scholarly journals Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur

Apmis ◽  
2019 ◽  
Vol 127 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Werner Hettwer ◽  
Peter F. Horstmann ◽  
Sabine Bischoff ◽  
Daniel Güllmar ◽  
Jürgen R. Reichenbach ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Metaphyseal Bone

scholarly journals 405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Aljawadi ◽  
I Madhi ◽  
T Naylor ◽  
M Elmajee ◽  
A Islam ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Thickness ◽  
Bone Graft Substitute ◽  
Fracture Site ◽  
Open Fractures ◽  
X Rays ◽  
Radiographic Images ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

Porous Beta-Calcium Pyrophosphate as a Bone Graft Substitute in a Canine Bone Defect Model

2003 ◽  
Vol 240-242 ◽  
pp. 399-402 ◽  
Author(s):  
Jae Hyup Lee ◽  
D.H. Lee ◽  
Hyun Seung Ryu ◽  
Bong-Soon Chang ◽  
Kug Sun Hong ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Bone Graft Substitute ◽  
Calcium Pyrophosphate ◽  
Defect Model

scholarly journals The Annals of Biomedical Engineering on Critical Size Bone Defect: A Review

2021 ◽  
Author(s):  
Azimah Ahmad Zainol Hady ◽  
Liyana Azmi ◽  
Amira Raudhah Abdullah
Keyword(s):  
Bone Graft ◽  
Fracture Healing ◽  
Bone Defect ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Bone Graft Substitute ◽  
Physiological Process ◽  
Mechanical Stabilization ◽  
Bone Injury

Bone can heal on its own through the process known as bone remodelling. Nonetheless, a critical size bone defect will hinder the natural bone-healing process and may not allow for complete fracture healing. These requires surgical intervention by employing the use of bone tissue implants and in need of realignment and fixation for proper fracture healing. Traditional knowledge of bone injury and fracture healing must be comprehended thoroughly for a proper invention of bioengineered material or devices that could enhance the physiological process. Heretofore, engineered materials used to address critical size bone defects have encountered various challenges and improvement be it in bone grafting or choices of mechanical stabilization devices. To date, researchers have been mainly focussing on the alternative material for bone graft substitute albeit the selection of fixators to establish mechanical stabilization are as important. This review highlighted the challenges, improvement and advancement in mechanical stabilization devices and bone graft substitute with respect to the physiological process of bone fracture healing. Identifying these challenges would help assist the researcher in an expedition toward the recovery and restoration of critical size bone defects.

scholarly journals Synthetic Bone Graft Substitute for Treatment of Unicameral Bone Cysts

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Carl Nunziato ◽  
John Williams ◽  
Ronald Williams
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Bone Cysts ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

TOBRAMYCIN ELUTION FROM BONE SUBSTITUTE

2000 ◽  
Vol 04 (02) ◽  
pp. 129-134 ◽  
Author(s):  
M. W. Lawless ◽  
R. T. Laughlin ◽  
J. M. Kerpsack ◽  
D. Pisut
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Test Tube ◽  
Sterile Water ◽  
Delivery Vehicle ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Autologous Grafts ◽  
Phosphate Buffered Saline ◽  
Antibiotic Level

Purpose: To determine the rate of antibiotic elution from tobramycin-impregnated ProOsteon (Interpore) and Collagraft (Zimmer). Methods: Five samples of Collagraft and ProOsteon were impregnated with a solution containing 1.2 g of tobramycin and 10 ml of sterile water. The samples were then allowed to dry overnight. These samples were stored at 37°C in separate test tubes containing phosphate buffered saline (PBS). The solution in each test tube was removed with a pipette at hours 3, 6, 9 and 12 and days 1, 2, 3, 5, 7, 9, 11 and 13. The PBS was then replaced. The pipetted solution was sent for laboratory quantification and also used in a bioassay to determine antibiotic level. To serve as a control, two additional samples of each bone graft that were not impregnated with antibiotic were placed in separate test tubes and subjected to the same protocol. Results: The antibiotic elution rate for both ProOsteon and Collagraft was high at 3 hours [5362 and 4875 μg/ml on day 3 (3.1 μg/ml) for the Collagraft and day 7 (3.7 μg/ml) for the ProOsteon]. Effective intravenous tobramycin level is considered to be 4–6 μg/ml. Conclusion: Bone graft substitute can be used as a delivery vehicle for tobramycin. In addition, antibiotic-impregnated synthetic bone graft may potentially fill a dead space or cavitary defect without the need for large autologous grafts and does not require later removal.

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