Nanoscaled porphyrinic metal–organic framework for photodynamic/photothermal therapy of tumor

2019 ◽  
Vol 40 (16-17) ◽  
pp. 2204-2210 ◽  
Author(s):  
Shengyan Wang ◽  
Weihua Chen ◽  
Chunhuan Jiang ◽  
Lehui Lu
Keyword(s):  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

scholarly journals Metal–Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy

ACS Omega ◽  
2017 ◽  
Vol 2 (3) ◽  
pp. 1249-1258 ◽  
Author(s):  
Zhengfang Tian ◽  
Xianxian Yao ◽  
Kexin Ma ◽  
Xingxing Niu ◽  
Julia Grothe ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Graphene Quantum Dot ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy

2020 ◽  
Vol Volume 15 ◽  
pp. 3235-3250 ◽  
Author(s):  
Haibin Guo ◽  
Yanqing Xia ◽  
Ke Feng ◽  
Xiaowei Qu ◽  
Cuilian Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Surface Engineering ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Stimuli-responsive multifunctional metal–organic framework nanoparticles for enhanced chemo-photothermal therapy

2019 ◽  
Vol 7 (6) ◽  
pp. 994-1004 ◽  
Author(s):  
Jie Feng ◽  
Zhen Xu ◽  
Ping Dong ◽  
Wenqian Yu ◽  
Feng Liu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Efficient Delivery ◽  
Metal Organic ◽  
Delivery Vehicles ◽  
Organic Framework

Programmable metal–organic frameworks were prepared as efficient delivery vehicles for targeted and stimuli-responsive release of multi-therapeutics with excellent antitumor activity.

Albumin/sulfonamide stabilized iron porphyrin metal organic framework nanocomposites: targeting tumor hypoxia by carbonic anhydrase IX inhibition and T1–T2 dual mode MRI guided photodynamic/photothermal therapy

2018 ◽  
Vol 6 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Wei Zhu ◽  
Yao Liu ◽  
Zhe Yang ◽  
Li Zhang ◽  
Liji Xiao ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Tumor Hypoxia ◽  
Carbonic Anhydrase Ix ◽  
Iron Porphyrin ◽  
Dual Mode ◽  
Metal Organic ◽  
Mri Guided ◽  
Organic Framework

We report BSA and SA stabilized iron porphyrin MOF nanocomposites with tremendous potential in tumor hypoxic imaging guided PDT and PTT.

Facile synthesis of a metal–organic framework nanocarrier for NIR imaging-guided photothermal therapy

2018 ◽  
Vol 6 (11) ◽  
pp. 2918-2924 ◽  
Author(s):  
Yawei Li ◽  
Na Xu ◽  
Junli Zhou ◽  
Wenhe Zhu ◽  
Letian Li ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Metal Organic Framework ◽  
Facile Synthesis ◽  
Zeolitic Imidazolate Framework ◽  
Nir Imaging ◽  
Metal Organic ◽  
Facile Route ◽  
Organic Framework

Near infrared Cy dye was efficiently embedded into zeolitic imidazolate framework-8 by a facile route for further using in the imaging-guided photothermal therapy.

Nanoscale Polymer Metal-Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

2016 ◽  
Vol 28 (42) ◽  
pp. 9320-9325 ◽  
Author(s):  
Weiqi Wang ◽  
Lei Wang ◽  
Yang Li ◽  
Shi Liu ◽  
Zhigang Xie ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Colon Cancers ◽  
Polymer Metal ◽  
Metal Organic ◽  
Organic Framework

Metal-Organic Framework Nanoshuttle for Synergistic Photodynamic and Low-Temperature Photothermal Therapy

2018 ◽  
Vol 28 (42) ◽  
pp. 1804634 ◽  
Author(s):  
Kai Zhang ◽  
Xiangdan Meng ◽  
Yu Cao ◽  
Zhou Yang ◽  
Haifeng Dong ◽  
...  
Keyword(s):  
Low Temperature ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework
Sign in / Sign up

Export Citation Format

Share Document