Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells

2018 ◽  
Vol 121 (10) ◽  
pp. 4009-4021 ◽  
Author(s):  
Li Wu ◽  
Xiao Liu ◽  
Ke Xin Cao ◽  
Zi hui Ni ◽  
Wei Dong Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Antitumor Effects ◽  
Hepatocellular Carcinoma Cells

scholarly journals Synergistic antitumor effects of tanshinone IIA and sorafenib or its derivative SC-1 in hepatocellular carcinoma cells

2018 ◽  
Vol Volume 11 ◽  
pp. 1777-1785 ◽  
Author(s):  
Chien-Ming Chiu ◽  
Sung-Ying Huang ◽  
Shu-Fang Chang ◽  
Kuan-Fu Liao ◽  
Sheng-Chun Chiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Tanshinone Iia ◽  
Antitumor Effects ◽  
Hepatocellular Carcinoma Cells

scholarly journals miR-100 Suppresses the Proliferation, Invasion, and Migration of Hepatocellular Carcinoma Cells via Targeting CXCR7

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yiman Ge ◽  
Jia Shu ◽  
Gang Shi ◽  
Fuguo Yan ◽  
Yejing Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Luciferase Reporter ◽  
Antitumor Effects ◽  
Hepatocellular Carcinoma Cells ◽  
Invasion And Migration ◽  
Reporter Assays ◽  
Underlying Mechanisms ◽  
And Migration ◽  
Endothelial Growth Factor

This study is to elucidate the functions of miR-100 in hepatocellular carcinoma progression and to explore the underlying mechanisms. Expression levels of miR-100 in normal-cancer hepatocellular carcinoma tissues were measured using quantitative real-time PCR (qRT-PCR). The invasive and proliferative abilities of hepatocellular carcinoma cell lines transfected with mimic-NC or mimic-miR-100 were measured using transwell, CCK-8, and colony formation assays. The binding sites between CXCR7 and miR-100 were determined using luciferase reporter assays. The correlation of CXCR7 and miR-100 in hepatocellular carcinoma progression was further confirmed by cotransfection assays. Our results showed that miR-100 was significantly lower expressed in hepatocellular carcinoma tissues and negatively associated with CXCR7 expression. Cell functional assays’ results found that upregulation of miR-100 inhibited the proliferative, invasive, and migrative abilities in hepatocellular carcinoma cells. Luciferase reporter assay suggested that CXCR7 mRNA and miR-100 bound one another. Increasing CXCR7 expression reversed the inhibitive effects of upregulated miR-100 in hepatocellular carcinoma cells. Further study showed that miR-100/CXCR7 played a role in hepatocellular carcinoma progression by regulating metalloproteinase-2 (MMP2) and vascular endothelial growth factor (VEGF). Conclusively, miR-100 exerts antitumor effects on hepatocellular carcinoma. Overexpression of miR-100 attenuates the invasive and proliferative abilities of hepatocellular carcinoma cells by targeting CXCR7.

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