miR-544 Regulates Dairy Goat Male Germline Stem Cell Self-Renewal via Targeting PLZF

2015 ◽  
Vol 116 (10) ◽  
pp. 2155-2165 ◽  
Author(s):  
Wencong Song ◽  
Hailong Mu ◽  
Jiang Wu ◽  
Mingzhi Liao ◽  
Haijing Zhu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dairy Goat ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Male Germline

PLZF-Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a

2015 ◽  
Vol 117 (4) ◽  
pp. 844-852 ◽  
Author(s):  
Hailong Mu ◽  
Na Li ◽  
Jiang Wu ◽  
Liming Zheng ◽  
Yuanxin Zhai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Dairy Goat ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
Male Germline

scholarly journals miR‐34c works downstream of p53 leading to dairy goat male germline stem‐cell ( mGSC s) apoptosis

2013 ◽  
Vol 46 (2) ◽  
pp. 223-231 ◽  
Author(s):  
M. Li ◽  
M. Yu ◽  
C. Liu ◽  
H. Zhu ◽  
X. He ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dairy Goat ◽  
Germline Stem Cell ◽  
Male Germline

scholarly journals The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster

2009 ◽  
Vol 185 (4) ◽  
pp. 613-627 ◽  
Author(s):  
Akos Szakmary ◽  
Mary Reedy ◽  
Hongying Qi ◽  
Haifan Lin
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Double Mutant ◽  
Terminal Region ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Stem Cell Maintenance ◽  
Male Germline ◽  
Cytoplasmic Structures ◽  
Cell Maintenance

Yb regulates the proliferation of both germline and somatic stem cells in the Drosophila melanogaster ovary by activating piwi and hh expression in niche cells. In this study, we show that Yb protein is localized as discrete cytoplasmic spots exclusively in the somatic cells of the ovary and testis. These spots, which are different from all known cytoplasmic structures in D. melanogaster, are evenly electron-dense spheres 1.5 µm in diameter (herein termed the Yb body). The Yb body is frequently associated with mitochondria and a less electron-dense sphere of similar size that appears to be RNA rich. There are one to two Yb bodies/cell, often located close to germline cells. The N-terminal region of Yb is required for hh expression in niche cells, whereas the C-terminal region is required for localization to Yb bodies. The entire Yb protein is necessary for piwi expression in niche cells. A double mutant of Yb and a novel locus show male germline loss, revealing a function for Yb in male germline stem cell maintenance.

scholarly journals Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Cuie Chen ◽  
Mayu Inaba ◽  
Zsolt G Venkei ◽  
Yukiko M Yamashita
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Cell Fate ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Mother And Daughter ◽  
Stem Cell Divisions ◽  
Stem Cell Division ◽  
Male Germline Stem Cells

Asymmetric stem cell division is often accompanied by stereotypical inheritance of the mother and daughter centrosomes. However, it remains unknown whether and how stem cell centrosomes are uniquely regulated and how this regulation may contribute to stem cell fate. Here we identify Klp10A, a microtubule-depolymerizing kinesin of the kinesin-13 family, as the first protein enriched in the stem cell centrosome in Drosophila male germline stem cells (GSCs). Depletion of klp10A results in abnormal elongation of the mother centrosomes in GSCs, suggesting the existence of a stem cell-specific centrosome regulation program. Concomitant with mother centrosome elongation, GSCs form asymmetric spindle, wherein the elongated mother centrosome organizes considerably larger half spindle than the other. This leads to asymmetric cell size, yielding a smaller differentiating daughter cell. We propose that klp10A functions to counteract undesirable asymmetries that may result as a by-product of achieving asymmetries essential for successful stem cell divisions.

scholarly journals Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Jin Sun ◽  
Hui-Min Wei ◽  
Jiang Xu ◽  
Jian-Feng Chang ◽  
Zhihao Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epigenetic Regulation ◽  
Histone H1 ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
H4k16 Acetylation

scholarly journals Asymmetric Division of Drosophila Male Germline Stem Cell Shows Asymmetric Histone Distribution

Science ◽  
2012 ◽  
Vol 338 (6107) ◽  
pp. 679-682 ◽  
Author(s):  
V. Tran ◽  
C. Lim ◽  
J. Xie ◽  
X. Chen
Keyword(s):  
Stem Cell ◽  
Asymmetric Division ◽  
Germline Stem Cell ◽  
Male Germline

scholarly journals Loss-of-Function Screen Reveals Novel Regulators Required for Drosophila Germline Stem Cell Self-Renewal

2012 ◽  
Vol 2 (3) ◽  
pp. 343-351 ◽  
Author(s):  
Yalan Xing ◽  
Irina Kurtz ◽  
Manisha Thuparani ◽  
Jillian Legard ◽  
Hannele Ruohola-Baker
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Loss Of Function ◽  
Self Renewal

scholarly journals Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells

2012 ◽  
Vol 23 (8) ◽  
pp. 1524-1532 ◽  
Author(s):  
Therese M. Roth ◽  
C.-Y. Ason Chiang ◽  
Mayu Inaba ◽  
Hebao Yuan ◽  
Viktoria Salzmann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Stem Cell Regulation ◽  
Male Germline ◽  
Male Germline Stem Cells ◽  
Nutrient Conditions

Drosophila male germline stem cells (GSCs) divide asymmetrically, balancing self-renewal and differentiation. Although asymmetric stem cell division balances between self-renewal and differentiation, it does not dictate how frequently differentiating cells must be produced. In male GSCs, asymmetric GSC division is achieved by stereotyped positioning of the centrosome with respect to the stem cell niche. Recently we showed that the centrosome orientation checkpoint monitors the correct centrosome orientation to ensure an asymmetric outcome of the GSC division. When GSC centrosomes are not correctly oriented with respect to the niche, GSC cell cycle is arrested/delayed until the correct centrosome orientation is reacquired. Here we show that induction of centrosome misorientation upon culture in poor nutrient conditions mediates slowing of GSC cell proliferation via activation of the centrosome orientation checkpoint. Consistently, inactivation of the centrosome orientation checkpoint leads to lack of cell cycle slowdown even under poor nutrient conditions. We propose that centrosome misorientation serves as a mediator that transduces nutrient information into stem cell proliferation, providing a previously unappreciated mechanism of stem cell regulation in response to nutrient conditions.

scholarly journals A Drosophila Chromatin Factor Interacts With the Piwi-Interacting RNA Mechanism in Niche Cells to Regulate Germline Stem Cell Self-Renewal

Genetics ◽  
2010 ◽  
Vol 186 (2) ◽  
pp. 573-583 ◽  
Author(s):  
Tora K. Smulders-Srinivasan ◽  
Akos Szakmary ◽  
Haifan Lin
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Self Renewal
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