PLZF-Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a

2015 ◽  
Vol 117 (4) ◽  
pp. 844-852 ◽  
Author(s):  
Hailong Mu ◽  
Na Li ◽  
Jiang Wu ◽  
Liming Zheng ◽  
Yuanxin Zhai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Dairy Goat ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
Male Germline

scholarly journals Wolbachia Enhance Drosophila Stem Cell Proliferation and Target the Germline Stem Cell Niche

Science ◽  
2011 ◽  
Vol 334 (6058) ◽  
pp. 990-992 ◽  
Author(s):  
E. M. Fast ◽  
M. E. Toomey ◽  
K. Panaram ◽  
D. Desjardins ◽  
E. D. Kolaczyk ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
Cell Niche ◽  
Germline Stem Cell Niche

scholarly journals miR‐34c works downstream of p53 leading to dairy goat male germline stem‐cell ( mGSC s) apoptosis

2013 ◽  
Vol 46 (2) ◽  
pp. 223-231 ◽  
Author(s):  
M. Li ◽  
M. Yu ◽  
C. Liu ◽  
H. Zhu ◽  
X. He ◽  
...  
Keyword(s):  
Stem Cell ◽  
Dairy Goat ◽  
Germline Stem Cell ◽  
Male Germline

scholarly journals Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner

PLoS Biology ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. e2005004 ◽  
Author(s):  
Tomotsune Ameku ◽  
Yuto Yoshinari ◽  
Michael J. Texada ◽  
Shu Kondo ◽  
Kotaro Amezawa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Dependent Manner ◽  
Stem Cell Proliferation ◽  
Neuropeptide F

scholarly journals The exocyst complex regulates C. elegans germline stem cell proliferation by controlling membrane Notch levels

Development ◽  
2021 ◽  
Vol 148 (15) ◽  
Author(s):  
Kumari Pushpa ◽  
Sunayana Dagar ◽  
Harsh Kumar ◽  
Diksha Pathak ◽  
Sivaram V. S. Mylavarapu
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Plasma Membrane ◽  
Notch Signaling ◽  
Mammalian Cells ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans ◽  
Exocyst Complex ◽  
Membrane Density

ABSTRACT The conserved exocyst complex regulates plasma membrane-directed vesicle fusion in eukaryotes. However, its role in stem cell proliferation has not been reported. Germline stem cell (GSC) proliferation in the nematode Caenorhabditis elegans is regulated by conserved Notch signaling. Here, we reveal that the exocyst complex regulates C. elegans GSC proliferation by modulating Notch signaling cell autonomously. Notch membrane density is asymmetrically maintained on GSCs. Knockdown of exocyst complex subunits or of the exocyst-interacting GTPases Rab5 and Rab11 leads to Notch redistribution from the GSC-niche interface to the cytoplasm, suggesting defects in plasma membrane Notch deposition. The anterior polarity (aPar) protein Par6 is required for GSC proliferation, and for maintaining niche-facing membrane levels of Notch and the exocyst complex. The exocyst complex biochemically interacts with the aPar regulator Par5 (14-3-3ζ) and Notch in C. elegans and human cells. Exocyst components are required for Notch plasma membrane localization and signaling in mammalian cells. Our study uncovers a possibly conserved requirement of the exocyst complex in regulating GSC proliferation and in maintaining optimal membrane Notch levels.

scholarly journals Non-autonomous autophagy in germline stem cell proliferation

Cell Cycle ◽  
2017 ◽  
Vol 16 (16) ◽  
pp. 1481-1482 ◽  
Author(s):  
Kristina Ames ◽  
Alicia Meléndez
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation
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