scholarly journals Sex hormone-binding globulin is associated with markers of vertebral fracture and vertebral fracture risk

2016 ◽  
Author(s):  
Fjorda Koromani ◽  
Taulant Muka ◽  
Ling Oei ◽  
Carola Zillikens ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Vertebral Fracture Risk

Sex Hormone-Binding Globulin Is Associated With Markers Of Vertebral Fracture And Vertebral Fracture Risk

2018 ◽  
Vol 21 (4) ◽  
pp. 609-610
Author(s):  
Enisa Shevroja ◽  
Fjorda Koromani ◽  
Taulant Muka ◽  
Ling Oei ◽  
Carola Zillikens ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Vertebral Fracture Risk

scholarly journals A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromsø Study

2007 ◽  
Vol 157 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Åshild Bjørnerem ◽  
Luai Awad Ahmed ◽  
Ragnar Martin Joakimsen ◽  
Gro K Rosvold Berntsen ◽  
Vinjar Fønnebø ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Vertebral Fractures ◽  
Sex Steroids ◽  
Bone Fragility ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Deficiency ◽  
Hormone Binding ◽  
Mineral Density ◽  
A Prospective Study

Objectives: As bone fragility is partly the result of sex hormone deficiency, we sought to determine whether circulating sex steroids or sex hormone-binding globulin (SHBG) predicts non-vertebral fractures. Methods: Forearm bone mineral density (BMD), total estradiol and testosterone, calculated free levels, and SHBG were measured in 1386 postmenopausal women and 1364 men aged 50–84 years at baseline in the Tromsø Study (1994–1995). Non-vertebral fractures were documented between 1994 and 2005. Results: During 8.4 years (range 0.01–10.4) of follow-up, 281 women and 105 men suffered non-vertebral fractures. For both sexes, fracture cases had lower BMD and higher SHBG, but sex steroids were not lower. Each standard deviation (s.d.) increase in SHBG increased non-vertebral fracture risk in women (hazards ratio (HR) 1.17; 95% confidence interval (CI) 1.03–1.33) and men (HR 1.26; 95% CI 1.03–1.54). After further adjustment for BMD, the risk was not statistically significant in women (HR 1.09; 95% CI 0.95–1.24) or men (HR 1.22; 95% CI 0.99–1.49). Each s.d. decrease in BMD increased fracture risk in women (HR 1.36; 95% CI 1.19–1.56) and men (HR 1.41; 95% CI 1.15–1.73). Fracture rates were highest in participants with SHBG in the highest tertile and BMD in the lowest tertile and were 37.9 and 17.0 per 1000 person-years in women and men respectively. However, in both sexes the combination of BMD and SHBG was no better predictor of fracture risk than BMD alone. Sex steroids were not associated with fracture risk. Conclusions: Measurements of sex steroids or SHBG are unlikely to assist in decision making regarding fracture risk susceptibility.

scholarly journals The Effects of Serum Testosterone, Estradiol, and Sex Hormone Binding Globulin Levels on Fracture Risk in Older Men

2009 ◽  
Vol 94 (9) ◽  
pp. 3337-3346 ◽  
Author(s):  
Erin S. LeBlanc ◽  
Carrie M. Nielson ◽  
Lynn M. Marshall ◽  
Jodi A. Lapidus ◽  
Elizabeth Barrett-Connor ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Serum Testosterone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Effects of oestradiol on sex hormone binding globulin

1982 ◽  
Vol 101 (2) ◽  
pp. 248-253 ◽  
Author(s):  
Viveca Odlind ◽  
Kerstin Elamsson ◽  
Doris E. Englund ◽  
Arne Victor ◽  
Elof D. B. Johansson
Keyword(s):  
Luteal Phase ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Pronounced Increase ◽  
Menstrual Cycles ◽  
Menopausal Women ◽  
Plasma Oestradiol

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

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