphosphate had been subjected to faster degradation with a formation of developed contact surface of poly(εCL). The rate of the degradation of polyphosphate in vivo was significantly higher than the rate of the degradation of polyphosphate in vitro, which only confirms an objective value of in vivo experiments in the development of polymer materials for biomedical applications.

Water stable nanocoatings of poly(N-isopropylacrylamide)-based block copolymers on culture insert membranes for temperature-controlled cell adhesion

2020 ◽  
Vol 8 (34) ◽  
pp. 7812-7821 ◽  
Author(s):  
Masamichi Nakayama ◽  
Yuki Toyoshima ◽  
Hiroshi Chinen ◽  
Akihiko Kikuchi ◽  
Masayuki Yamato ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Block Copolymers ◽  
Spin Coating ◽  
Thermal Cell ◽  
Temperature Controlled

We report the facile and stable fabrication of thermoresponsive culture inserts by spin-coating poly(N-isopropylacrylamide)-based block copolymers for thermal cell adhesion/detachment control.

Cyclic homo and block copolymers through sequential double click reactions

2010 ◽  
Vol 48 (22) ◽  
pp. 5083-5091 ◽  
Author(s):  
Hakan Durmaz ◽  
Aydan Dag ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
Click Reactions

Modular Synthesis of Polyferrocenylsilane Block Copolymers by Cu-Catalyzed Alkyne/Azide “Click” Reactions

2013 ◽  
Vol 46 (4) ◽  
pp. 1296-1304 ◽  
Author(s):  
Meng Zhang ◽  
Paul A. Rupar ◽  
Chun Feng ◽  
Kaixiang Lin ◽  
David J. Lunn ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Click Reactions ◽  
Modular Synthesis
Sign in / Sign up

Export Citation Format

Share Document