scholarly journals Hepatotoxicity associated with the dietary supplement OxyELITE Pro™ — Hawaii, 2013

2015 ◽  
Vol 8 (3-4) ◽  
pp. 319-327 ◽  
Author(s):  
David I. Johnston ◽  
Arthur Chang ◽  
Melissa Viray ◽  
Kevin Chatham‐Stephens ◽  
Hua He ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Oxyelite Pro

scholarly journals Hemodynamic and Hematologic Profile of Healthy Adults Ingesting Dietary Supplements Containing 1,3-Dimethylamylamine and Caffeine

2011 ◽  
Vol 5 ◽  
pp. NMI.S8568 ◽  
Author(s):  
Tyler M. Farney ◽  
Cameron G. McCarthy ◽  
Robert E. Canale ◽  
Rick J. Allman ◽  
Richard J. Bloomer
Keyword(s):  
Blood Glucose ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Fasting Blood Glucose ◽  
Daily Intake ◽  
Rate Pressure Product ◽  
Hemodynamic Effects ◽  
Lipid Panel ◽  
Oxyelite Pro ◽  
Hematologic Profile

Background 1,3-dimethylamylamine (a constituent of geranium), alone and in combination with caffeine, is widely used within dietary supplements. We have recently determined the hemodynamic effects of 1,3-dimethylamylamine and caffeine alone and in combination, using a single ingestion study. However, no study has determined the hemodynamic effects of these ingredients following chronic use. Moreover, no study has determined the effects of these ingredients on bloodborne variables related to health and safety. Therefore, the purpose of this investigation was to assess the hemodynamic and hematologic profile of two different dietary supplements containing 1,3-dimethylamylamine and caffeine (in addition to other ingredients), before and after two weeks of daily intake. Methods 7 men (24.9 ± 4.2 yrs) ingested the dietary supplement Jack3d™, while 4 men and 2 women (22.5 ± 1.8 yrs) ingested the dietary supplement OxyELITE Pro™ once per day for two weeks. On days 1 and 15, resting heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure were measured and rate pressure product (RPP) was calculated. Fasting blood samples were analyzed for complete blood counts, comprehensive metabolic panel, and lipid panel. These tests were done prior to ingestion of supplement. On days 1 and 15 following blood collection, subjects ingested the assigned supplement (2 servings) and HR, SBP, DBP, and RPP were recorded at 30, 60, 90, and 120 minutes post-ingestion. Results After 14 days of treatment, resting HR, SBP, DBP, and RPP were not increased ( P > 0.05). No significant changes were noted in any measured bloodborne variable, with the exception of an increase in fasting blood glucose with ingestion of Jack3d™ ( P = 0.02). In response to acute intake of the supplements, HR, DBP, and RPP were not increased statistically ( P > 0.05). SBP was increased with OxyELITE Pro™ ( P = 0.03), but not with Jack3d™ ( P = 0.09). Compared to pre-ingestion and in general, both supplements resulted in an increase in SBP, DBP, and RPP from 5%-15%, with a peak occurring at the 60 or 90 minute post-ingestion time. Conclusion Acute ingestion of OxyELITE Pro™, but not Jack3d™, results in an increase in SBP. Chronic intake of two servings per day of OxyELITE Pro™ or Jack3d™ over a 14 day period does not result in an elevation in resting HR, SBP, DBP, or RPP. No significant changes are noted in any measured bloodborne variable following 14 days of ingestion, with the exception of blood glucose with Jack3d™. Longer term intervention studies inclusive of larger sample sizes are needed to extend these findings.

scholarly journals A Finished Dietary Supplement Stimulates Lipolysis and Metabolic Rate in Young Men and Women

2011 ◽  
Vol 5 ◽  
pp. NMI.S8567 ◽  
Author(s):  
Cameron G. McCarthy ◽  
Tyler M. Farney ◽  
Robert E. Canale ◽  
Rick J. Alleman ◽  
Richard J. Bloomer
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Metabolic Rate ◽  
Dietary Supplement ◽  
Body Fat ◽  
Rate Pressure Product ◽  
Healthy Human ◽  
Men And Women ◽  
Fat Loss ◽  
Oxyelite Pro

