Response surface design as a powerful tool for the development of environmentally benign HPLC methods for the determination of two antihypertensive combinations: Greenness assessment by two green analytical chemistry evaluation tools

2018 ◽  
Vol 41 (16) ◽  
pp. 3213-3223 ◽  
Author(s):  
Ahmed Hemdan ◽  
Ragaa Magdy ◽  
Maha Farouk
Keyword(s):  
Analytical Chemistry ◽  
Response Surface ◽  
Environmentally Benign ◽  
Green Analytical Chemistry ◽  
Response Surface Design ◽  
Evaluation Tools ◽  
Surface Design

Defluoridation of drinking water by magnesium and aluminum electrocoagulation in continuous flow-rate: A response surface design.

2021 ◽  
pp. 1-37
Author(s):  
Ana Gabriela Sierra-Sánchez ◽  
Verónica Martínez-Miranda ◽  
Elia Alejandra Teutli-Sequeira ◽  
Ivonne Linares-Hernández ◽  
Guadalupe Vázquez-Mejía ◽  
...  
Keyword(s):  
Drinking Water ◽  
Response Surface ◽  
Flow Rate ◽  
Continuous Flow ◽  
Response Surface Design ◽  
Surface Design

scholarly journals NEW, GREEN AND MINIATURIZED ANALYTICAL METHOD FOR DETERMINATION OF CEFADROXIL MONOHYDRATE IN CAPSULES

2019 ◽  
Vol 3 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Bianca Marco ◽  
Ana Kogawa ◽  
Hérida Salgado
Keyword(s):  
Analytical Chemistry ◽  
Standard Sample ◽  
Low Cost ◽  
Visible Region ◽  
Hplc Method ◽  
Minimal Amount ◽  
Green Analytical Chemistry ◽  
Color Reagent ◽  
Routine Quality Control

Cefadroxil, an oral antimicrobial, presents few techniques optimized for the reduction of solvents and toxic residues and/or non-use of them. So, a quantitative, new and miniaturized method for determination of cefadroxil monohydrate in capsules has been developed and validated by spectrophotometric method in the visible region according to the international guidelines. The analyzes were performed using microplates containing 96 wells, 1 % of phenolphthalein and sodium hydroxide 0.1 M as reagent at 552 nm. The method was (i) linear in the range of 15-115 µg mL-1, (ii) selective when comparing standard, sample, adjuvants and color reagent, (iii) precise with deviations below 4 %, (iv) accurate when comparing the proposed method with the HPLC method, (v) robusts by making small and deliberate modifications to the method, (vi) besides being fast, low cost, eco-friendly and generates minimal amount of waste. The method can be applied to the routine quality control of cefadroxil monohydrate in capsules and an effective and accessible alternative that contemplates the concepts of current and sustainable green analytical chemistry.

Cleaning and Bacteria Removal in Milking Systems by Alkaline Electrolyzed Oxidizing Water with Response Surface Design

2019 ◽  
Vol 62 (5) ◽  
pp. 1251-1258 ◽  
Author(s):  
Yu Liu ◽  
Chaoyuan Wang ◽  
Zhengxiang Shi ◽  
Baoming Li
Keyword(s):  
Water Treatment ◽  
Response Surface ◽  
Treatment Time ◽  
System Response ◽  
Surface Model ◽  
Response Surface Design ◽  
Surface Design ◽  
Response Surface Models ◽  
Surface Models ◽  
Bacteria Removal

Abstract. A wash cycle using an alkaline solution with a dissolved chemical detergent is a standard clean-in-place (CIP) process for cleaning milking systems. However, long-term chemical use may corrode equipment and create difficulties in wastewater treatment. This study investigated the potential for using alkaline electrolyzed oxidizing (EO) water as an alternative to alkaline chemical detergent for removal of microorganisms and adenosine triphosphate (ATP) on milking system materials. Laboratory trials were performed based on a Box-Behnken response surface design to assess the cleaning effect of alkaline EO water on three materials typically used in milking systems: stainless steel, rubber gasket, and polyvinyl chloride (PVC) hose. Results showed that alkaline EO water treatment was generally enhanced with increased treatment time, temperature, and pH, and their interaction effects were also observed in ATP removal. However, treatment time did not have a dominant role in cleaning PVC hose. Response surface models were developed to reliably predict detected microorganisms and relative light units (RLU) on the three materials after alkaline EO water treatment. Based on the response surface models, the three parameters for alkaline EO water cleaning were optimized as treatment time of 10.0 min, temperature of 61.8°C, and pH of 12, after which microorganisms and RLU were nearly undetectable. Alkaline EO water treatment with the optimized parameters had an equivalent or better cleaning ability compared to the commercial detergent, suggesting its potential as a cleaning and bacteria removal agent for milking systems. Keywords: Alkaline electrolyzed oxidizing water, Cleanliness, Milking system, Response surface model.

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