scholarly journals Distribution of Copper in Rats Submitted to Treatment With Copper Aspirinate

1998 ◽  
Vol 5 (6) ◽  
pp. 333-335
Author(s):  
Weiping Liu ◽  
Yikun Yang ◽  
Huizhou Xiong ◽  
Ying Lu ◽  
Rong Yang
Keyword(s):  
Oral Administration ◽  
Metal Content ◽  
Sprague Dawley ◽  
Blood Brain ◽  
Sprague Dawley Rats ◽  
Copper Aspirinate ◽  
Kidney Liver

The distribution of copper in Sprague – Dawley rats following a three month oral administration of 0,10 or 50mg/kg copper aspirinate has been investigated. Metal content was determined by ICP – AES in blood, brain, kidney, liver, lung, spleen, and dejection. The results show that treatment with copper aspirinate did not cause accumulation of copper in rats and excess ingested copper was excreted through feces.

Serum metabolomic signatures of Sprague-Dawley rats after oral administration of titanium dioxide nanoparticles

NanoImpact ◽  
2020 ◽  
Vol 19 ◽  
pp. 100236
Author(s):  
Zhangjian Chen ◽  
Shuo Han ◽  
Di Zhou ◽  
Pai Zheng ◽  
Shupei Zhou ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Oral Administration ◽  
Titanium Dioxide Nanoparticles ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application

Xenobiotica ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 169-181 ◽  
Author(s):  
James M. Mathews ◽  
Sherri S. Brown ◽  
Purvi R. Patel ◽  
Sherry R. Black ◽  
Troy T. Banks ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats ◽  
Dermal Application

Permeability of blood-brain barrier to various sized molecules

1985 ◽  
Vol 248 (5) ◽  
pp. H712-H718 ◽  
Author(s):  
W. G. Mayhan ◽  
D. D. Heistad
Keyword(s):  
Blood Brain Barrier ◽  
Fluorescent Microscopy ◽  
Brain Barrier ◽  
Sprague Dawley ◽  
Acute Hypertension ◽  
Size Dependent ◽  
Blood Brain ◽  
Sprague Dawley Rats ◽  
Intravital Fluorescent Microscopy ◽  
Dextran Clearance

We studied disruption of the blood-brain barrier (BBB) by acute hypertension and a hyperosmolar solution. The goals were to determine whether 1) disruption of the BBB occurs primarily in arteries, capillaries, or veins, and 2) transport of different-sized molecules is homogeneous or size dependent. Sprague-Dawley rats were studied using intravital fluorescent microscopy of pial vessels and fluorescein-labeled dextrans (FITC-dextran, mol wt = 70,000, 20,000, and 4,000 daltons). The site of disruption was determined by the appearance of microvascular leaky sites. Transport of different-sized molecules was calculated from clearance of FITC-dextran. During gradual hypertension and osmotic disruption, all leaky sites were venular. Rapid hypertension produced venular leaky sites and, in some experiments, diffuse arteriolar extravasation of FITC-dextran. Clearance of different-sized molecules was homogeneous during acute hypertension. In contrast, clearance of molecules during osmotic disruption was size dependent. The findings suggest that 1) venules and veins are the primary sites of disruption following acute hypertension and a hyperosmolar solution; 2) transport of different-sized molecules is homogeneous following acute hypertension, which suggests a vesicular mechanism; and 3) transport following hyperosmolar disruption is size dependent, which suggests that hyperosmolar disruption may involve formation of pores as well as vesicular transport.

scholarly journals Absorption, Distribution, Excretion, and Pharmacokinetics ofC-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Sang Hyun Park ◽  
Kannampalli Pradeep
Keyword(s):  
Clinical Trials ◽  
Small Intestine ◽  
Oral Administration ◽  
Female Rats ◽  
Sprague Dawley ◽  
Male And Female ◽  
Phase Ii Clinical Trials ◽  
Male And Female Rats ◽  
Sprague Dawley Rats ◽  
Peak Value

The main objective of this investigation was to determine the absorption, distribution, excretion, and pharmacokinetics of the antimalarial drug pyronaridine tetraphosphate (PNDP) in Sprague-Dawley rats. Following oral administration of a single dose (10 mg/Kg) ofC-PNDP, it was observed that the drug was readily absorbed from the small intestine within 1 hour following oral administration and was widely distributed in most of the tissues investigated as determined from the observed radioactivity in the tissues. The peak value of the drug in the blood was reached at around 8 hours postadministration, and radioactivity was detected in most of the tissues from 4 hours onwards.C-PNDP showed a poor permeability across the blood-brain barrier, and the absorption, distribution, and excretion ofC-PNDP were found to be gender-independent as both male and female rats showed a similar pattern of radioactivity. Excretion of the drug was predominantly through the urine with a peak excretion post 24 hours of administration. A small amount of the drug was also excreted in the feces and also in the breath. It was found that theCmax, AUC (0-inf), andTmaxvalues were similar to those observed in the Phase II clinical trials of pyronaridine/artesunate (Pyramax) conducted in Uganda.

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