scholarly journals Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice

2009 ◽  
Vol 37 (5) ◽  
pp. 1035-1045 ◽  
Author(s):  
Lisa D. Beilke ◽  
Lauren M. Aleksunes ◽  
Ricky D. Holland ◽  
David G. Besselsen ◽  
Rick D. Beger ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Acid Composition ◽  
Lithocholic Acid ◽  
Constitutive Androstane Receptor

scholarly journals Obeticholic Acid Protects Against Cholestatic Liver Injury Induced by Lithocholic Acid via Inhibiting Exogenous Cell Apoptosis

2021 ◽  
Author(s):  
Yangping Zhu ◽  
Changling Wang ◽  
Jingyi Yu ◽  
Yingying Miao ◽  
Yuanyuan Chai ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Lithocholic Acid ◽  
Farnesoid X Receptor ◽  
Multi Drug Resistance ◽  
Caspase 8 ◽  
Obeticholic Acid ◽  
Cholestatic Liver Injury

Abstract Background: Lithocholic acid (LCA) is one kind of endogenous bile acids which is a typical index in primary biliary cholangitis (PBC). It could cause severe cholestatic liver injury in rodents. Obeticholic acid (OCA) is a major treatment for PBC. However, its effect and mechanism in LCA-induced liver injury was still unclear beside of bile acid regulation. This study aims to evaluate the hepatoprotective effect and mechanism of OCA against LCA-induced cholestatic liver injury. Results: LCA-induced upregulations of ALT, AST, ALP and TBA were reduced and the bile acid profiles in serum, liver and bile were improved significantly by OCA. This bile acid regulating effect of OCA was mainly based on increasing the expression of bile acid efflux transporters bile salt export pump (BSEP), multidrug resistant associated protein 2 (MRP2), MRP3 and multi-drug resistance 3 (MDR3) instead of bile acid synthesis inhibition. Furthermore, it was found that OCA reduced the activation and expression of Caspase 8/3 signaling pathway without the change of p-MLKL and BAX in LCA-induced cholestatic model. And the inhibition of Caspase 8/3 signaling pathway depended on the activation of Farnesoid X receptor (FXR) to inhibit Caspase 8 cleavage to form a active complex.Conclusions: This study found OCA improved LCA-induced cholestatic liver injury via FXR-induced exogenous cell apoptosis, which provided a new evidence for the application of OCA to ameliorate PBC in clinical.

scholarly journals Psychiatric Comorbidities and Liver Injury Are Associated With Unbalanced Plasma Bile Acid Profile During Methamphetamine Withdrawal

2022 ◽  
Vol 12 ◽  
Author(s):  
Yuru Ma ◽  
Hongjin Wu ◽  
Huawei Wang ◽  
Fengrong Chen ◽  
Zhenrong Xie ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Psychiatric Symptoms ◽  
Lithocholic Acid ◽  
Plasma Concentrations ◽  
Alanine Transaminase ◽  
Gas Liquid Chromatography ◽  
Psychiatric Comorbidities ◽  
Control Subjects ◽  
Liver Functions

BackgroundThe pathogenesis of methamphetamine usedisorders (MUDs) remains largely unknown; however, bile acids may play arole as potential mediators of liver injury and psychiatric comorbidities.The aim of this study was to characterize bile acid (BA) profiles in plasmaof patients with MUDs undergoing withdrawal.MethodsLiver functions and psychiatric symptoms wereevaluated in a retrospective cohort (30 MUDs versus 30 control subjects) andan exploratory cohort (30 MUDs including 10 subjects each at the 7-day,3-month, and 12-month withdrawal stages versus 10 control subjects). BAcompositions in plasma samples from MUD patients in the exploratory cohortwere determined by gas-liquid chromatography.ResultsBoth psychiatric comorbidities andmethamphetamine-induced liver injury were observed in patients in both MUDcohorts. The plasma concentrations of the total BA, cholic acid (CA), andchenodeoxycholic acid (CDCA) were lower in MUD patients relative tocontrols. The maximum decline was observed at the 3-month stage, withgradual recovery at the 12-month stage. Notably, the ratios of deoxycholicacid (DCA)/CA and lithocholic acid (LCA)/CDCA were statistically significantat the 3-month stage comparing with controls. Significant correlations werefound between the LCA/CDCA and taurolithocholic acid (TLCA)/CDCA ratios andthe levels of alanine transaminase and aspartate aminotransferase, andbetween the LCA/CDCA ratio and the HAM-A score.ConclusionBA profile during METH withdrawal weremarkedly altered, with these unbalanced BAs being associated with liverinjury. The associations between BA profiles and psychiatric symptomssuggest an association between specific BAs and disease progression,possibly through the liver-brain axis.

scholarly journals TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury

2012 ◽  
Vol 53 (12) ◽  
pp. 2698-2707 ◽  
Author(s):  
Tsutomu Matsubara ◽  
Naoki Tanaka ◽  
Misako Sato ◽  
Dong Wook Kang ◽  
Kristopher W. Krausz ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Lithocholic Acid ◽  
Phospholipid Metabolism ◽  
Hepatic Bile

scholarly journals Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Gut ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 446-452 ◽  
Author(s):  
C M P Rodrigues ◽  
J J G Marín ◽  
D Brites
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Bile Acids ◽  
Cholic Acid ◽  
Acid Composition ◽  
Lithocholic Acid ◽  
Maternal Serum ◽  
Total Bile Acid ◽  
Serum Bile Acid ◽  
Cholestasis Of Pregnancy

