Click–click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures

2012 ◽  
Vol 48 (48) ◽  
pp. 5992 ◽  
Author(s):  
Romaric Bonnet ◽  
Pierre Murat ◽  
Nicolas Spinelli ◽  
Eric Defrancq
Keyword(s):  
Click Chemistry ◽  
Easy Access ◽  
Dna Structures

Synthesis of Chiral Triazole-Based Halogen Bond Donors

Synthesis ◽  
2019 ◽  
Vol 51 (10) ◽  
pp. 2128-2135 ◽  
Author(s):  
Mikk Kaasik ◽  
Sandra Kaabel ◽  
Kadri Kriis ◽  
Ivar Järving ◽  
Tõnis Kanger
Keyword(s):  
Click Chemistry ◽  
Self Assembly ◽  
Halogen Bond ◽  
Halogen Bonding ◽  
Easy Access ◽  
Enantiomerically Pure ◽  
Wide Variability ◽  
Supramolecular Aggregation

The number of applications that use halogen bonding in the fields of self-assembly, supramolecular aggregation, and catalysis is growing. However, the accessibility of chiral halotriazoles shows that there is still a lot more to explore. The simple click-chemistry is applied for the straightforward synthesis of enantiomerically pure mono- and bidentate as well as multifunctional iodotriazole-based XB donors. The methodology is characterized by a wide variability due to easy access of chiral azides.

Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry

ChemMedChem ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. 792-804 ◽  
Author(s):  
Lesley A. Howell ◽  
Richard A. Bowater ◽  
Maria A. O'Connell ◽  
Anthony P. Reszka ◽  
Stephen Neidle ◽  
...  
Keyword(s):  
Small Molecules ◽  
Click Chemistry ◽  
Dna Structures

Discrimination of monomer from multimer DNA disk-shaped toruses by freezeetch TEM

1984 ◽  
Vol 42 ◽  
pp. 210-211
Author(s):  
George C. Ruben ◽  
Kenneth A. Marx
Keyword(s):  
Biochemical Data ◽  
Dna Structures ◽  
Ice Surface ◽  
Double Stranded Dna ◽  
Data Support ◽  
Dna Organization ◽  
Trivalent Cations

In vitro collapse of DNA by trivalent cations like spermidine produces torus (donut) shaped DNA structures thought to have a DNA organization similar to certain double stranded DNA bacteriophage and viruses. This has prompted our studies of these structures using freeze-etch low Pt-C metal (9Å) replica TEM. With a variety of DNAs the TEM and biochemical data support a circumferential DNA winding model for hydrated DNA torus organization. Since toruses are almost invariably oriented nearly horizontal to the ice surface one of the most accessible parameters of a torus population is annulus (ring) thickness. We have tabulated this parameter for populations of both nicked, circular (Fig. 1: n=63) and linear (n=40: data not shown) ϕX-174 DNA toruses. In both cases, as can be noted in Fig. 1, there appears to be a compact grouping of toruses possessing smaller dimensions separated from a dispersed population possessing considerably larger dimensions.

Framework for Semantic Search Enabled Software Component Repository (SSESCR)

2018 ◽  
Author(s):  
Vishnu Sharma ◽  
Vijay Singh Rathore ◽  
Chandikaditya Kumawat
Keyword(s):  
Software Quality ◽  
Software Reuse ◽  
Development Time ◽  
Software Component ◽  
Semantic Search ◽  
Easy Access ◽  
Software Components ◽  
Efficient Search ◽  
Systematic Reuse ◽  
New System

Software reuse can improve software quality with the reducing cost and development time. Systematic reuse plan enhances cohesion and reduces coupling for better testability and maintainability. Software reuse approach can be adopted at the highest extent if relevant software components can be easily searched, adapted and integrated into new system. Large software industries hold their own well managed component libraries containing well tested software component with the project category based classification .Access to these repositories are very limited. Software reuse is facing so many problems and still not so popular. This is due to issues of general access, efficient search and adoption of software component. This paper propose a framework which resolves all of the above issues with providing easy access to components, efficient incremental semantics based search, repository management, versioning of components.

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