scholarly journals Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy

2020 ◽  
Vol Volume 15 ◽  
pp. 3235-3250 ◽  
Author(s):  
Haibin Guo ◽  
Yanqing Xia ◽  
Ke Feng ◽  
Xiaowei Qu ◽  
Cuilian Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Surface Engineering ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Surface Engineering Layered Metal-Organic Framework to Enhance Processability and Stability in Water

ChemNanoMat ◽  
2017 ◽  
Vol 3 (12) ◽  
pp. 902-908 ◽  
Author(s):  
Yung-Lin Li ◽  
Heng-Yu Chi ◽  
Ming-Yang Kan ◽  
Szu-Ying Pao ◽  
Yu-Hao Kang ◽  
...  
Keyword(s):  
Surface Engineering ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Nanoscaled porphyrinic metal–organic framework for photodynamic/photothermal therapy of tumor

2019 ◽  
Vol 40 (16-17) ◽  
pp. 2204-2210 ◽  
Author(s):  
Shengyan Wang ◽  
Weihua Chen ◽  
Chunhuan Jiang ◽  
Lehui Lu
Keyword(s):  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

scholarly journals Metal–Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy

ACS Omega ◽  
2017 ◽  
Vol 2 (3) ◽  
pp. 1249-1258 ◽  
Author(s):  
Zhengfang Tian ◽  
Xianxian Yao ◽  
Kexin Ma ◽  
Xingxing Niu ◽  
Julia Grothe ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Graphene Quantum Dot ◽  
Metal Organic ◽  
Organic Framework

Covalent surface modification of a metal–organic framework: selective surface engineering via CuI-catalyzed Huisgen cycloaddition

2008 ◽  
pp. 5493 ◽  
Author(s):  
Tendai Gadzikwa ◽  
Guang Lu ◽  
Charlotte L. Stern ◽  
Scott R. Wilson ◽  
Joseph T. Hupp ◽  
...  
Keyword(s):  
Surface Modification ◽  
Surface Engineering ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal-Organic Framework Surface Functionalization: GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness (Small 40/2018)

Small ◽  
2018 ◽  
Vol 14 (40) ◽  
pp. 1870182 ◽  
Author(s):  
Mónica Giménez-Marqués ◽  
Elena Bellido ◽  
Thomas Berthelot ◽  
Teresa Simón-Yarza ◽  
Tania Hidalgo ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Surface Engineering ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Stimuli-responsive multifunctional metal–organic framework nanoparticles for enhanced chemo-photothermal therapy

2019 ◽  
Vol 7 (6) ◽  
pp. 994-1004 ◽  
Author(s):  
Jie Feng ◽  
Zhen Xu ◽  
Ping Dong ◽  
Wenqian Yu ◽  
Feng Liu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Efficient Delivery ◽  
Metal Organic ◽  
Delivery Vehicles ◽  
Organic Framework

Programmable metal–organic frameworks were prepared as efficient delivery vehicles for targeted and stimuli-responsive release of multi-therapeutics with excellent antitumor activity.

Albumin/sulfonamide stabilized iron porphyrin metal organic framework nanocomposites: targeting tumor hypoxia by carbonic anhydrase IX inhibition and T1–T2 dual mode MRI guided photodynamic/photothermal therapy

2018 ◽  
Vol 6 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Wei Zhu ◽  
Yao Liu ◽  
Zhe Yang ◽  
Li Zhang ◽  
Liji Xiao ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Tumor Hypoxia ◽  
Carbonic Anhydrase Ix ◽  
Iron Porphyrin ◽  
Dual Mode ◽  
Metal Organic ◽  
Mri Guided ◽  
Organic Framework

We report BSA and SA stabilized iron porphyrin MOF nanocomposites with tremendous potential in tumor hypoxic imaging guided PDT and PTT.

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