Fragmentation of the main triterpene acids of apple by LC-APCI-MSn

2018 ◽  
Vol 53 (9) ◽  
pp. 882-892 ◽  
Author(s):  
Stefania Sut ◽  
Gabriele Poloniato ◽  
Mario Malagoli ◽  
Stefano Dall'Acqua
Keyword(s):  
Triterpene Acids ◽  
Main Triterpene

scholarly journals Triterpene Acid and Phenolics from Ancient Apples of Friuli Venezia Giulia as Nutraceutical Ingredients: LC-MS Study and In Vitro Activities

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1109 ◽  
Author(s):  
Stefania Sut ◽  
Gokhan Zengin ◽  
Filippo Maggi ◽  
Mario Malagoli ◽  
Stefano Dall’Acqua
Keyword(s):  
Radical Scavenging ◽  
Reducing Power ◽  
Total Phenolic ◽  
Inhibitory Effects ◽  
Triterpene Acid ◽  
Beneficial Effects ◽  
Triterpene Acids ◽  
Phenolic Constituents ◽  
Friuli Venezia Giulia

Triterpene acid and phenolic constituents from nine ancient varieties of apple (Malus domestica) fruits cultivated in Fanna, Friuli Venezia Giulia region, northeast Italy, were analyzed and compared with four commercial apples (‘Golden Delicious’, ‘Red Delicious’, ‘Granny Smith’ and ‘Royal Gala’). Total phenolic and flavonoid contents were measured by spectrophotometric assays. The quali-quantitative fingerprint of secondary metabolites including triterpene acid was obtained by LC-DAD-(ESI)-MS and LC-(APCI)-MS, respectively. Based on the two LC-MS datasets, multivariate analysis was used to compare the composition of ancient fruit varieties with those of four commercial apples. Significant differences related mainly to the pattern of triterpene acids were found. Pomolic, euscaphyc, maslinic and ursolic acids are the most abundant triterpene in ancient varieties pulps and peels, while ursolic and oleanolic acids were prevalent in the commercial fruits. Also, the content of the phenolic compounds phloretin-2-O-xyloglucoside and quercetin-3-O-arabinoside was greater in ancient apple varieties. The antioxidant (radical scavenging, reducing power, metal chelating and phosphomolybdenum assays) and enzyme inhibitory effects (against cholinesterase, tyrosinase, amylase and glucosidase) of the samples were investigated in vitro. Antioxidant assays showed that the peels were more active than pulps. However, all the samples exhibited similar enzyme inhibitory effects. Ancient Friuli Venezia Giulia apple cultivars can be a source of chlorogenic acid and various triterpene acids, which are known for their potential anti-inflammatory activity and beneficial effects on lipid and glucose metabolism. Our results make these ancient varieties suitable for the development of new nutraceutical ingredients.

scholarly journals A Natural Combination Extract of Viscum album L. Containing Both Triterpene Acids and Lectins Is Highly Effective against AML In Vivo

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0133892 ◽  
Author(s):  
Catharina I. Delebinski ◽  
Monika Twardziok ◽  
Susann Kleinsimon ◽  
Florian Hoff ◽  
Katharina Mulsow ◽  
...  
Keyword(s):  
Viscum Album ◽  
Triterpene Acids ◽  
Highly Effective ◽  
Natural Combination

Triterpenes induced by young apple fruits in response to herbivore attack

2021 ◽  
Author(s):  
Yuto Ohata ◽  
Yuuki Tetsumoto ◽  
Sayo Morita ◽  
Naoki Mori ◽  
Yoichi Ishiguri ◽  
...  
Keyword(s):  
Malus Domestica ◽  
Spodoptera Litura ◽  
Mechanical Damage ◽  
Antifeedant Activity ◽  
Varietal Differences ◽  
Triterpene Acids ◽  
Lepidopteran Insect ◽  
Pest Insects ◽  
Herbivore Attack ◽  
Apple Fruits