BACKGROUNDData on meconium bile acid composition in newborn babies of patients with intrahepatic cholestasis of pregnancy (ICP) are relatively scant, and changes that occur on ursodeoxycholic acid (UDCA) administration have not been evaluated.AIMSTo investigate bile acid profiles in meconium of neonates from untreated and UDCA treated patients with ICP. Maternal serum bile acid composition was also analysed both at diagnosis and delivery to determine whether this influences the concentration and proportion of bile acids in the meconium.PATIENTS/METHODSThe population included eight healthy pregnant women and 16 patients with ICP, nine of which received UDCA (12.5–15.0 mg/kg body weight/day) for 15±4 days until parturition. Bile acids were assessed in the meconium by gas chromatography-mass spectrometry and in maternal serum by high performance liquid chromatography.RESULTSTotal bile acid and cholic acid concentrations in the meconium were increased (p<0.01) in newborns from patients with ICP (13.5 (5.1) and 8.4 (4.1) μmol/g respectively; mean (SEM)) as compared with controls (2.0 (0.5) and 0.8 (0.3) μmol/g respectively), reflecting the total bile acid and cholic acid levels in the maternal serum (r = 0.85 and r = 0.84, p<0.01). After UDCA administration, total bile acid concentrations decreased in the mother (∼3-fold, p<0.05) but not in the meconium. UDCA concentration in the meconium showed only a 2-fold increase after treatment, despite the much greater increase in the maternal serum (p<0.01). Lithocholic acid concentration in the meconium was not increased by UDCA treatment.CONCLUSIONSUDCA administration does not influence the concentration and proportion of bile acids in the meconium, which in turn are altered by ICP. Moreover, this beneficial treatment for the mother does not increase meconium levels of potentially toxic metabolites of UDCA such as lithocholic acid.

scholarly journals Western Diet Changes Gut Microbiota and Ameliorates Liver Injury in a Mouse Model with Human‐Like Bile Acid Composition

2021 ◽  
Author(s):  
Junichi Iwamoto ◽  
Akira Honda ◽  
Teruo Miyazaki ◽  
Tadakuni Monma ◽  
Hajime Ueda ◽  
...  
Keyword(s):  
Bile Acid ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Acid Composition ◽  
Western Diet

Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis

2019 ◽  
Author(s):  
T Liwinski ◽  
R Zenouzi ◽  
C John ◽  
H Ehlken ◽  
MC Rühlemann ◽  
...  
Keyword(s):  
Bile Acid ◽  
Primary Sclerosing Cholangitis ◽  
Acid Composition ◽  
Sclerosing Cholangitis

Pharmacological effects of secondary bile acid microparticles in diabetic murine model

2020 ◽  
Vol 16 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Bozica Kovacevic ◽  
Corina Mihaela Ionescu ◽  
Giuseppe Luna ◽  
...  
Keyword(s):  
Bile Acid ◽  
Blood Glucose ◽  
Bile Acids ◽  
Lithocholic Acid ◽  
Diabetes Treatment ◽  
Secondary Bile Acid ◽  
Glucose Levels ◽  
Anti Inflammatory ◽  
Antidiabetic Effects

Aim: Examine bile acids effects in Type 2 diabetes. Background: In recent studies, the bile acid ursodeoxycholic acid (UDCA) has shown potent anti-inflammatory effects in obese patients while in type 2 diabetics (T2D) levels of the pro-inflammatory bile acid lithocholic acid were increased, and levels of the anti-inflammatory bile acid chenodeoxycholic acid were decreased, in plasma. Objective: Hence, this study aimed to examine applications of novel UDCA nanoparticles in diabetes. Methods: Diabetic balb/c adult mice were divided into three equal groups and gavaged daily with either empty microcapsules, free UDCA, or microencapsulated UDCA over two weeks. Their blood, tissues, urine, and faeces were collected for blood glucose, inflammation, and bile acid analyses. UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Results: UDCA resulted in modulatory effects on bile acids profile without antidiabetic effects suggesting that bile acid modulation was not directly linked to diabetes treatment. Conclusion: Bile acids modulated the bile profile without affecting blood glucose levels.

scholarly journals Metabolism of sulfonate analogs of ursodeoxycholic acid and their effects on biliary bile acid composition in hamsters.

1993 ◽  
Vol 34 (3) ◽  
pp. 429-435
Author(s):  
T Mikami ◽  
K Kihira ◽  
S Ikawa ◽  
M Yoshii ◽  
S Miki ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Acid Composition ◽  
Biliary Bile Acid

Bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary sludge

2017 ◽  
Vol 78 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Toshiaki Kakimoto ◽  
Hideyuki Kanemoto ◽  
Kenjiro Fukushima ◽  
Koichi Ohno ◽  
Hajime Tsujimoto
Keyword(s):  
Bile Acid ◽  
Acid Composition ◽  
Biliary Sludge
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