Retinoic acid-induced AP-1 transcriptional activity regulates B16 mouse melanoma growth inhibition and differentiation

2003 ◽  
Vol 194 (2) ◽  
pp. 162-170 ◽  
Author(s):  
Ying Huang ◽  
Goran Boskovic ◽  
Richard M. Niles
Keyword(s):  
Retinoic Acid ◽  
Growth Inhibition ◽  
Transcriptional Activity ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma ◽  
Melanoma Growth

Retinoic Acid Specifically Increases Nuclear PKCα and Stimulates AP-1 Transcriptional Activity in B16 Mouse Melanoma Cells

1995 ◽  
Vol 221 (2) ◽  
pp. 377-384 ◽  
Author(s):  
Joachim R. Gruber ◽  
Sejal Desai ◽  
Jan Krzysztof Blusztajn ◽  
Richard M. Niles
Keyword(s):  
Retinoic Acid ◽  
Transcriptional Activity ◽  
Melanoma Cells ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma

Expression and transcriptional activity of Ap-1, CRE, and URE binding proteins in B16 mouse melanoma subclones

1994 ◽  
Vol 10 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Susan E. Rutberg ◽  
Ira M. Goldstein ◽  
Yang M. Yang ◽  
Christopher W. Stackpole ◽  
Zeev Ronai
Keyword(s):  
Transcriptional Activity ◽  
Binding Proteins ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma

scholarly journals Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy

2009 ◽  
Vol 2009 ◽  
pp. 1-13 ◽  
Author(s):  
Tomoaki Takada ◽  
Toshiharu Yamashita ◽  
Makito Sato ◽  
Akiko Sato ◽  
Ichiro Ono ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Magnetite Nanoparticles ◽  
Transplanted Tumor ◽  
Therapeutic Protocol ◽  
Therapy Strategy ◽  
Exposure Temperature ◽  
B16 Mouse Melanoma ◽  
The Impact ◽  
Melanoma Growth ◽  
Significant Growth Inhibition

Melanogenesis substrate, N-propionyl-cysteaminylphenol (NPrCAP), is selectively incorporated into melanoma cells and inhibits their growth by producing cytotoxic free radicals. Magnetite nanoparticles also disintegrate cancer cells and generate heat shock protein (HSP) upon exposure to an alternating magnetic field (AMF). This study tested if a chemo-thermo-immunotherapy (CTI therapy) strategy can be developed for better management of melanoma by conjugating NPrCAP on the surface of magnetite nanoparticles (NPrCAP/M). We examined the feasibility of this approach in B16 mouse melanoma and evaluated the impact of exposure temperature, frequency, and interval on the inhibition of re-challenged melanoma growth. The therapeutic protocol against the primary transplanted tumor with or without AMF exposure once a day every other day for a total of three treatments not only inhibited the growth of the primary transplant but also prevented the growth of the secondary, re-challenge transplant. The heat-generated therapeutic effect was more significant at a temperature of43∘C than either41∘C or46∘C. NPrCAP/M with AMF exposure, instead of control magnetite alone or without AMF exposure, resulted in the most significant growth inhibition of the re-challenge tumor and increased the life span of the mice. HSP70 production was greatest at43∘C compared to that with41∘C or46∘C. CD+T cells were infiltrated at the site of the re-challenge melanoma transplant.

Growth inhibition and induction of phenotypic alterations by l-histidinol in B16 mouse melanoma cells

1989 ◽  
Vol 47 (3) ◽  
pp. 193-197 ◽  
Author(s):  
J. Nordenberg ◽  
L. Wasserman ◽  
H. Gutman ◽  
E. Beery ◽  
A. Novogrodsky
Keyword(s):  
Growth Inhibition ◽  
Melanoma Cells ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma
Sign in / Sign up

Export Citation Format

Share Document