Background Dietary supplements are often marketed to increase lipolysis and thermogenesis, with the proposed end result being weight loss and body fat reduction. It was the purpose of the present investigation to study the acute effects of a weight/fat loss supplement within a sample of healthy human subjects. Methods Twelve subjects (men 24.8 ± 4.3 yrs; women 22.8 ± 0.4 yrs) ingested a dietary supplement (OxyELITE Pro™) or a placebo, on two separate days in a double-blind, cross-over design. Blood samples were collected immediately before ingestion, and at 60 and 120 minutes post ingestion, and analyzed for plasma glycerol and free fatty acids (FFA). Breath samples were collected immediately before ingestion and at 30, 60, 90, and 120 minutes post ingestion, for a measure of kilocalorie expenditure using indirect calorimetry. Area under the curve (AUC) was calculated. Heart rate and blood pressure were recorded at all times and rate pressure product (RPP) was calculated. Results AUC was greater for supplement compared to placebo for glycerol (22.74 ± 1.98 μg · mL-1 · 2 hr-1 vs. 15.76 ± 1.36 μg · mL-1 · 2 hr-1; P = 0.001), FFA(1.62 ± 0.07 mmol · L-1 · 2 hr-1 vs. 0.78 ± 0.12 mmol · L-1 · 2 hr-1; P < 0.0001), and kilocalorie expenditure (149 ± 7 kcal · 2 hr-1 vs. 122 ± 8 kcal · 2 hr-1; P = 0.005). Heart rate ( P = 0.02), systolic blood pressure ( P < 0.0001), and RPP ( P = 0.002) were higher for supplement compared to placebo. Conclusion Ingestion of OxyELITE Pro™ resulted in an increase in blood markers of lipolysis, as well as metabolic rate, during a two-hour post ingestion time period. An increase in hemodynamic variables was also observed. These findings are in reference to a sample of healthy men and women who were naïve to treatment with the dietary supplement. Additional work is needed to determine if the acute changes observed here would persist with chronic use of the supplement and possibly lead to weight/body fat loss over time.

scholarly journals Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments

2018 ◽  
Vol 122 ◽  
pp. 21-32 ◽  
Author(s):  
Charles M. Skinner ◽  
Isabelle R. Miousse ◽  
Laura E. Ewing ◽  
Vijayalakshmi Sridharan ◽  
Maohua Cao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dietary Supplement ◽  
Obese Mouse ◽  
The Novel ◽  
Oxyelite Pro ◽  
New Formula

scholarly journals Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women

2011 ◽  
Vol 5 ◽  
pp. NMI.S8566 ◽  
Author(s):  
Cameron G. McCarthy ◽  
Robert E. Canale ◽  
Rick J. Alleman ◽  
Jacob P. Reed ◽  
Richard J. Bloomer
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Weight ◽  
Dietary Supplement ◽  
Primary Outcome ◽  
Skinfold Thickness ◽  
Resting Heart Rate ◽  
Post Intervention ◽  
Men And Women ◽  
Oxyelite Pro

Background We have recently noted an acute increase in circulating free fatty acids and glycerol, as well as resting metabolic rate, when men and women ingested the dietary supplement OxyELITE Pro™ in a single dose. We have also noted a reduction in appetite when subjects were treated with this supplement for 14 consecutive days. It is possible that such findings may favor body weight and fat loss over time. Therefore, the purpose of the present study was to determine the effects of this dietary supplement on weight loss and associated markers using an eight week intervention. Methods Exercise-trained subjects were randomly assigned in double blind manner to ingest either the dietary supplement (n = 16; aged 22.8 ± 0.7) or a placebo (n = 16; 22.5 ± 0.5) every day for eight weeks. Body weight, body composition, skinfold thickness, serum lipids, and appetite were measured as the primary outcome variables. As measures of supplement safety, a complete blood count and comprehensive metabolic panel were performed, and resting heart rate and blood pressure were measured (pre and post intervention). Results No interactions or main effects were noted for our primary outcome measures ( P > 0.05). However, when comparing pre and post intervention values for the supplement, significant decreases were noted in appetite, body weight, body fat percentage, and skinfold thickness ( P < 0.05), while increases were noted for total and HDL-C, as well as for resting heart rate ( P < 0.05). No changes were noted for placebo from pre to post intervention ( P > 0.05), with the exception of an increase in HDL-C ( P < 0.05). Blood pressure and bloodborne safety variables were not differently impacted by supplement or placebo ( P > 0.05), with the exception of monocytes, for which an interaction effect was noted ( P = 0.04). Conclusion These data indicate that the dietary supplement OxyELITE Pro™ may assist in weight and body fat loss in a sample of exercise-trained men and women. The supplement does not result in any adverse effects pertaining to resting blood pressure or bloodborne markers of safety; however a small increase in resting heart rate is observed.

Constituents from the botanical dietary supplement wild yam

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
SH Dong ◽  
D Nikolic ◽  
C Simmler ◽  
F Qiu ◽  
RB van Breemen ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Wild Yam

Investigation of ellagic acid sourcing as a dietary supplement by UFLC-PDA-ESI-MS/MS

2019 ◽  
Author(s):  
A Girme ◽  
G Saste ◽  
S Pawar ◽  
R Singh ◽  
L Hingorani
Keyword(s):  
Dietary Supplement ◽  
Ellagic Acid ◽  
Esi Ms
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