Tailoring of multilayered core-shell nanostructure for multicomponent administration and controllable release of biologically active ions

2008 ◽  
Vol 85A (4) ◽  
pp. 909-918 ◽  
Author(s):  
Zhongru Gou ◽  
Wenjian Weng ◽  
Piyi Du ◽  
Gaorong Han ◽  
Weiqi Yan
Keyword(s):  
Biologically Active ◽  
Core Shell ◽  
Controllable Release

Tailoring of Multilayer Core-Shell Structure for the Controllable Release of Biologically Active Silicon and Strontium Ions

2007 ◽  
Vol 330-332 ◽  
pp. 1057-1060
Author(s):  
Zhong Ru Gou ◽  
Wen Jian Weng ◽  
Ja Bei Zhou ◽  
Pi Yi Du ◽  
Gao Rong Han
Keyword(s):  
Controlled Release ◽  
Three Dimensional ◽  
Octacalcium Phosphate ◽  
Biologically Active ◽  
Core Shell ◽  
Layer By Layer ◽  
Dependent Manner ◽  
Lbl Assembly ◽  
Controllable Release ◽  
Strontium Ions

Nanocomposites consisting of biologically active ions, which can enhance cell viability and activate gene expression, are regarded as promising bone regenerative materials. We report a new method for the layer-by-layer (LbL) assembly of biologically active strontium ions in the core-shell Silica@OCP system for an efficient controlled-release. The strontium ions were assembled by using a pH-responsive electrostatic interaction to generate three-dimensional gradients within the silica nanospheres, and then a porous OCP (octacalcium phosphate) shells was coated on the microunits tailored by polyelectrolyte molecules. This core-shell-like microstructure can achieve the multicomponents administration and controlled release of essential trace silicon and zinc ions based on the barrier effect of OCP shell and pH-dependent manner, respectively.

Core-shell based nanocarriers as delivery systems for biologically active metal ions and drugs

2008 ◽  
Vol 132 (3) ◽  
pp. e32-e33 ◽  
Author(s):  
M.A. Quadir ◽  
C. Treiber ◽  
G. Multhaup ◽  
M. Körner ◽  
R. Haag
Keyword(s):  
Metal Ions ◽  
Delivery Systems ◽  
Biologically Active ◽  
Core Shell ◽  
Active Metal

Core–shell particles for controllable release of drug

2015 ◽  
Vol 125 ◽  
pp. 108-120 ◽  
Author(s):  
Dinggeng He ◽  
Shuo Wang ◽  
Lei Lei ◽  
Zengtao Hou ◽  
Peng Shang ◽  
...  
Keyword(s):  
Core Shell ◽  
Controllable Release ◽  
Shell Particles

scholarly journals Core–Shell Fibers: Design, Roles, and Controllable Release Strategies in Tissue Engineering and Drug Delivery

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2008 ◽  
Author(s):  
Muhammad Faiq Abdullah ◽  
Tamrin Nuge ◽  
Andri Andriyana ◽  
Bee Chin Ang ◽  
Farina Muhamad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Clinical Applications ◽  
Bioactive Molecules ◽  
Core Shell ◽  
Therapeutic Effects ◽  
Design Requirement ◽  
Preparation Methods ◽  
Controllable Release ◽  
Future Direction

The key attributes of core–shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core–shell fibers, followed by the summary of recent preparation methods of core–shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core–shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core–shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.

A novel route to fabricate the biomedical material: Structure strategy and the biologically active ions controllable release

2006 ◽  
Vol 116 (3) ◽  
pp. 360-364 ◽  
Author(s):  
Zhongru Gou ◽  
Wenjian Weng ◽  
Weiqi Yan ◽  
Piyi Du ◽  
Gaorong Han ◽  
...  
Keyword(s):  
Biologically Active ◽  
Material Structure ◽  
Biomedical Material ◽  
Controllable Release

scholarly journals Green fabrication of biologically active magnetic core-shell Fe3O4/Au nanoparticles and their potential anticancer effect

2019 ◽  
Vol 96 ◽  
pp. 51-57 ◽  
Author(s):  
Zahra Izadiyan ◽  
Kamyar Shameli ◽  
Mikio Miyake ◽  
Sin-Yeang Teow ◽  
Suat-Cheng Peh ◽  
...  
Keyword(s):  
Au Nanoparticles ◽  
Magnetic Core ◽  
Biologically Active ◽  
Core Shell ◽  
Anticancer Effect

Chromatographic behavior of the biologically active proline derivative captopril on particulate, monolithic and core–shell narrow bore columns

2012 ◽  
Vol 4 (12) ◽  
pp. 4373
Author(s):  
Constantinos K. Zacharis ◽  
Theano D. Karakosta ◽  
Paraskevas D. Tzanavaras ◽  
Pantelis G. Rigas ◽  
Demetrius G. Themelis
Keyword(s):  
Biologically Active ◽  
Chromatographic Behavior ◽  
Core Shell ◽  
Narrow Bore Columns
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