scholarly journals Synthesis of [(1,2,3-Triazol-1-yl)methyl]boronic Acids Through Click Chemistry: Easy Access to a Potential Scaffold for Protease Inhibitors

2015 ◽  
Vol 2015 (5) ◽  
pp. 1075-1083 ◽  
Author(s):  
Chiara Romagnoli ◽  
Emilia Caselli ◽  
Fabio Prati
Keyword(s):  
Click Chemistry ◽  
Protease Inhibitors ◽  
Boronic Acids ◽  
Easy Access

Highly diastereoselective entry to chiral oxindole-based β-amino boronic acids and spiro derivatives

2021 ◽  
Author(s):  
Marco Manenti ◽  
Stefano Gazzotti ◽  
Leonardo Lo Presti ◽  
Giorgio Molteni ◽  
Alessandra Silvani
Keyword(s):  
Boronic Acids ◽  
Spiro Compounds ◽  
Easy Access ◽  
Spiro Derivatives ◽  
Quaternary Stereocenters

We here describe the first Cu-catalysed, diastereoselective 1,2-addition of 1,1-diborylmethane to chiral ketimines for the synthesis of quaternary stereocenters and spiro compounds. The method provides easy access to a range...

scholarly journals Doubly Dynamic Self-Healing Materials Based on Oxime Click Chemistry and Boronic Acids

2017 ◽  
Vol 38 (6) ◽  
pp. 1600760 ◽  
Author(s):  
Joe Collins ◽  
Milena Nadgorny ◽  
Zeyun Xiao ◽  
Luke A. Connal
Keyword(s):  
Click Chemistry ◽  
Boronic Acids ◽  
Self Healing

scholarly journals Selective glycoprotein detection through covalent templating and allosteric click-imprinting

2015 ◽  
Vol 6 (9) ◽  
pp. 5114-5119 ◽  
Author(s):  
Alexander Stephenson-Brown ◽  
Aaron L. Acton ◽  
Jon A. Preece ◽  
John S. Fossey ◽  
Paula M. Mendes
Keyword(s):  
Click Chemistry ◽  
Boronic Acids ◽  
The Self ◽  
Binding Affinities ◽  
Bottom Up ◽  
High Binding ◽  
Self Assembled ◽  
Reversible Covalent ◽  
Covalent Interactions

A hierarchical bottom-up route exploiting reversible covalent interactions with boronic acids and so-called click chemistry for selective glycoprotein detection is described. The self-assembled and imprinted surfaces confer high binding affinities, nanomolar sensitivity, exceptional glycoprotein specificity and selectivity.

scholarly journals Click Chemistry in Lead Optimization of Boronic Acids as β-Lactamase Inhibitors

2015 ◽  
Vol 58 (14) ◽  
pp. 5445-5458 ◽  
Author(s):  
Emilia Caselli ◽  
Chiara Romagnoli ◽  
Roza Vahabi ◽  
Magdalena A. Taracila ◽  
Robert A. Bonomo ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Boronic Acids ◽  
Lead Optimization

Synthesis of Chiral Triazole-Based Halogen Bond Donors

Synthesis ◽  
2019 ◽  
Vol 51 (10) ◽  
pp. 2128-2135 ◽  
Author(s):  
Mikk Kaasik ◽  
Sandra Kaabel ◽  
Kadri Kriis ◽  
Ivar Järving ◽  
Tõnis Kanger
Keyword(s):  
Click Chemistry ◽  
Self Assembly ◽  
Halogen Bond ◽  
Halogen Bonding ◽  
Easy Access ◽  
Enantiomerically Pure ◽  
Wide Variability ◽  
Supramolecular Aggregation

The number of applications that use halogen bonding in the fields of self-assembly, supramolecular aggregation, and catalysis is growing. However, the accessibility of chiral halotriazoles shows that there is still a lot more to explore. The simple click-chemistry is applied for the straightforward synthesis of enantiomerically pure mono- and bidentate as well as multifunctional iodotriazole-based XB donors. The methodology is characterized by a wide variability due to easy access of chiral azides.

scholarly journals Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies

ChemMedChem ◽  
2019 ◽  
Vol 14 (21) ◽  
pp. 1863-1872 ◽  
Author(s):  
Arun K. Ghosh ◽  
Zilei Xia ◽  
Satish Kovela ◽  
William L. Robinson ◽  
Megan E. Johnson ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Enzyme Inhibition ◽  
Boronic Acids ◽  
Structural Studies ◽  
X Ray ◽  
Hiv 1

Click–click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures

2012 ◽  
Vol 48 (48) ◽  
pp. 5992 ◽  
Author(s):  
Romaric Bonnet ◽  
Pierre Murat ◽  
Nicolas Spinelli ◽  
Eric Defrancq
Keyword(s):  
Click Chemistry ◽  
Easy Access ◽  
Dna Structures
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