Comments on “The Ulcerogenic Potential of Copper Aspirinate Seems to be More Imaginary than Real”

1985 ◽  
Vol 74 (6) ◽  
pp. 700 ◽  
Author(s):  
Geoffrey B. West
Keyword(s):  
Copper Aspirinate

scholarly journals Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils

2002 ◽  
Vol 8 (5) ◽  
pp. 253-256 ◽  
Author(s):  
Ling Li ◽  
Zhiqiang Shen ◽  
Weimin Yang ◽  
Wanling Wu ◽  
Weiping Liu ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Lipid Peroxide ◽  
Superoxide Dismutase Activity ◽  
Global Cerebral Ischemia ◽  
Peroxide Content ◽  
Copper Aspirinate

The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg−1 ) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.

Gastric mucosal damage due to aspirin and copper aspirinate assessed by gastric mucosal potential difference changes

1992 ◽  
Vol 27 (4) ◽  
pp. 245-250 ◽  
Author(s):  
A.A. Alich ◽  
L.E. Wittmers ◽  
Lee A. Anderson ◽  
Elise M. Rieschl ◽  
Patricia L. Peterson
Keyword(s):  
Mucosal Damage ◽  
Potential Difference ◽  
Gastric Mucosal Damage ◽  
Copper Aspirinate

Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat

1983 ◽  
Vol 72 (12) ◽  
pp. 1457-1461 ◽  
Author(s):  
Agnes A. Alich ◽  
Victoria J. Welsh ◽  
Lorentz E. Wittmers
Keyword(s):  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Copper Aspirinate

scholarly journals Inhibitory Effects of Dimeric Copper(II) bis(o-acetoxybenzoate) on Platelet-neutrophil adhesion and Thrombosis

2001 ◽  
Vol 8 (2) ◽  
pp. 103-105
Author(s):  
Zhiqiang Shen ◽  
Lanou Wu ◽  
Weiping Liu ◽  
Jikai Liu ◽  
Zhihhe Chen
Keyword(s):  
Arachidonic Acid ◽  
Venous Thrombosis ◽  
Neutrophil Adhesion ◽  
Inhibitory Effects ◽  
Antithrombotic Effect ◽  
Antithrombotic Activity ◽  
Activated Platelets ◽  
Copper Aspirinate

Antithrombotic effect of the copper-aspirin complex (dimeric copper(II) bis(o-acetoxybenzoate) was evaluated in the model of venous thrombosis; its effects on platelet-neutrophil adhesion were investigated by use of rosette assay. The results showed that the intragastrically administered copper-aspirin complex (5, 7, and 10 mg kg−1) dose-dependently lowered the wet and dry thrombus weight; it significantly decreased the binding of arachidonic acid-activated platelets to neutrophils with an IC50 value of 41.5 μmol L-1. The results suggested that copper aspirinate inhibited platelet-neutrophil adhesion and resulted in a more potent antithrombotic activity.

Total serum copper and ceruloplasmin levels following administration of copper aspirinate to rats and guinea-pigs

1980 ◽  
Vol 10 (5) ◽  
pp. 465-470 ◽  
Author(s):  
D. H. Brown ◽  
J. Dunlop ◽  
W. E. Smith ◽  
J. Teape ◽  
A. J. Lewis
Keyword(s):  
Guinea Pigs ◽  
Serum Copper ◽  
Total Serum ◽  
Copper Aspirinate

Preliminary chronic toxicity study of copper aspirinate

1984 ◽  
Vol 91 (2) ◽  
pp. L31-L34 ◽  
Author(s):  
John R.J. Sorenson ◽  
Thomas M. Rolniak ◽  
Louis W. Chang
Keyword(s):  
Chronic Toxicity ◽  
Toxicity Study ◽  
Copper Aspirinate

scholarly journals Distribution of Copper in Rats Submitted to Treatment With Copper Aspirinate

1998 ◽  
Vol 5 (6) ◽  
pp. 333-335
Author(s):  
Weiping Liu ◽  
Yikun Yang ◽  
Huizhou Xiong ◽  
Ying Lu ◽  
Rong Yang
Keyword(s):  
Oral Administration ◽  
Metal Content ◽  
Sprague Dawley ◽  
Blood Brain ◽  
Sprague Dawley Rats ◽  
Copper Aspirinate ◽  
Kidney Liver

The distribution of copper in Sprague – Dawley rats following a three month oral administration of 0,10 or 50mg/kg copper aspirinate has been investigated. Metal content was determined by ICP – AES in blood, brain, kidney, liver, lung, spleen, and dejection. The results show that treatment with copper aspirinate did not cause accumulation of copper in rats and excess ingested copper was excreted through feces.

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