scholarly journals Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E2Synthase-1

2014 ◽  
Vol 77 (6) ◽  
pp. 1445-1451 ◽  
Author(s):  
Moritz Verhoff ◽  
Stefanie Seitz ◽  
Michael Paul ◽  
Stefan M. Noha ◽  
Johann Jauch ◽  
...  
Keyword(s):  
Pentacyclic Triterpene ◽  
Triterpene Acids ◽  
Anti Inflammatory

Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae

2006 ◽  
Vol 14 (16) ◽  
pp. 5673-5677 ◽  
Author(s):  
María C. Aguirre ◽  
Carla Delporte ◽  
Nadine Backhouse ◽  
Silvia Erazo ◽  
María Eugenia Letelier ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Pentacyclic Triterpene ◽  
Triterpene Acids ◽  
Anti Inflammatory ◽  
Ugni Molinae

Triterpene Acids from the Leaves ofPerilla frutescensand Their Anti-inflammatory and Antitumor-promoting Effects

2004 ◽  
Vol 68 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Norihiro BANNO ◽  
Toshihiro AKIHISA ◽  
Harukuni TOKUDA ◽  
Ken YASUKAWA ◽  
Hiroshi HIGASHIHARA ◽  
...  
Keyword(s):  
Triterpene Acids ◽  
Anti Inflammatory

Studies on biliary excretion in the rabbit - II. The relationship between the chemical structure of certain natural or synthetic pentacyclic triterpenes and their icterogenic activity - Part 2: The substituents on carbon atoms 17, 19, 20 and 22

1964 ◽  
Vol 160 (979) ◽  
pp. 246-257 ◽  
Keyword(s):  
Chemical Structure ◽  
Hydroxyl Group ◽  
Side Chain ◽  
Fatty Acid Residue ◽  
Structural Variations ◽  
Modified Technique ◽  
Considerable Decrease ◽  
Pentacyclic Triterpene ◽  
Triterpene Acids ◽  
The Relationship

Previously reported work in this series (Brown, Rimington & Sawyer 1963) produced evidence that icterogenic activity (i.a.) of the pentacyclic triterpene acids is based upon the presence of a β-equatorially orientated hydroxyl group at C (3), or a hydroxyl at C (24), and a 22β-angeloyloxy side chain in the molecule of the particular active compound. The second part of this work, dealing with certain structural variations in triterpenes of the oleanane, 24-noroleanane (hedragane) and ursane series, is reported in this paper. These variations involve i.a. esterification of the C (28) carboxyl, saturation of the 22β-angeloyl side chain or replacement of this by simple saturated aliphatic acids. Assays are recorded of a further thirteen of these compounds for icterogenic activity using the modified technique described in the second paper of this series (Brown et al . 1963). It has been concluded from this work that the icterogenicity of 3β- or 24β-hydroxy triterpene acids is undoubtedly associated with the 22β-angeloyloxy side chain. Removal of the esterifying group at C (22) or its replacement by a simple saturated fatty acid residue is followed by complete loss of activity. Esterification of the C (28) carboxyl produces a considerable decrease in icterogenic potency due, probably, to a decrease in solubility of the compound.

Characterization of anti-inflammatory triterpene acids from rose hip powder (Rosa canina L.)

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
L Saaby ◽  
A Jäger ◽  
L Moesby ◽  
E Hansen ◽  
S Christensen
Keyword(s):  
Rosa Canina ◽  
Triterpene Acids ◽  
Rose Hip ◽  
Anti Inflammatory

scholarly journals Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride

2019 ◽  
Vol 20 (11) ◽  
pp. 2828 ◽  
Author(s):  
Ioana Zinuca Pavel ◽  
Rene Csuk ◽  
Corina Danciu ◽  
Stefana Avram ◽  
Flavia Baderca ◽  
...  
Keyword(s):  
Zinc Chloride ◽  
Structural Changes ◽  
Biological Activities ◽  
Antitumor Effects ◽  
Pentacyclic Triterpene ◽  
Good Tolerability ◽  
Maslinic Acid ◽  
Dermal Thickness ◽  
Anti Inflammatory

Maslinic acid is a pentacyclic triterpene with a plethora of biological activities, including anti-inflammatory, antioxidant, antimicrobial, cardioprotective, and antitumor effects. New derivatives with improved properties and broad-spectrum activity can be obtained following structural changes of the compound. The present study was aimed to characterize a benzylamide derivative of maslinic acid—benzyl (2α, 3β) 2,3-diacetoxy-olean−12-en-28-amide (EM2)—with respect to the anti-angiogenic and anti-inflammatory effects in two in vivo experimental models. Consequently, the compound showed good tolerability and lack of irritation in the chorioallantoic membrane assay with no impairment of the normal angiogenic process during the tested stages of development. In the acute ear inflammation murine model, application of EM2 induced a mild anti-inflammatory effect that was potentiated by the association with zinc chloride (ZnCl2). A decrease in dermal thickness of mice ears was observed when EM2 and ZnCl2 were applied separately or in combination. Moreover, hyalinization of the dermis appeared only when EM2 was associated with ZnCl2, strongly suggesting the role of their combination in wound healing.

scholarly journals Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Shyh-Shyun Huang ◽  
Chuan-Sung Chiu ◽  
Hsien-Jung Chen ◽  
Wen-Chi Hou ◽  
Ming-Jyh Sheu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Interleukin 1 ◽  
Late Phase ◽  
Centella Asiatica ◽  
Neutrophil Infiltration ◽  
Asiatic Acid ◽  
Pentacyclic Triterpene ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Oxide Synthase

Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plantCentella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test, AA decreased the paw edema at the 4th and 5th h afterλ-carrageenan (Carr) administration and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue. AA decreased the nitric oxide (NO), tumor necrosis factor-α(TNF-α), and interleukin-1β(IL-1β) levels on serum level at the 5th h after Carr injection. Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and nuclear factor-κB (NF-κB) expressions at the 5th h in the edema paw. An intraperitoneal (i.p.) injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin (Indo). The anti-inflammatory mechanisms of AA might be related to the decrease in the level of MDA, iNOS, COX-2, and NF-κB in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver.

Anti-Inflammatory and Anti-Tumor-Promoting Effects of Triterpene Acids and Sterols from the FungusGanoderma lucidum

2007 ◽  
Vol 4 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Toshihiro Akihisa ◽  
Yuji Nakamura ◽  
Masaaki Tagata ◽  
Harukuni Tokuda ◽  
Ken Yasukawa ◽  
...  
Keyword(s):  
Triterpene Acids ◽  
Anti Inflammatory
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