scholarly journals Interleukin‐4 overexpressing mesenchymal stem cells within gelatin‐based microribbon hydrogels enhance bone healing in a murine long bone critical‐size defect model

2020 ◽  
Vol 108 (11) ◽  
pp. 2240-2250 ◽  
Author(s):  
Masaya Ueno ◽  
Chi‐Wen Lo ◽  
Danial Barati ◽  
Bogdan Conrad ◽  
Tzuhua Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Healing ◽  
Critical Size ◽  
Interleukin 4 ◽  
Long Bone ◽  
Defect Model ◽  
Critical Size Defect

scholarly journals Improved healing of critical-size femoral defect in osteoporosis rat models using 3D elastin/polycaprolactone/nHA scaffold in combination with mesenchymal stem cells

2021 ◽  
Vol 32 (3) ◽  
Author(s):  
Fatemeh Hejazi ◽  
Vahid Ebrahimi ◽  
Mehrdad Asgary ◽  
Abbas Piryaei ◽  
Mohammad Javad Fridoni ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Healing ◽  
Critical Size ◽  
Therapeutic Potential ◽  
Rna Extraction ◽  
Osteotomy Site ◽  
Cell Groups ◽  
The Right

AbstractOsteoporosis is a common bone disease that results in elevated risk of fracture, and delayed bone healing and impaired bone regeneration are implicated by this disease. In this study, Elastin/Polycaprolactone/nHA nanofibrous scaffold in combination with mesenchymal stem cells were used to regenerate bone defects. Cytotoxicity, cytocompatibility and cellular morphology were evaluated in vitro and observations revealed that an appropriate environment for cellular attachment, growth, migration, and proliferation is provided by this scaffold. At 3 months following ovariectomy (OVX), the rats were used as animal models with an induced critical size defect in the femur to evaluate the therapeutic potential of osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) seeded on 3 dimension (3D) scaffolds. In this experimental study, 24 female Wistar rats were equally divided into three groups: Control, scaffold (non-seeded BM-MSC), and scaffold + cell (seeded BM-MSC) groups. 30 days after surgery, the right femur was removed, and underwent a stereological analysis and RNA extraction in order to examine the expression of Bmp-2 and Vegf genes. The results showed a significant increase in stereological parameters and expression of Bmp-2 and Vegf in scaffold and scaffold + cell groups compared to the control rats. The present study suggests that the use of the 3D Elastin/Polycaprolactone (PCL)/Nano hydroxyapatite (nHA) scaffold in combination with MSCs may improve the fracture regeneration and accelerates bone healing at the osteotomy site in rats.

Validation of a Femoral Critical Size Defect Model for Orthotopic Evaluation of Bone Healing: A Biomechanical, Veterinary and Trauma Surgical Perspective

2008 ◽  
Vol 14 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Inga Drosse ◽  
Elias Volkmer ◽  
Sebastian Seitz ◽  
Hermann Seitz ◽  
Rainer Penzkofer ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Defect Model ◽  
Critical Size Defect

Xenogenic Transplantation of Human Mesenchymal Stem Cells in a Critical Size Defect of the Sheep Tibia for Bone Regeneration

2010 ◽  
Vol 16 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Philipp Niemeyer ◽  
Thomas S. Schönberger ◽  
Joachim Hahn ◽  
Philip Kasten ◽  
Joerg Fellenberg ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Critical Size ◽  
Human Mesenchymal Stem Cells ◽  
Critical Size Defect

Combined therapy of adipose-derived stem cells and photobiomodulation on accelerated bone healing of a critical size defect in an osteoporotic rat model

2020 ◽  
Vol 530 (1) ◽  
pp. 173-180
Author(s):  
Mehrdad Asgari ◽  
Rouhallah Gazor ◽  
Mohammad-Amin Abdollahifar ◽  
Fatemeh Fadaei Fathabady ◽  
Fatemeh Zare ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Healing ◽  
Rat Model ◽  
Critical Size ◽  
Combined Therapy ◽  
Adipose Derived Stem Cells ◽  
Critical Size Defect
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