Expression and transcriptional activity of Ap-1, CRE, and URE binding proteins in B16 mouse melanoma subclones

1994 ◽  
Vol 10 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Susan E. Rutberg ◽  
Ira M. Goldstein ◽  
Yang M. Yang ◽  
Christopher W. Stackpole ◽  
Zeev Ronai
1995 ◽  
Vol 221 (2) ◽  
pp. 377-384 ◽  
Author(s):  
Joachim R. Gruber ◽  
Sejal Desai ◽  
Jan Krzysztof Blusztajn ◽  
Richard M. Niles

2007 ◽  
Vol 17 (1) ◽  
pp. 17-30 ◽  
Author(s):  
Matthias Oppitz ◽  
Christian Busch ◽  
Gernot Schriek ◽  
Marco Metzger ◽  
Lothar Just ◽  
...  

1978 ◽  
Vol 65 (1) ◽  
pp. 73-83 ◽  
Author(s):  
V. Sheik Fareed ◽  
V.P. Bhavanandan ◽  
E.A. Davidson

2017 ◽  
Author(s):  
Dahong Wang ◽  
Lanlan Wei ◽  
Shuaiying Zhang

The biological activities of quinoxalone, a novel small molecular substance isolated from the broth of the myxobacterium Stigmatella eracta WXNXJ-B, was investigated. This study was designed to determine the anti-proliferative, apoptotic property of quinoxalone, using B16 mouse melanoma cells as a model system. The results showed that quinoxalone has antitumor activity and can significantly inhibit the proliferation of B16 cells. The extent and the timing of apoptosis were strongly dependent on the dose. After treating with quinoxalone and staining with Hoechst 33342, B16 cells showed typical apoptotic morphological features such as chromatin condensation by fluorescent microscopy. DNA isolated from B16 cells cultured with quinoxalone showed a typical DNA ladder of apoptosis in agarose gel electrophoresis. Further investigation results showed that the apoptotic machinery of B16 induced by quinoxalone was associated with drop in mitochondrial membrane potential from 5.35% to 23.7%, up-regulation of Bax and down-regulation of Bcl-2 in a dose-dependent manner. And a significant increased activation of caspase-3. Our finding suggests that quinoxalone could suppress the growth of B16 cells and reduces cell survival via disturbing mitochondrial membrane potential and inducing apoptosis of tumor cells.


2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Tae Hyuk Kim ◽  
Mi Ja Chung ◽  
Dae Jung Kim ◽  
Jin Kyoun You ◽  
Dong Joo Seo ◽  
...  

2007 ◽  
Vol 56 (12) ◽  
pp. 645-648 ◽  
Author(s):  
Mikio Kinoshita ◽  
Naofumi Hori ◽  
Kazuhiko Aida ◽  
Tatsuya Sugawara ◽  
Masao Ohnishi

2018 ◽  
Vol 24 (4) ◽  
pp. 627-633 ◽  
Author(s):  
Tomohiro Bito ◽  
Kyohei Koseki ◽  
Tomohiro Moriguchi ◽  
Yu Sasaki ◽  
Yukinori Yabuta ◽  
...  

2005 ◽  
Vol 53 (15) ◽  
pp. 6105-6111 ◽  
Author(s):  
Toshihiko Shoji ◽  
Saeko Masumoto ◽  
Nina Moriichi ◽  
Masuko Kobori ◽  
Tomomasa Kanda ◽  
...  

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