Abstract Apples Malus domestica, known as a rich source of triterpene acids, induced more variety and quantity of triterpene acids in response to herbivory or mechanical damage. There were three major induced compounds: pomaceic acid and euscaphic acid, both of which are known apple triterpene acids, and 2α,19α-dihydroxy-3-oxours-12-en-28-oic acid (named eriobotoric acid), which was first identified in apples. In this study, the three compounds’ induction curves after damage, varietal differences in induction amounts, and physiological roles against pest insects were further investigated. Eriobotoric acid showed clear antifeedant activity against lepidopteran insect Spodoptera litura but not against apple pests.

scholarly journals Synthesis and Evaluation of Anticancer Activities of Novel C-28 Guanidine-Functionalized Triterpene Acid Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 3000 ◽  
Author(s):  
Anna Spivak ◽  
Rezeda Khalitova ◽  
Darya Nedopekina ◽  
Lilya Dzhemileva ◽  
Milyausha Yunusbaeva ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Human Tumor ◽  
Jurkat Cells ◽  
Anticancer Activities ◽  
Triterpene Acid ◽  
Guanidine Group ◽  
Triterpene Acids ◽  
Cycle Arrest ◽  
Normal Human ◽  
Derivatives Of

Triterpene acids, namely, 20,29-dihydrobetulinic acid (BA), ursolic acid (UA) and oleanolic acid (OA) were converted into C-28-amino-functionalized triterpenoids 4–7, 8a, 15, 18 and 20. These compounds served as precursors for the synthesis of novel guanidine-functionalized triterpene acid derivatives 9b–12b, 15c, 18c and 20c. The influence of the guanidine group on the antitumor properties of triterpenoids was investigated. The cytotoxicity was tested on five human tumor cell lines (Jurkat, K562, U937, HEK, and Hela), and compared with the tests on normal human fibroblasts. The antitumor activities of the most tested guanidine derivatives was lower, than that of corresponding amines, but triterpenoids with the guanidine group were less toxic towards human fibroblasts. The introduction of the tris(hydroxymethyl)aminomethane moiety into the molecules of triterpene acids markedly enhanced the cytotoxic activity of the resulting conjugates 15, 15c, 18b,c and 20b,c irrespective of the triterpene skeleton type. The dihydrobetulinic acid amine 15, its guanidinium derivative 15c and guanidinium derivatives of ursolic and oleanolic acids 18c and 20c were selected for extended biological investigations in Jurkat cells, which demonstrated that the antitumor activity of these compounds is mediated by induction of cell cycle arrest at the S-phase and apoptosis.

scholarly journals Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2Synthase-1

2014 ◽  
Vol 77 (6) ◽  
pp. 1445-1451 ◽  
Author(s):  
Moritz Verhoff ◽  
Stefanie Seitz ◽  
Michael Paul ◽  
Stefan M. Noha ◽  
Johann Jauch ◽  
...  
Keyword(s):  
Pentacyclic Triterpene ◽  
Triterpene Acids ◽  
Anti Inflammatory

Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids

1994 ◽  
Vol 120 (9) ◽  
pp. 513-518 ◽  
Author(s):  
Ho-Young Lee ◽  
Hae-Young Chung ◽  
Ki-Heun Kim ◽  
Jung-Joon Lee ◽  
Kyu-Won Kim
Keyword(s):  
Stem Cells ◽  
Triterpene Acids ◽  
Induction Of Differentiation ◽  
F9 Teratocarcinoma

Structure of psolusoside a ? The main triterpene glycoside from the holothurianPsolus fabricii

1985 ◽  
Vol 21 (2) ◽  
pp. 197-202 ◽  
Author(s):  
V. I. Kalinin ◽  
A. I. Kalinovskii ◽  
V. A. Stonik
Keyword(s):  
Triterpene Glycoside ◽  
Main Triterpene

Triterpene Acids from Euscaphis japonica and Assessment of Their Cytotoxic and Anti-NO Activities

Planta Medica ◽  
2012 ◽  
Vol 78 (14) ◽  
pp. 1584-1590 ◽  
Author(s):  
Li-Jie Zhang ◽  
Jing-Jy Cheng ◽  
Chia-Ching Liao ◽  
Hui-Ling Cheng ◽  
Hung-Tse Huang ◽  
...  
Keyword(s):  
Triterpene Acids
Sign in / Sign up

Export Citation Format

Share Document