scholarly journals The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: The osteoporotic fractures in men (MrOS) study

2012 ◽  
Vol 27 (11) ◽  
pp. 2306-2313 ◽  
Author(s):  
Elizabeth Barrett-Connor ◽  
Gail A Laughlin ◽  
Hong Li ◽  
Carrie M Nielson ◽  
P Ying Wang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Fracture Risk ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Sex Hormone ◽  
Hormone Deficiency

scholarly journals Pharmacologic treatment of osteoporosis – 2011

2011 ◽  
Vol 152 (33) ◽  
pp. 1320-1326 ◽  
Author(s):  
Péter Lakatos
Keyword(s):  
Bone Loss ◽  
Fracture Risk ◽  
Hormone Replacement ◽  
Treatment Options ◽  
Osteoporotic Fractures ◽  
Cost Effective ◽  
Similar Efficacy ◽  
High Fracture ◽  
Efficient Treatment ◽  
Treatment Of Osteoporosis

Osteoporosis affects approximately 9% of the population in Hungary resulting in about 100 000 osteoporotic fractures annually. Thirty-five percent of patients with hip fractures due to osteoporosis will die within 1 year. Direct costs of osteoporosis exceed 25 billion forints per year. Apparently, cost-effective reduction of bone loss and consequent fracture risk will add up to not only financial savings but improvement in quality of life, as well. A number of pharmacological modalities are available for this purpose. The mainstay of the treatment of osteoporosis is the bisphosphonate group that includes effective anti-resorptive compounds mitigating bone loss and fragility. The recently registered denosumab exhibits similar efficacy by neutralizing RANK ligand, however, marked differences can be observed between the two drug classes. Strontium has a unique mechanism of action by rebalancing bone turnover, and thus, providing an efficient treatment option for the not fast bone losers who are at high fracture risk. The purely anabolic teriparatide is available for the extremely severe osteoporotic patients and for those who do not respond to other types of therapy. Older treatment options such as hormone replacement therapy, raloxifene, tibolone or calcitonin may also have a restricted place in the management of osteoporosis. Orv. Hetil., 2011, 152, 1320–1326.

scholarly journals Bone Loss at the Hip and Subsequent Mortality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study

JBMR Plus ◽  
2017 ◽  
Vol 1 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Peggy M Cawthon ◽  
Sheena Patel ◽  
Susan K Ewing ◽  
Li-Yung Lui ◽  
Jane A Cauley ◽  
...  
Keyword(s):  
Bone Loss ◽  
Osteoporotic Fractures ◽  
Older Men

scholarly journals Pins and Plaster Aren’t Enough: A Call for the Evaluation and Treatment of Patients with Osteoporotic Fractures

2003 ◽  
Vol 88 (8) ◽  
pp. 3482-3486 ◽  
Author(s):  
Ethel S. Siris ◽  
John P. Bilezikian ◽  
Mishaela R. Rubin ◽  
Dennis M. Black ◽  
Richard S. Bockman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Fracture Risk ◽  
Primary Care Physicians ◽  
Osteoporotic Fractures ◽  
Standard Of Care ◽  
Pharmacological Therapy ◽  
Diagnostic Tools ◽  
Osteoporosis Therapy ◽  
Call To Action ◽  
History Of

A history of an osteoporotic fracture is a powerful predictor of future fractures. Older patients who sustain low trauma fractures are candidates for interventions that should include confirmation of the diagnosis of osteoporosis, adequate calcium and vitamin D administration, and use of an osteoporosis therapy that is proven to lower fracture risk. Recently, however, several reports in the literature have indicated that, in general, those physicians who diagnose and treat fractures, i.e. radiologists, orthopedic surgeons, physiatrists, and those who provide general medical care to these fracture patients, the primary care physicians, are not evaluating patients with acute fractures for the presence of osteoporosis and are not prescribing calcium, vitamin D, or specific pharmacological therapy to reduce future fracture risk. These reports suggest that implementation of a standard of care for the subsequent medical management of the older patient with an acute fracture is needed urgently. Diagnostic tools and several effective therapies exist, but these are underused by the physicians who interface with these patients. A call to action is necessary to reduce the human and economic costs associated with this serious and treatable disease.

Longitudinal Study of Bone Density and Periodontal Disease in Men

2007 ◽  
Vol 86 (11) ◽  
pp. 1110-1114 ◽  
Author(s):  
K.R. Phipps ◽  
B.K.S. Chan ◽  
T.E. Madden ◽  
N.C. Geurs ◽  
M.S. Reddy ◽  
...  
Keyword(s):  
Bone Loss ◽  
Periodontal Disease ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Whole Body ◽  
Mineral Density ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
X Ray ◽  
Periodontal Destruction

Bone loss is a feature of both periodontitis and osteoporosis, and periodontal destruction may be influenced by systemic bone loss. This study evaluated the association between periodontal disease and bone mineral density (BMD) in a cohort of 1347 (137 edentulous) older men followed for an average of 2.7 years. Participants were recruited from the Osteoporotic Fractures in Men Study. Random half-mouth dental measures included clinical attachment loss (CAL), pocket depth (PD), calculus, plaque, and bleeding. BMD was measured at the hip, spine, and whole-body, by dual-energy x-ray absorptiometry, and at the heel by ultrasound. After adjustment for age, smoking, race, education, body mass index, and calculus, there was no association between number of teeth, periodontitis, periodontal disease progression, and either BMD or annualized rate of BMD change. We found little evidence of an association between periodontitis and skeletal BMD among older men.

