scholarly journals Western Diet Changes Gut Microbiota and Ameliorates Liver Injury in a Mouse Model with Human‐Like Bile Acid Composition

2021 ◽  
Author(s):  
Junichi Iwamoto ◽  
Akira Honda ◽  
Teruo Miyazaki ◽  
Tadakuni Monma ◽  
Hajime Ueda ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Acid Composition ◽  
Western Diet

Crosstalk between gut microbiota and host lipid metabolism in a mouse model of alcoholic liver injury by chronic baijiu or ethanol feeding

2022 ◽  
Author(s):  
Cheng Fang ◽  
Qingwu Zhou ◽  
Qingyang Liu ◽  
Wei Jia ◽  
Yan Xu
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Alcoholic Beverage ◽  
Alcoholic Liver Injury ◽  
Ethanol Feeding

This study demonstrates that compounds in baijiu, a traditional Chinese alcoholic beverage, can attenuate the development of ethanol-induced liver injury by regulating the crosstalk between gut microbiota and host lipid metabolism.

scholarly journals Live and Diet by Your Gut Microbiota

mBio ◽  
2019 ◽  
Vol 10 (5) ◽  
Author(s):  
Christine M. Bassis
Keyword(s):  
Mouse Model ◽  
Gut Microbiota ◽  
Western Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Future Studies ◽  
Microbiota Analysis ◽  
Lethal Sepsis

ABSTRACT Diet influences health in multiple ways. One important effect of diet is on the gut microbiota. The effects of diet are often related to an individual’s specific microbiota composition. The close links between health, diet, and gut microbiota are illustrated in a new mouse model of sepsis where the combination of a high-fat/low-fiber Western diet, antibiotics, and surgery promotes the development of lethal sepsis. Diet can also influence infection via the gut microbiota beyond sepsis. Future studies with this model may inform the use of microbiota analysis and personalized diets to protect surgery patients from infection and sepsis.

Crosstalk between Bile Acids and Gut Microbiota and Its Impact on Farnesoid X Receptor Signalling

2017 ◽  
Vol 35 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Annika Wahlström ◽  
Petia Kovatcheva-Datchary ◽  
Marcus Ståhlman ◽  
Fredrik Bäckhed ◽  
Hanns-Ulrich Marschall
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Mouse Models ◽  
Acid Composition ◽  
Farnesoid X Receptor ◽  
Special Importance ◽  
Human Gut ◽  
Substantial Impact ◽  
Human Gut Microbiota

Background: The gut microbiota has a substantial impact on health and disease. The human gut microbiota influences the development and progression of metabolic diseases; however, the underlying mechanisms are not fully understood. The nuclear farnesoid X receptor (FXR), which regulates bile acid homeostasis and glucose and lipid metabolism, is activated by primary human and murine bile acids, chenodeoxycholic acid and cholic acid, while rodent specific primary bile acids tauromuricholic acids antagonise FXR activation. The gut microbiota deconjugates and subsequently metabolises primary bile acids into secondary bile acids in the gut and thereby changes FXR activation and signalling. Key Message: Mouse models have been used to study the crosstalk between bile acids and the gut microbiota, but the substantial differences in bile acid composition between humans and mice need to be considered when interpreting data from such studies and for the development of so-called humanised mouse models. Conclusion: It is of special importance to elucidate how a human gut microbiota influences bile acid composition and FXR signalling in colonised mice.

Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis

2019 ◽  
Vol 379 ◽  
pp. 114664 ◽  
Author(s):  
Takahiro Suga ◽  
Hiroaki Yamaguchi ◽  
Jiro Ogura ◽  
Saori Shoji ◽  
Masamitsu Maekawa ◽  
...  
Keyword(s):  
Bile Acid ◽  
Mouse Model ◽  
Acid Composition ◽  
Alcoholic Steatohepatitis

scholarly journals Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn’s disease

2021 ◽  
Author(s):  
Shigeki Bamba ◽  
Osamu Inatomi ◽  
Atsushi Nishida ◽  
Masashi Ohno ◽  
Takayuki Imai ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Bile Acid ◽  
Crohn's Disease ◽  
Gut Microbiota ◽  
Acid Composition ◽  
Ileal Mucosa

scholarly journals Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice

2009 ◽  
Vol 37 (5) ◽  
pp. 1035-1045 ◽  
Author(s):  
Lisa D. Beilke ◽  
Lauren M. Aleksunes ◽  
Ricky D. Holland ◽  
David G. Besselsen ◽  
Rick D. Beger ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Acid Composition ◽  
Lithocholic Acid ◽  
Constitutive Androstane Receptor

NorUDCA improves liver injury and glucose sensitivity in a mouse model of obesity and steatosis

2015 ◽  
Vol 53 (05) ◽  
Author(s):  
D Steinacher ◽  
T Claudel ◽  
T Stojakovic ◽  
M Trauner
Keyword(s):  
Liver Injury ◽  
Mouse Model ◽  
Glucose Sensitivity

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

2019 ◽  
Author(s):  
T Liwinski ◽  
R Zenouzi ◽  
C John ◽  
H Ehlken ◽  
MC Rühlemann ◽  
...  
Keyword(s):  
Bile Acid ◽  
Primary Sclerosing Cholangitis ◽  
Acid Composition ◽  
Sclerosing Cholangitis
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