Metal-Organic Framework Nanoshuttle for Synergistic Photodynamic and Low-Temperature Photothermal Therapy

2018 ◽  
Vol 28 (42) ◽  
pp. 1804634 ◽  
Author(s):  
Kai Zhang ◽  
Xiangdan Meng ◽  
Yu Cao ◽  
Zhou Yang ◽  
Haifeng Dong ◽  
...  
2019 ◽  
Vol 40 (16-17) ◽  
pp. 2204-2210 ◽  
Author(s):  
Shengyan Wang ◽  
Weihua Chen ◽  
Chunhuan Jiang ◽  
Lehui Lu

2019 ◽  
Vol 7 (14) ◽  
pp. 8129-8135 ◽  
Author(s):  
Yanru Guo ◽  
Xing Gao ◽  
Chunmei Zhang ◽  
Yong Wu ◽  
Xinghua Chang ◽  
...  

Low temperature NH3 plasma modification of Ni MOF-74 yields a highly efficient hydrogen evolution catalyst with a carambola-like hierarchical 3D structure, which is composed of ultrafine Ni nanocrystals encapsulated in a thin layer of N doped carbon.


Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.


ACS Omega ◽  
2017 ◽  
Vol 2 (3) ◽  
pp. 1249-1258 ◽  
Author(s):  
Zhengfang Tian ◽  
Xianxian Yao ◽  
Kexin Ma ◽  
Xingxing Niu ◽  
Julia Grothe ◽  
...  

Polyhedron ◽  
2015 ◽  
Vol 90 ◽  
pp. 18-22 ◽  
Author(s):  
Takhyeon Kim ◽  
Dae Han Kim ◽  
Seungik Kim ◽  
Young Dok Kim ◽  
Youn-Sang Bae ◽  
...  

2020 ◽  
Vol Volume 15 ◽  
pp. 3235-3250 ◽  
Author(s):  
Haibin Guo ◽  
Yanqing Xia ◽  
Ke Feng ◽  
Xiaowei Qu ◽  
Cuilian Zhang ◽  
...  

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