Nutrition, Physical Activity, and Bone Health in Women

1998 ◽  
Vol 8 (3) ◽  
pp. 250-284 ◽  
Author(s):  
Richard D. Lewis ◽  
Christopher M. Modlesky
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Bone Loss ◽  
Fracture Risk ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Positive Impact ◽  
Calcium Supplementation ◽  
Weight Bearing ◽  
Calcium Excretion

Calcium and vitamin D can significantly impact bone mineral and fracture risk in women. Unfortunately, calcium intakes in women are low and many elderly have poor vitamin D status. Supplementation with calcium (~1000 mg) can reduce bone loss in premenopausal and late postmenopausal women, especially at sites that have a high cortical bone composition. Vitamin D supplementation slows bone loss and reduces fracture rates in late postmenopausal women. While an excess of nutrients such as sodium and protein potentially affect bone mineral through increased calcium excretion, phytoestrogens in soy foods may attenuate bone loss ihrough eslrogenlike activity. Weight-bearing physical activity may reduce the risk of osteoporosis in women by augmenting bone mineral during the early aduli years and reducing the loss of bone following menopause. High-load activities, such as resistance training, appear to provide the best stimulus for enhancing bone mineral; however, repetitive activities, such as walking, may have a positive impact on bone mineral when performed at higher intensities. Irrespective of changes in bone mineral, physical activities that improve muscular strength, endurance, and balance may reduce fracture risk by reducing the risk of falling. The combined effect of physical activity and calcium supplementation on bone mineral needs further investigation.

scholarly journals HYPOVITAMINOSIS D AND MENOPAUSE: STILL AN ISSUE IN 2016?

2016 ◽  
Vol 63 (3) ◽  
pp. 209-210
Author(s):  
Adina Ghemigian ◽  
◽  
Otilia Radu ◽  
Ana Valea ◽  
Nicoleta Dumitru ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Meta Analysis ◽  
Osteoporotic Fractures ◽  
Hypovitaminosis D ◽  
Mineral Density ◽  
Level Of Evidence ◽  
Knowing That ◽  
Risk Increase ◽  
Risk Of Falls

Vitamin D in menopause is essential for skeleton and metabolic involvement. Our purpose is to introduce the level of evidence regarding menopause – related hypovitaminosis D through a brief review of papers published on PubMed in 2016. The correlation between low vitamin D and risk of falls is a traditional observation. Lack of vitamin D remains one of the major contributors to osteoporotic fractures which have an annual incidence of 8.9 million worldwide. Yale FIT trial referring to menopausal cancer survivors after 12 months of aerobic physical exercise confirmed the bone loss under aromatase inhibitors opposite to tamoxifen is significant, a bone loss that is lower if vitamin D ranges are low. Arzoxifene Generations Trial followed for 5 years menopausal women treated only with vitamin D and calcium and found a fracture risk increase by 46% for each unit of lumbar T-score that decreases. A meta-analysis of 34 studies on 11,090 patients treated with ibandronate showed that hypovitaminosis D at baseline is a predictor of bone mineral density improvement only at lumbar spine. Another study revealed that 77% of menopausal females have 25-hydoxyvitamin D (25-OH D) less than 30 ng/mL while a negative correlation between 25-OH D and waist circumference was found knowing that android fat disposition in women with hipovitaminosis D is a hallmark of metabolic syndrome. Overall, in 2016, PubMed published papers regarding vitamin D in menopause still reflect its deficiency and associated metabolic risk.

scholarly journals BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)

2011 ◽  
Vol 26 (3) ◽  
pp. 496-502 ◽  
Author(s):  
Carrie M Nielson ◽  
Lynn M Marshall ◽  
Annette L Adams ◽  
Erin S LeBlanc ◽  
Peggy M Cawthon ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Osteoporotic Fractures ◽  
Older Men

scholarly journals Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study

2012 ◽  
Vol 27 (11) ◽  
pp. 2314-2324 ◽  
Author(s):  
Lang Yang ◽  
Annabel C Burton ◽  
Mike Bradburn ◽  
Carrie M Nielson ◽  
Eric S Orwoll ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Bone Density ◽  
Fracture Risk ◽  
Proximal Femur ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Hip Fracture Risk
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