scholarly journals Testosterone, Dihydrotestosterone, Sex Hormone Binding Globulin and Incident Diabetes among Older Men: the Cardiovascular Health Study

2016 ◽  
pp. jc.2016-2623 ◽  
Author(s):  
Katherine E. Joyce ◽  
Mary L. Biggs ◽  
Luc Djoussé ◽  
Joachim H. Ix ◽  
Jorge R. Kizer ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Incident Diabetes ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Hormone Binding

scholarly journals Flavonoid Intake and Plasma Sex Steroid Hormones, Prolactin, and Sex Hormone-Binding Globulin in Premenopausal Women

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2669
Author(s):  
You Wu ◽  
Susan E. Hankinson ◽  
Stephanie A. Smith-Warner ◽  
Molin Wang ◽  
A. Heather Eliassen
Keyword(s):  
Linear Models ◽  
Geometric Mean ◽  
Plasma Concentrations ◽  
Premenopausal Women ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Health Study ◽  
Hormone Binding ◽  
Chemical Structures ◽  
Flavonoid Intake

Background: Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. Objective: To examine the relationship between flavonoid intake and sex hormone levels using timed blood samples in follicular and luteal phases in the Nurses’ Health Study II among premenopausal women. Methods: Plasma concentrations of estrogens, androgens, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), prolactin, and sex hormone-binding globulin (SHBG) were measured in samples collected between 1996 and 1999. Average flavonoid were calculated from semiquantitative food frequency questionnaires collected in 1995 and 1999. We used generalized linear models to calculate geometric mean hormone concentrations across categories of the intake of flavonoids and the subclasses. Results: Total flavonoid intake generally was not associated with the hormones of interest. The only significant association was with DHEAS (p-trend = 0.02), which was 11.1% (95% confidence interval (CI): −18.6%, −3.0%) lower comparing the highest vs. lowest quartile of flavonoid intake. In subclass analyses, the highest (vs. lowest) quartile of flavan-3-ol intake was associated with significantly lower DHEAS concentrations (−11.3% with 95% CI: −18.3%, −3.7%, p-trend = 0.01), and anthocyanin intake was associated with a significant inverse trend for DHEA (−18.0% with 95% CI: −27.9%, −6.7%, p-trend = 0.003). Conclusion: Flavonoid intake in this population had limited impact on most plasma sex hormones in premenopausal women. Anthocyanins and flavan-3-ols were associated with lower levels of DHEA and DHEAS.

scholarly journals Sex Steroids, Sex Hormone-Binding Globulin and Cardiovascular Health in Men and Postmenopausal Women: The Rotterdam Study

2016 ◽  
Vol 101 (7) ◽  
pp. 2844-2852 ◽  
Author(s):  
Loes Jaspers ◽  
Klodian Dhana ◽  
Taulant Muka ◽  
Cindy Meun ◽  
Jessica C. Kiefte-de Jong ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Sex Steroids ◽  
Cardiovascular Health ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Rotterdam Study ◽  
Hormone Binding

scholarly journals Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study

2018 ◽  
Vol 116 ◽  
pp. 239-247 ◽  
Author(s):  
Jason Y.Y. Wong ◽  
Helene G. Margolis ◽  
Mitchell Machiela ◽  
Weiyin Zhou ◽  
Michelle C. Odden ◽  
...  
Keyword(s):  
Air Pollution ◽  
Cardiovascular Health ◽  
Older Men ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Outdoor Air ◽  
Chromosome Y ◽  
Outdoor Air Pollution

287: Disability Risk and Transitions in Older Men with and without Prostate Cancer: Findings from the Cardiovascular Health Study

2007 ◽  
Vol 177 (4S) ◽  
pp. 96-96
Author(s):  
Sheila R. Gonzalgo ◽  
Mark L. Gonzalgo ◽  
Eleanor M. Simonsick ◽  
Mary Lou Biggs ◽  
Christopher I. Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cardiovascular Health ◽  
Older Men ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Biochemical Markers of Bone Turnover and Risk of Incident Diabetes in Older Women: The Cardiovascular Health Study

Diabetes Care ◽  
2018 ◽  
Vol 41 (9) ◽  
pp. 1901-1908 ◽  
Author(s):  
Daniele Massera ◽  
Mary L. Biggs ◽  
Marcella D. Walker ◽  
Kenneth J. Mukamal ◽  
Joachim H. Ix ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Older Women ◽  
Biochemical Markers ◽  
Cardiovascular Health ◽  
Incident Diabetes ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Markers Of Bone Turnover

Exercise increases serum testosterone and sex hormone—binding globulin levels in older men

Metabolism ◽  
1996 ◽  
Vol 45 (8) ◽  
pp. 935-939 ◽  
Author(s):  
Joseph M. Zmuda ◽  
Paul D. Thompson ◽  
Stephen J. Winters
Keyword(s):  
Serum Testosterone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Contribution of Body Fatness and Adipose Tissue Distribution to the Age Variation in Plasma Steroid Hormone Concentrations in Men: The HERITAGE Family Study*

2000 ◽  
Vol 85 (3) ◽  
pp. 1026-1031 ◽  
Author(s):  
Charles Couillard ◽  
Jacques Gagnon ◽  
Jean Bergeron ◽  
Arthur S. Leon ◽  
D. C. Rao ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Steroid Hormone ◽  
Older Men ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Older Individuals ◽  
Hormone Binding ◽  
Body Fatness ◽  
Hormone Profile ◽  
Age Related

Abstract Obesity has been associated with alterations in plasma steroid hormone concentrations in men. Older men present an altered steroid hormone profile compared to younger individuals, and an increase in body fatness and changes in adipose tissue (AT) distribution are noted with advancing age. Thus, there is a need to examine the relative importance of increased body fatness and changes in AT distribution with advancing age to plasma steroid hormone and sex hormone-binding globulin levels in men. We, therefore, investigated the relationships among age, body fatness, AT distribution, and the plasma steroid hormone profile in a group of 217 Caucasian men (mean age ± sd, 36.2± 14.9 yr) who covered a wide age range (17–64 yr). Compared to young adult men, older men were characterized by increased adiposity (P < 0.0001) expressed either as body mass index or total body fat mass assessed by underwater weighing. Differences in AT distribution were also noted with a preferential accumulation of abdominal fat as indicated by a larger waist girth (P < 0.0001) and higher visceral AT accumulation (P < 0.0001), measured by computed tomography, in older subjects. Age was associated with decreases (P < 0.0001) in C19 adrenal steroid levels, namely reduced dehydroepiandrosterone (DHEA), DHEA fatty acid ester, DHEA sulfate, as well as androstenedione levels. Androgens, i.e. dihydrotestosterone and testosterone, were also affected by age, with lower levels of both steroids being found in older individuals (P < 0.0005). When statistical adjustment for body fatness and AT distribution was performed, differences in C19 adrenal steroids between the age groups remained significant, whereas differences in androgens and sex hormone-binding globulin concentrations were no longer significant. The present study suggests that age-related differences in plasma steroid hormone levels, especially androgens, are partly mediated by concomitant variation in adiposity in men.

scholarly journals Association of skeletal muscle mass, kidney disease and mortality in older men and women: the cardiovascular health study

Aging ◽  
2020 ◽  
Vol 12 (21) ◽  
pp. 21023-21036
Author(s):  
Nicholas T. Kruse ◽  
Petra Buzkova ◽  
Joshua I. Barzilay ◽  
Rodrigo J. Valderrabano ◽  
John A. Robbins ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Kidney Disease ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Cardiovascular Health ◽  
Older Men ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Men And Women ◽  
Older Men And Women
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