scholarly journals Combined antitumor effects of bee venom and cisplatin on human cervical and laryngeal carcinoma cells and their drug resistant sublines

2013 ◽  
Vol 34 (12) ◽  
pp. 1332-1341 ◽  
Author(s):  
Goran Gajski ◽  
Tamara Čimbora-Zovko ◽  
Sanjica Rak ◽  
Marko Rožman ◽  
Maja Osmak ◽  
...  
Keyword(s):  
Laryngeal Carcinoma ◽  
Carcinoma Cells ◽  
Bee Venom ◽  
Drug Resistant ◽  
Antitumor Effects

FTIR spectroscopy reveals lipid droplets in drug resistant laryngeal carcinoma cells through detection of increased ester vibrational bands intensity

The Analyst ◽  
2014 ◽  
Vol 139 (13) ◽  
pp. 3407-3415 ◽  
Author(s):  
Sanjica Rak ◽  
Tihana De Zan ◽  
Jasminka Stefulj ◽  
Marin Kosović ◽  
Ozren Gamulin ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Ftir Spectroscopy ◽  
Laryngeal Carcinoma ◽  
Lipid Droplets ◽  
Multidrug Resistant ◽  
Carcinoma Cells ◽  
Drug Resistant ◽  
Lipid Droplet Formation ◽  
Cholesteryl Ester Content ◽  
Vibrational Bands

Specific differences in FTIR spectra of HEp-2 cells and their multidrug resistant 7T subline were observed and the increased cholesteryl ester content and enhanced lipid droplet formation in 7T cells were verified.

scholarly journals MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell Carcinoma Cells by Targeting Astrocyte Elevated Gene 1

2018 ◽  
Vol 26 (3) ◽  
pp. 457-466 ◽  
Author(s):  
Haitao Song ◽  
Yanwei Rao ◽  
Gang Zhang ◽  
Xiangbo Kong
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Bioinformatic Analysis ◽  
Carcinoma Cells ◽  
Luciferase Reporter ◽  
Reporter Assay ◽  
Antitumor Effects ◽  
Potential Therapeutic Target

MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. In this study, we aimed to investigate the potential function of miR-384 in regulating tumorigenesis in RCC. Here we found that miR-384 was significantly downregulated in RCC tissues and cell lines. Overexpression of miR-384 significantly inhibited the growth and invasion of RCC cells, whereas inhibition of miR-384 had the opposite effects. Bioinformatic analysis and luciferase reporter assay showed that miR-384 directly targeted the 3′-untranslated region of astrocyte elevated gene 1 (AEG-1). Further data showed that miR-384 could negatively regulate the expression of AEG-1 in RCC cells. Importantly, miR-384 expression was inversely correlated with AEG-1 expression in clinical RCC specimens. Moreover, miR-384 regulates the activation of Wnt signaling. Overexpression of AEG-1 significantly reversed the antitumor effects of miR-384. Overall, these findings suggest that miR-384 suppresses the growth and invasion of RCC cells via downregulation of AEG-1, providing a potential therapeutic target for the treatment of RCC.

scholarly journals Genotoxic Effects of Green Tea Extract on Human Laryngeal Carcinoma Cells In Vitro

2011 ◽  
Vol 62 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Ksenija Durgo ◽  
Sandra Kostić ◽  
Katarina Gradiški ◽  
Draženka Komes ◽  
Maja Osmak ◽  
...  
Keyword(s):  
Cell Line ◽  
Green Tea ◽  
Laryngeal Carcinoma ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Green Tea Extract ◽  
Carcinoma Cells ◽  
Tea Extract ◽  
Human Laryngeal Carcinoma

Genotoxic Effects of Green Tea Extract on Human Laryngeal Carcinoma Cells In VitroGreen tea (Camellia sinensis) contains several bioactive compounds which protect the cell and prevent tumour development. Phytochemicals in green tea extract (mostly flavonoids) scavenge free radicals, but also induce pro-oxidative reactions in the cell. In this study, we evaluated the potential cytotoxic and prooxidative effects of green tea extract and its two main flavonoid constituents epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) on human laryngeal carcinoma cell line (HEp2) and its cross-resistant cell line CK2. The aim was to see if the extract and its two flavonoids could increase the sensitivity of the cisplatin-resistant cell line CK2 in comparison to the parental cell line. The results show that EGCG and green tea extract increased the DNA damage in the CK2 cell line during short exposure. The cytotoxicity of EGCG and ECG increased with the time of incubation. Green tea extract induced lipid peroxidation in the CK2 cell line. The pro-oxidant effect of green tea was determined at concentrations higher than those found in traditionally prepared green tea infusions.

Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells

2018 ◽  
Vol 121 (10) ◽  
pp. 4009-4021 ◽  
Author(s):  
Li Wu ◽  
Xiao Liu ◽  
Ke Xin Cao ◽  
Zi hui Ni ◽  
Wei Dong Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Antitumor Effects ◽  
Hepatocellular Carcinoma Cells

scholarly journals Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects

2003 ◽  
Vol 10 (10) ◽  
pp. 771-778 ◽  
Author(s):  
Shin-ichi Ugai ◽  
Osamu Shimozato ◽  
Ling Yu ◽  
Yan-Qing Wang ◽  
Kiyoko Kawamura ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Pancreatic Carcinoma ◽  
Natural Killer ◽  
Killer Cell ◽  
Carcinoma Cells ◽  
Antitumor Effects
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