scholarly journals The Limited Clinical Utility of Testosterone, Estradiol, and Sex Hormone Binding Globulin Measurements in the Prediction of Fracture Risk and Bone Loss in Older Men

2016 ◽  
Vol 32 (3) ◽  
pp. 633-640 ◽  
Author(s):  
Eric S Orwoll ◽  
Jodi Lapidus ◽  
Patty Y Wang ◽  
Liesbeth Vandenput ◽  
Andrew Hoffman ◽  
...  
Keyword(s):  
Bone Loss ◽  
Fracture Risk ◽  
Clinical Utility ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals The Effects of Serum Testosterone, Estradiol, and Sex Hormone Binding Globulin Levels on Fracture Risk in Older Men

2009 ◽  
Vol 94 (9) ◽  
pp. 3337-3346 ◽  
Author(s):  
Erin S. LeBlanc ◽  
Carrie M. Nielson ◽  
Lynn M. Marshall ◽  
Jodi A. Lapidus ◽  
Elizabeth Barrett-Connor ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Serum Testosterone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Sex Hormone-Binding Globulin Is Associated With Markers Of Vertebral Fracture And Vertebral Fracture Risk

2018 ◽  
Vol 21 (4) ◽  
pp. 609-610
Author(s):  
Enisa Shevroja ◽  
Fjorda Koromani ◽  
Taulant Muka ◽  
Ling Oei ◽  
Carola Zillikens ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Vertebral Fracture Risk

scholarly journals Sex hormone-binding globulin is associated with markers of vertebral fracture and vertebral fracture risk

2016 ◽  
Author(s):  
Fjorda Koromani ◽  
Taulant Muka ◽  
Ling Oei ◽  
Carola Zillikens ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Vertebral Fracture Risk

Exercise increases serum testosterone and sex hormone—binding globulin levels in older men

Metabolism ◽  
1996 ◽  
Vol 45 (8) ◽  
pp. 935-939 ◽  
Author(s):  
Joseph M. Zmuda ◽  
Paul D. Thompson ◽  
Stephen J. Winters
Keyword(s):  
Serum Testosterone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Contribution of Body Fatness and Adipose Tissue Distribution to the Age Variation in Plasma Steroid Hormone Concentrations in Men: The HERITAGE Family Study*

2000 ◽  
Vol 85 (3) ◽  
pp. 1026-1031 ◽  
Author(s):  
Charles Couillard ◽  
Jacques Gagnon ◽  
Jean Bergeron ◽  
Arthur S. Leon ◽  
D. C. Rao ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Steroid Hormone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Older Individuals ◽  
Hormone Binding ◽  
Body Fatness ◽  
Hormone Profile ◽  
Age Related

Abstract Obesity has been associated with alterations in plasma steroid hormone concentrations in men. Older men present an altered steroid hormone profile compared to younger individuals, and an increase in body fatness and changes in adipose tissue (AT) distribution are noted with advancing age. Thus, there is a need to examine the relative importance of increased body fatness and changes in AT distribution with advancing age to plasma steroid hormone and sex hormone-binding globulin levels in men. We, therefore, investigated the relationships among age, body fatness, AT distribution, and the plasma steroid hormone profile in a group of 217 Caucasian men (mean age ± sd, 36.2± 14.9 yr) who covered a wide age range (17–64 yr). Compared to young adult men, older men were characterized by increased adiposity (P < 0.0001) expressed either as body mass index or total body fat mass assessed by underwater weighing. Differences in AT distribution were also noted with a preferential accumulation of abdominal fat as indicated by a larger waist girth (P < 0.0001) and higher visceral AT accumulation (P < 0.0001), measured by computed tomography, in older subjects. Age was associated with decreases (P < 0.0001) in C19 adrenal steroid levels, namely reduced dehydroepiandrosterone (DHEA), DHEA fatty acid ester, DHEA sulfate, as well as androstenedione levels. Androgens, i.e. dihydrotestosterone and testosterone, were also affected by age, with lower levels of both steroids being found in older individuals (P < 0.0005). When statistical adjustment for body fatness and AT distribution was performed, differences in C19 adrenal steroids between the age groups remained significant, whereas differences in androgens and sex hormone-binding globulin concentrations were no longer significant. The present study suggests that age-related differences in plasma steroid hormone levels, especially androgens, are partly mediated by concomitant variation in adiposity in men.

scholarly journals The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: The osteoporotic fractures in men (MrOS) study

2012 ◽  
Vol 27 (11) ◽  
pp. 2306-2313 ◽  
Author(s):  
Elizabeth Barrett-Connor ◽  
Gail A Laughlin ◽  
Hong Li ◽  
Carrie M Nielson ◽  
P Ying Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Fracture Risk ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Sex Hormone ◽  
Hormone Deficiency

scholarly journals Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study

2008 ◽  
Vol 158 (6) ◽  
pp. 785-792 ◽  
Author(s):  
S A Paul Chubb ◽  
Zoë Hyde ◽  
Osvaldo P Almeida ◽  
Leon Flicker ◽  
Paul E Norman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Free Testosterone ◽  
Older Men ◽  
Community Dwelling ◽  
Sex Hormone ◽  
Mass Action ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Cross Sectional

BackgroundReduced circulating testosterone and sex hormone-binding globulin (SHBG) are implicated as risk factors for metabolic syndrome. As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in older men.MethodsWe conducted a cross-sectional study of 2502 community-dwelling men aged ≥70 years without known diabetes. Metabolic syndrome was defined using the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) criteria. Early morning fasting sera were assayed for total testosterone, SHBG and LH. Free testosterone was calculated using mass action equations.ResultsThere were 602 men with metabolic syndrome (24.1%). The risk of metabolic syndrome increased for total testosterone <20 nmol/l, SHBG <50 nmol/l and free testosterone <300 pmol/l. In univariate analyses SHBG was associated with all five components of metabolic syndrome, total testosterone was associated with all except hypertension, and free testosterone was associated only with waist circumference and triglycerides. In multivariate analysis, both total testosterone and especially SHBG remained associated with metabolic syndrome, with odds ratios of 1.34 (95% confidence interval (CI): 1.18–1.52) and 1.77 (95% CI: 1.53–2.06) respectively. Men with hypogonadotrophic hypogonadism (total testosterone <8 nmol/l, LH ≤12 IU/l) had the highest prevalence of metabolic syndrome (53%,P<0.001).ConclusionsLower SHBG is more strongly associated with metabolic syndrome than lower total testosterone in community-dwelling older men. SHBG may be the primary driver of these relationships, possibly reflecting its relationship with insulin sensitivity. Further studies should examine whether measures that raise SHBG protect against the development of metabolic syndrome in older men.

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