scholarly journals Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies

ChemMedChem ◽  
2019 ◽  
Vol 14 (21) ◽  
pp. 1863-1872 ◽  
Author(s):  
Arun K. Ghosh ◽  
Zilei Xia ◽  
Satish Kovela ◽  
William L. Robinson ◽  
Megan E. Johnson ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Enzyme Inhibition ◽  
Boronic Acids ◽  
Structural Studies ◽  
X Ray ◽  
Hiv 1

scholarly journals Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation

2016 ◽  
Vol 59 (14) ◽  
pp. 6826-6837 ◽  
Author(s):  
Arun K. Ghosh ◽  
Heather L. Osswald ◽  
Kristof Glauninger ◽  
Johnson Agniswamy ◽  
Yuan-Fang Wang ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Protein X ◽  
Hiv 1

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity

1992 ◽  
Vol 35 (14) ◽  
pp. 2525-2533 ◽  
Author(s):  
Thomas J. Tucker ◽  
William C. Lumma ◽  
Linda S. Payne ◽  
Jenny M. Wai ◽  
S. Jane De Solms ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Transition State ◽  
Protease Inhibitors ◽  
Enzyme Inhibition ◽  
Secondary Amine ◽  
Hiv 1

scholarly journals Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands

2015 ◽  
Vol 13 (48) ◽  
pp. 11607-11621 ◽  
Author(s):  
Arun K. Ghosh ◽  
Cuthbert D. Martyr ◽  
Luke A. Kassekert ◽  
Prasanth R. Nyalapatla ◽  
Melinda Steffey ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

A series of potent HIV-1 protease inhibitors with novel P2-ligands have been designed and synthesized.

Novel conformationally constrained HIV-1 protease inhibitors: rational design, enzyme inhibition, and X-ray structure of an enzyme-inhibtor complex

1994 ◽  
Vol 4 (18) ◽  
pp. 2199-2204 ◽  
Author(s):  
B.Moon Kim ◽  
Joseph P. Vacca ◽  
Paula M.D. Fitzgerald ◽  
Paul L. Darke ◽  
M.Katharine Holloway ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Enzyme Inhibition ◽  
Rational Design ◽  
Conformationally Constrained ◽  
X Ray ◽  
Hiv 1

scholarly journals Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

2020 ◽  
Vol 63 (9) ◽  
pp. 4867-4879
Author(s):  
Arun K. Ghosh ◽  
Satish Kovela ◽  
Heather L. Osswald ◽  
Masayuki Amano ◽  
Manabu Aoki ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Structural Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Hiv 1

scholarly journals Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

2017 ◽  
Vol 25 (19) ◽  
pp. 5114-5127 ◽  
Author(s):  
Arun K. Ghosh ◽  
Margherita Brindisi ◽  
Prasanth R. Nyalapatla ◽  
Jun Takayama ◽  
Jean-Rene Ella-Menye ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Biological Evaluation ◽  
Structural Studies ◽  
X Ray ◽  
Hiv 1
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