scholarly journals Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet's induced membrane in a critical size defect model in the rat's femur

2020 ◽  
Vol 108 (4) ◽  
pp. 1469-1482 ◽  
Author(s):  
Maximilian Leiblein ◽  
Elias Koch ◽  
Andreas Winkenbach ◽  
Alexander Schaible ◽  
Christoph Nau ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Healing ◽  
Critical Size ◽  
Bone Graft Substitute ◽  
Granule Size ◽  
Defect Model ◽  
Critical Size Defect ◽  
Induced Membrane

Influence of the induced membrane filled with syngeneic bone and regenerative cells on bone healing in a critical size defect model of the rat’s femur

Injury ◽  
2018 ◽  
Vol 49 (10) ◽  
pp. 1721-1731 ◽  
Author(s):  
Christoph Nau ◽  
Sebastian Simon ◽  
Alexander Schaible ◽  
Caroline Seebach ◽  
Katrin Schröder ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect ◽  
Induced Membrane ◽  
Regenerative Cells

Validation of a Femoral Critical Size Defect Model for Orthotopic Evaluation of Bone Healing: A Biomechanical, Veterinary and Trauma Surgical Perspective

2008 ◽  
Vol 14 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Inga Drosse ◽  
Elias Volkmer ◽  
Sebastian Seitz ◽  
Hermann Seitz ◽  
Rainer Penzkofer ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect

scholarly journals Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model

2020 ◽  
Author(s):  
Maximilian Leiblein ◽  
Andreas Winkenbach ◽  
Elias Koch ◽  
Alexander Schaible ◽  
Hubert Büchner ◽  
...  
Keyword(s):  
Critical Size ◽  
Callus Formation ◽  
Healing Time ◽  
Granule Size ◽  
Critical Size Defect ◽  
Induced Membrane ◽  
Masquelet Technique ◽  
Membrane Technique ◽  
Induced Membrane Technique

Abstract Purpose The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. Compared to mature periosteum, the induced membrane differs significantly. However, both play a crucial role in bone regeneration. As part of a histological and radiological post-evaluation of an earlier project, we analyzed the influence of the granule size of the bone void filler Herafill® on development of periosteum regrowth in a critical size defect. Methods We compared three different sizes of Herafill® granules (Heraeus Medical GmbH, Wehrheim) in vivo in a rat femoral critical size defect (10 mm) treated with the induced membrane technique. After 8 weeks healing time, femurs were harvested and taken for histological and radiological analysis. Results A significantly increased regrowth of periosteum into the defect was found when small granules were used. Large granules showed significantly increased occurrence of bone capping. Small granules lead to significant increase in callus formation in the vicinity to the membrane. Conclusion The size of Herafill® granules has significant impact on the development of periosteal-like structures around the defect using Masquelet’s induced membrane technique. Small granules show significantly increased regrowth of periosteum and improved bone formation adjacent to the induced membrane.

scholarly journals Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur

Apmis ◽  
2019 ◽  
Vol 127 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Werner Hettwer ◽  
Peter F. Horstmann ◽  
Sabine Bischoff ◽  
Daniel Güllmar ◽  
Jürgen R. Reichenbach ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Metaphyseal Bone

Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat's femur

Injury ◽  
2016 ◽  
Vol 47 (2) ◽  
pp. 325-334 ◽  
Author(s):  
Christoph Nau ◽  
Caroline Seebach ◽  
Alexander Trumm ◽  
Alexander Schaible ◽  
Kerstin Kontradowitz ◽  
...  
Keyword(s):  
Bone Cement ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect ◽  
Induced Membrane

scholarly journals A Standardized Critical Size Defect Model in Normal and Osteoporotic Rats to Evaluate Bone Tissue Engineered Constructs

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Livia Poser ◽  
Romano Matthys ◽  
Peter Schawalder ◽  
Simon Pearce ◽  
Mauro Alini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Animal Model ◽  
Bone Healing ◽  
Wistar Rats ◽  
Critical Size ◽  
Osteoporotic Bone ◽  
Defect Model ◽  
Critical Size Defect ◽  
Titanium Screws ◽  
Fixation System

Tissue engineered constructs should be tested for their efficacy not only in normal but also in osteoporotic bone. The rat is an established animal model for osteoporosis and is used often for bone healing studies. In this study a defined and standardized critical size defect model in the rat suitable for screening new tissue engineered constructs in normal and osteoporotic bone is described and validated. Normal and ovariectomised Wistar rats received a unilateral middiaphyseal 5 mm defect in the femur, which was instrumented with a radiolucent PEEK plate fixed with angular stable titanium screws and left untreated. All animals were euthanized eight weeks after defect surgery and the bone healing was evaluated using radiographs, computed tomography measurements, and histology. The developed fixation system provided good stability, even in osteoporotic bone. The implants and ancillary instruments ensured consistent and facile placement of the PEEK plates. The untreated defects did not heal without intervention making the model a well-defined and standardized critical size defect model highly useful for evaluating tissue engineered solutions in normal and osteoporotic bone.

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